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Course, academic year 2023/2024
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Pathophysiology - B83161 (General Medicine - English parallel)
Title: Pathophysiology
Guaranteed by: Institute of Pathological Physiology First Faculty of Medicine Charles University (11-00180)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 13
E-Credits: 13
Examination process: winter s.:
summer s.:
Hours per week, examination: winter s.:4/3, C [HT]
summer s.:2/3, C+Ex [HT]
Extent per academic year: 180 [hours]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Additional information:
Guarantor: prof. MUDr. Martin Vokurka, CSc.
Comes under: Compulsory for GM 3.y._23/24
Attributes: Lékařství
Teoretický předmět
Co-requisite : B83121
Pre-requisite : B83119, B83120
Interchangeability : B80385
Is pre-requisite for: B80128, B80082, B80114, B80402, B80120, B80118, B80760, B80762, B83007, B80410, B80304, B80305, B80579, B80307, B80602, B80084, B80613, B80122, B80123, B82105, B80116, B80078, B80098, B80126, B80033, B81311, B80791, B80080, B80121, B80129, B83011, B80308, B80113
Is interchangeable with: B80385
Pathophysiology is a bridge between theoretical medical subjects and clinical studies. Pathophysiology studies changes in the human body as influenced by various diseases. It collects data regarding the causes of various diseases and data regarding the functional changes occurring in various organs systems, organs, tissues and cells.
Last update: Kolářová Jana (12.02.2020)
Aim of the course

The course of the pathological physiology consists from lectures and seminars.

Students are motivated to actively participate in the teaching during seminars and some home work with the aim to prepare them for continuous studies of pathophysiology during their clinical studies and as a part of the continuous medical education.

The two semester course deals with pathophysiology of different organ systems of the body, roughly corresponding to clinical specialization, particularly in the internal medicine. General mechanism causing and underlying diseases are included into the teaching curriculum.

Last update: Kolářová Jana (12.02.2020)

Introduction. History of pathophysiology. Health and disease. Organ, cellular and molecular level of etiopathogenesis of the disease.

Haematopoiesis and its regulation, failure of haematopoiesis, leukemogenesis

Anemias I

Anemias II and polycythemias.

Myeloproliferative disease: CML, AML, myelodysplastic syndromes

Lymphoproliferative disease: lymphomas, CLL, plasmocytoma and amyloidosis

Immunohematology, pathophysiological aspects of blood transfusion, stem cell and bone marrow transplantation

DISORDER OF CIRCULATORY SYSTEM. Disorders of blood pressure, their causes and consequences

Role of physiological regulation in pathophysiology of cardiovascular disease and in general

Heart insufficiency and heart failure.

Congenital heart disease and valvular disease.

Kardiomyopathies; Atherosclerosis.

Ischemic heart disease, angina, myocardial infarction.



Disturbances of ventilation mechanics - obstruction and restriction lung disease. Lung fibrosis.

Pathogenesis of asthma and COPD.

Disorders of ventilation perfusion matching in lungs.

Hypoxia. Pathophysiological basis of oxygenotherapy.

Disorders of the acid-base chemistry, influence of respiration, lungs and altered metabolism

RENAL DISEASE. Tubular and glomerular disorders.

Acute renal failure

Chronic renal insufficiency and failure.

Nephritic and nephrotic syndrome. Tubular disorders.

Disturbances of water and mineral balance. Edemas.

DISORDERS OF THE GASTROINTESTINAL SYSTEM. Oral cavity and oesophagus, dysphagias, gastroesophageal reflux

Disorders of the gastric secretion and function, gastroesophageal reflux

Malabsorption syndromes, disorders of small and large intestines.


Introduction, organisational information, (diagnostic methods in hematology)

Diagnostic approaches in hematology - pathophysiological aspects

Examination of blood clotting - pathophysiological aspects

block seminar I (A, B or C)

Diagnostic approaches in cardiology I - haemodynamics

Diagnostic approaches in cardiology II - ECG

Diagnostic approaches in cardiology III - arrhythmias

Pathophysiological interpretion of ECG curves and case studies

Diagnostic approaches in respiratory disease

Diagnostic approaches in renal disease - pathophysiological aspects

Examination of the internal environment - water and ions

block seminar III (A, B or C)

Credit, presentation animal models in pathophysiology/ excurtion of interested students

Special seminars:

Block I - Blood disorders

Hemorrhagic diatheses and complex disorders of hemostasis

Thrombophilic disorders

Iron, sideropenic anemia, iron overload

Block II - Circulatory system disorders

Pathophysiology of circulation using simulation models

Pathophysiology of shock and circulatory failure

Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction

Block III - Respiratory system, internal environment

Pathophysiology of respiration using simulation models

Cystic fibrosis, immunology of bronchial obstruction

Disorders of the internal environment - acid-base chemistry

Last update: Kolářová Jana (12.02.2020)
Requirements to the exam

The required extent of knowledge for the final exam is determined by the textbook, the content of lectures and seminars, and the list of exam questions.

For further informations you may contact: 

Last update: Feberová Jitka, MUDr., Ph.D. (19.09.2021)
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