SubjectsSubjects(version: 877)
Course, academic year 2020/2021
Clinical Immunology - B80033 (General Medicine - English parallel)
Title: Klinická imunologie
Guaranteed by: Institute of Immunology and Microbiology First Faculty of Medicine Charles University in Prague (11-00351)
Faculty: First Faculty of Medicine
Actual: from 2020
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/25 C+Ex [hours/semester]
Capacity: unlimited
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Explanation: MUDr. Mgr. Jitka Petanová, CSc.,
Old code: 33
Guarantor: prof. RNDr. Libuše Kolářová, CSc.
Comes under: Compulsory for GM 4.y._20/21
Attributes: Lékařství
Klinický předmět
Pre-requisite : {Prerekvizity pro zápis Mikrobiologie 2 pro ALEK}, B80384, B80385
Co-requisite : B80054, B83163
P//Is pre-requisite for: B81053
Files Comments Added by
download Immunodeficiency II.pdf Immunodeficiency. second part MUDr. Dana Čechová
Annotation -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)
Lectures and seminars in one-week block oriented to the summary of basic immunological knowledge, immunopathologic reactions and application of immunopathological mechanisms into different organs and systems. Differential diagnosis of immunopathological states, their laboratory tests and treatment.
Aim of the course
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)

The application of basic immunology mechanisms and components in the clinical immunology and allergology, differential diagnostics and therapy.

Syllabus -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)

The structure, mechanisms and function of the immune system. Immunopathologic reactions, inflammation, basic immunologic diagnoses (immunodeficiency, autoimmune diseases, allergy), transplantations. Clinical microbiology in association to immune dysfunctions. Diagnostic process, laboratory tests, treatment.

Literature -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)

Chapel, H. et al.: Essentials of Clinical Immunology. Blackwell Publishing, 2006 and new editions.
Playfair, Chain: Immunology at a Glance. Blackwell Publ., 2005
Nairn, Roderick, Helbert, Matthew: Immunology for Medical Students. ELSEVIER HEALTH SCIENCES, 2007.

Teaching methods
Last update: MUDr. Mgr. Jitka Petanová, CSc. (26.10.2020)

Presence form of education in October 2020 cancelled. Lectures and seminars in terms of study schedules (schema in SIS). Similar scheme in weeks 3, 4, 5, 10.  Education in distance form: ppt presentations for individual study in SIS - with questions, webinairs in MS TEAMS with questions and discussion (obligatory). The questions have to be answered by e-mail sent to the concrete teacher. Teachers and topics: Černý - basic immunology, Čechová - immunodeficiency, Posová - autoimmunity, Adámková - clinical microbiology, Petanová - allergology. Individual consultations (or in small groups) on request (by e-mail).

Entry requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)

Credit from Basic Immunology. Prerequisities.

Registration requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (06.09.2019)


Course completion requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (26.10.2020)

Credit: activity during seminars, presence min. 90% (presence form of education). Distance education: presence during online seminars, questions based on the topic of the day - written answers have to be sent by e-mail (before 16:00, to the teacher of the concrete thema).

Examination: oral in person, 3 questions (1 question from each topic I-III). In special situation (immediate positivity of SARS-CoV-2 test, quarantine - students or examinators) remote form of examination can occur (video meeting or videocall in MS TEAMS).

Requirements to the exam -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (26.10.2020)

Examination: oral (in person), 3 questions (1 question from each topic I-III). Terms of examination: week after the block, exam. period (January, February, June). In special situation (immediate positivity of SARS-CoV-2 test, quarantine - students or examinators) remote form of examination can occur (video meeting or videocall in MS TEAMS).


