Pathological physiology is a preclinical subject that deals with etiology (causes) and pathogenesis (development) of body dysfunctions. It aims to understanding of mechanisms that can influence the origin and course of diseases, which is necessary for correct causal and individualized treatment. In the first term students are taught general principles of diseases and their effect on organism. A part of the study is devoted to states that accompany the specific diseases e.g. effects of inflammation, hypoxia, and internal environment disorders. Further students gain a comprehensive overview of etiology and pathogenesis of blood, cardiovascular and respiratory diseases. Practical part of the study is oriented mainly to acquiring knowledge of registration and description of ECG. During practical classes, students also obtain knowledge of the basic principles of immunological pathologies and mechanisms of pain development.
Poslední úprava: Kořínková Lenka (04.09.2025)
Cíl předmětu - angličtina
1.explain the general principles and consequences of impaired body functions
2.describe the pathophysiology of cardiac, pulmonary, and blood diseases
3.describe the basic parameters of the ECG curve, distinguish physiological from pathological findings, and diagnose the most common pathological changes
4.explain the basic principles of immunological pathologies and the mechanisms of pain development
Poslední úprava: Kořínková Lenka (04.09.2025)
Literatura - angličtina
Compulsory literature
Kuba, M., Kubová, Z. Pathophysiology - Basic overview for medical students (revised (only electronic) version)
Poslední úprava: Kořínková Lenka (03.09.2025)
Požadavky ke zkoušce - angličtina
Credit:
a) presence in practical classes/seminars
- mandatory 100% participation, tolerance of a maximum of one excused absence
- in case of more than one absence it is necessary to replace the seminar/practical class (the way of a replacement is determined by the teacher of the particular seminar/practical class, usually it is oral examination of the issue)
b)tests
description of four ECG curves when each must be evaluated with the worst grade 3 (in the range 1(excellent) – 4 (fail))
passing all the ongoing tests with the worst grade 3
- in case of non-participation, an apology before the time of the test is required and the test must be taken on an alternative date
- student is allowed to one excuse during the whole year
- non-excused absence is evaluated wit grade 4
Possibility of consultations after previous agreement with teachers of Department of Pathological Physiology.
When retaking the Pathological Physiology I course, it is necessary to complete the entire course with all its requirements.
Poslední úprava: Kořínková Lenka (03.09.2025)
Sylabus - angličtina
Lectures
Lecturers
prof. MUDr. Miroslav Kuba, DSc.
prof. MUDr. Zuzana Kubová, CSc.
MUDr. Marie Chutná
Organism and Environment, Adaptation. Etiology and Pathogenesis. Health Versus Disease. Clinical and Biological /Somatic/Death. (Kuba)
Alterations in Fluid Volume. Disorders of Osmolarity, Etiology and Pathogenesis of Oedema. Hyponatremia, Hypernatremia. (Kubová)
Stress, General Adaptation Syndrome, Psychosomatic Diseases. (Kuba)
Disorders of Calcium and Phosphorus Metabolism, Magnesium Imbalances. Osteoporosis, Osteomalacia, Renal Osteodystrophy. Pathophysiology of Cramps. (Kuba) TEST No. 1 - homeostasis disorders (No. 14 -19, Kubová).
Dyslipoproteinemia. Endothelial Dysfunction. Effects of Nitric oxide. Arteriosclerosis. (Kubová) RETAKE TEST No. 1.
Arterial Hypertension - Etiology and Pathogenesis. Arterial Hypotension. (Chutná)
Ischemic Heart Disease. Myocardial Infarction and its Complications. Acquired Valvular Heart Disease. Congenital Heart Defects. (Kuba)
Heart Failure - Etiology and Pathogenesis. Compensatory Mechanisms in Heart Diseases. (Kuba)
Blood Transfusion, Complications, Erythroblastosis Fetalis. Abnormalities of Haemostasias and Coagulation. (Kuba) TEST No. 2 - pathophysiology of the cardiovascular system. (No. 42 - 47, Kuba).
Disorders of Peripheral Circulation. Syncope. Circulatory Shock. Thrombophilic states. DIC. (Kubová) RETAKE TEST No. 2.
