The final examination on Medical Chemistry and Biochemistry consists of two parts: written and oral. At least 57% of obtainable points must be reached in the written test in order to proceed to the oral part of the final examination. This requirement shall not be applied in case of the third exam attempt. Students who pass the written test but fail in the oral part will not write the test again in the subsequent exam attempts. If a student fails to answer a partial question at the exam, it is sufficient as a cause for termination of examination and classification of the whole exam as ‘failed’.
A student can take an examination in a subject for three times as a maximum, i.e. the student is entitled to two re-examinations, and no extraordinary terms beyond that are allowed. In case of the second re-examination in a mandatory or elective subject the student is examined by a committee consisting of at least two examiners. If the internal faculty regulations (Article 19, Paragraph 2), permit repeated registration for the subject, the examination by the committee shall be applied only to the second re-examination in case of the repeatedly registered subject. By this a right of the faculty to enable examination by the committee in other cases, if implied by the internal regulations (Article 19, Paragraph 2), is not affected.
The credit requirements and further information on the examinations can be found in the announcements on the website of biochemical institute that provides the classes in the given academic year.
Last update: Pláteník Jan, MUDr., Ph.D. (12.01.2021)
Literature - Czech
H.S. Stoker: General, Organic and Biological Chemistry. Houghton Mifflin Co., Boston, (latest edition).
P.C. Champe, R.A. Harvey, and D.R. Ferrier: Lippincott?s Illustrated Reviews: Biochemistry. Lippincott Williams & Wilkins (latest edition)
R.K. Murray et al.: Harper?s Illustrated Biochemistry. McGraw-Hill, Inc., USA (latest edition)
B. Alberts et al.: Essential Cell Biology. Garland Science Publishing, New York (latest edition)
J.M. Gerg, J.L. Tymoczko, L. Stryer: Biochemistry. Freeman, New York (latest edition).
Last update: Kohútová Vladislava, Ing. (07.01.2019)
Requirements to the exam
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Exam Questions
I. Physical, inorganic and organic chemistry
1. Types of chemical bonds, weak interactions.
2. Water and its physical and chemical properties, significance in organism.
3. Dispersion systems, solubility of substances, true and colloid solutions, emulsion and suspension.
4. Diffusion, osmosis, osmotic and oncotic pressure, dialysis, examples from biochemistry.
5. Energetics of chemical reactions, Gibbs energy and entropy, application to metabolic processes.
6. Chemical equilibrium, Guldberg-Waage law. Kinetics and energetics of reversible reactions, application in enzymology.
7. Basic techniques for separation of macromolecules (electrophoresis, chromatography, salting out) and their usage in clinical practice.
8. Spectrophotometry, principle and use in clinical biochemistry.
9. Electrolytic dissociation, dissociation constant, strong and weak electrolytes, examples from biochemistry.
10. Brönsted-Lowry theory of acids and bases, equilibrium in protolytic reactions, examples from biochemistry.
11. Autoionization of water, pH and its significance in medicine.
12. Ampholytes, their properties, examples from biochemistry.
13. Buffers, calculation of buffer pH, significance in organism.
14. Oxidation and reduction, redox potential, dependence on concentration of reactants, examples from biochemistry. Coenzymes of oxidation-reduction reactions.
15. Precipitation reactions, solubility product, formation of complexes, coordination compounds, examples and significance in biochemistry and medicine.
16. Chemical properties of main biogenic elements.
17. Oxygen and its inorganic compounds, reactivity, properties.
18. Lipid peroxidation.
19. Toxicologically significant elements, mechanism of action of selected toxic compounds (CO, KCN, HCN, H2S, heavy metals).
20. Biologic and metabolic significance of trace elements.
21. Structure of organic compounds, isomerism, examples from metabolic pathways.
22. Halogen- and nitroderivatives of hydrocarbons, examples of toxicologically and medically significant compounds.
23. Sulfur derivatives of hydrocarbons, examples of medically significant compounds.
24. Amines, significance in biochemistry.
25. Alcohols, phenols, aldehydes and ketones, roles in metabolism. Substances used as disinfectants, mechanism of their action.
26. Carboxylic acids, functional and substitution derivatives of carboxylic acids, use in biochemistry.
27. Nitrogen, oxygen and sulfur heterocycles, significance.
28. Structural features of amino acids, classification, reactions, significance.
29. Peptides, peptide bond, examples of biologically important peptides.
30. Proteins, primary, secondary, tertiary and quaternary structure. Suprasecondary structures (motifs), protein domains. Protein misfolding. Properties and functions of proteins.
35. Lipids – classification, structure, properties, function in the organism.
36. Fatty acids.
37. Phospholipids and sphingolipids, structure, properties and significance.
38. Sterols, bile acids and steroid hormones, structure, function and significance in the organism.
II. Metabolism
1. Structure of enzymes (simple and conjugated; apoenzyme and holoenzyme; cofactors: coenzymes, prosthetic groups, coactivators; oligomeric structure); multiple enzyme forms and isoenzymes. Classification of enzymes. Examples, significance.