Examination topics:


I.                   Basic immunology

1.                  Basic characteristic of the innate immunity

2.                  Effector cells of the innate immunity

3.                  Humoral components of the innate immunity

4.                  Phagocytosis

5.                  Natural killer cells

6.                  Dendritic cells and their importance (+ clinical use)

7.                  Cytokines - basic characteristic. Functional groups, examples

8.                  Proinflammatory cytokines (+ clinical importance and use)

9.                  Complement system

10.              Basic characteristic of the adaptive immunity

11.              Antigen presenting cells

12.              Recognition of the antigen by T cells and by B cells - the difference

13.              Activation of B lymphocytes and T lymphocytes

14.              Specific cytotoxic reaction

15.              Immunoglobulins. Functions of antibodies

16.              Monoclonal antibodies and their use (in diagnostic and therapy)


II.                Special immunology

1.                  Interaction between cells

2.                  Mucosal immunity (structure and function); oral tolerance

3.                  Inflammation (inflammatory reaction, compounds, phases)

4.                  Clinical and laboratory signs of inflammation

5.                  Hypersensitivity reactions - types, comparison with physiological reactions, clinical examples

6.                  Hypersensitivity reaction type I

7.                  Hypersensitivity reaction type II

8.                  Hypersensitivity reaction type III

9.                  Hypersensitivity reaction type IV

10.              Antireceptor antibodies

11.              Antitumor immunity, therapy

12.              Immunological tolerance (central, peripheral)

13.              Transplantation, graft rejection and its prevention.

14.              Transplantation, graft versus host reaction

15.              Defence to extracellular and intracellular pathogens - comparison

16.              Passive and active immunization, adjuvants


III.             Clinical immunology and allergology (pathogenesis, clinical signs, examples of diseases, basic diagnostic and therapeutic possibilities)

1.                  Chronic inflammation and its complications

2.                  Primary antibody immunodeficiency

3.                  Primary cellular immunodeficiency

4.                  Complement dysfunctions

5.                  Hereditary angioedema

6.                  Phagocytic dysfunctions and clinical examples

7.                  Diagnostics of primary immunodeficiency

8.                  Secondary immunodeficiency

9.                  Therapeutic use of immunoglobulins

10.              Organ specific autoimmune diseases - basic characteristic, examples

11.              Systemic autoimmune diseases - basic characteristic, examples

12.              Systemic lupus erythematosus

13.              Sjogren´s syndrome

14.              Antiphospholipid syndrome

15.              Vasculitis - basic classification, clinical symptoms

16.              Laboratory tests for diagnostic of autoimmune diseases

17.              Groups of immunosuppressive drugs

18.              Anaphylactic and anaphylactoid reaction, treatment

19.              Allergic rhinoconjunctivitis - pathogenesis, symptoms, treatment

20.              Allergy and bronchial asthma

21.              Food allergy, intolerance

22.              Drug allergy

23.              Diagnostic of allergic diseases and their therapy

24.              Immunomodulation

25.              Immunopathologic states in haematology

26.              Immunopathologic states in neurology

27.              Immunopathologic states in respiratory system

28.              Immunopathologic states in otorhinolaryngology

29.              Immunopathologic states in gastroenterology

30.              Immunopathologic states in dermatology

31.              Immunopathologic states in nephrology

32.              Immunopathologic states in reproduction

Education plan -
Schedule block
Week of the block Day From - To Education type Theme Teacher Note
3Monday08:00 - 08:30lecture+seminarIntroduction. Structure of lectures and seminars.Inst. of Hygiene and Epidemiology, Studničkova 7, Praha 2, middle entrance, 2nd floor, Praktika 2.
08:30 - 10:00lecture+seminarTerminology. Innate immunity, adaptive immunity, prezentation of antigens. 
10:30 - 12:00lecture+seminarAntiinfectious immunity, inflammation, regulation of the immune system, mucosal IS, the tolerance. Immunooncology, transplantations. 
Tuesday08:00 - 12:00lecture+seminarImmunodeficiency 
Wednesday08:00 - 12:00lecture+seminarImmunopathologic states. Autoimmunity. 
Thursday08:00 - 12:00lecture+seminarAllergy. Allergic diseases and their treatment. 
Friday08:30 - 10:00lecture+seminarClinical microbiology and immunopathological states 
10:00 - 12:00lecture+seminarImmunopathologic states, differential diagnoses, acces to a patient. Credit. 
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