2. Enzyme activity and its measurement, physico-chemical influences, regulation (expression, covalent modifications, allosteric effects). Use of enzymology in medicine.
3. Energetics of enzyme catalysis. Kinetics of monomeric and oligomeric enzymes, examples. Km, kcat, catalytic efficiency of enzymes.
4. Inhibition of enzymes: competitive, non-competitive, covalent, allosteric. Use of enzyme inhibitors in medicine.
5. The respiratory chain. Oxidative phosphorylation. Substrate shuttles for transport of electrons across mitochondrial membranes.
8. General mechanisms of amino acid conversions, deamination, transamination, decarboxylation. Nitrogen balance.
9. Metabolism of one-carbon residues. Sources and utilization of one-carbon residues, cofactors.
10. Production of ammonia, its detoxication, ureosynthetic cycle and its regulation, hyperammonemia.
11. Metabolism of amino acids of the pyruvate and oxaloacetate groups, participation of these amino acids in metabolic processes.
12. Metabolism of carbon skeleton of amino acids of the 2-oxoglutarate group and branched-chain amino acids, participation of these amino acids in metabolic processes.
13. Catabolism of aromatic amino acids, disorders.
14. Metabolism of sulfur amino acids.
15. Biosynthesis, biodegradation and function of the most significant biogenic amines.
16. Conversion of amino acids to specialized products: creatine, S-adenosylmethionine, carnitine, taurine, their significance.
17. Glycolysis, energetic yield, utilization by various body organs at different physiological conditions, regulations, oxidation of pyruvate, pyruvate dehydrogenase complex.
18. Gluconeogenesis, significance, regulation.
19. Synthesis and degradation of glycogen, significance, regulation, disorders.
20. Pentose phosphate cycle, regulation.
21. Metabolism of galactose and fructose, disorders.
22. Metabolism of glucuronic acid and its significance in the organism.
23. Biosynthesis of fatty acids.
24. Formation of ketone bodies from acetyl-CoA, metabolic causes, significance.
25. Oxidation of fatty acids, energetic yield, carnitine system.
26. Triacylglycerols, biosynthesis, degradation.
27. Biosynthesis and degradation of phospholipids (glycerophospholipids and sphingolipids).
28. Biosynthesis of prostaglandins, thromboxanes and leukotrienes.
29. Biosynthesis of cholesterol and its regulation, role of HMG-CoA reductase and SREBP protein.
30. Conversion and excretion of cholesterol, biosynthesis of bile acids and its regulation.
31. Biosynthesis and degradation of steroid hormones.
32. Transport of lipids, roles of lipoproteins, structure of lipoprotein particles. Electrophoresis of lipoproteins.
33. Transport of endogenous and exogenous cholesterol (origin, conversion and role of chylomicrons, VLDL, LDL and HDL lipoproteins).
34. Biosynthesis of tetrapyrroles – heme, and its disorders. Incorporation of heme into apoproteins and its function.
35. Degradation of tetrapyrroles – heme, and its disorders. Intravascular and extravascular decomposition of erythrocytes.
36. Metabolism of purine nucleotides, regulation, inhibitors, disorders.
37. Metabolism of pyrimidine nucleotides, regulation, inhibitors, disorders.
38. Reactive oxygen species, origin and significance, antioxidants.
III. Biochemistry of organsand functions
1. Biochemical interrelationships between metabolism of saccharides and other nutrients.
4. Regulation of heme biosynthesis, differences between hepatocyte and erythroid cell, metabolism of iron.
5. Mechanism of action of hormones regulating water and mineral metabolism.
6. Hormonal regulation of energetic metabolism.
7. Biochemical processes in digestion of saccharides, lipids and proteins.
8. Biochemical functions of the hepatocyte and liver, possibilities of biochemical diagnostics of hepatocyte damage and liver functions.
9. Biotransformation of endogenous and exogenous substances, types of biotransformation processes, toxic and cancerogenic substances in the environment.
10. Buffering systems in the organism, function and significance for acid-base balance.
11. Metabolism of erythrocytes.
12. Important proteins of blood plasma, importance in the organism (albumin, Ig, acute phase proteins, transport proteins).
13. Blood coagulation, cascade of coagulation factors, initiation, amplification and propagation, tenase and prothrombinase complexes. Role of thrombocytes and vitamin K.
14. Fibrin, fibrinolysis. Mechanism of action of anticoagulants.
15. Urine – physiological and pathological components.
16. Extracellular matrix, extracellular polysaccharides and proteins (collagen, elastin) – structure, properties, function. Metabolism of collagen.
17. Biochemistry of connective tissue (cartilage, bone).
18. Biochemistry of the skin (barrier function, vitamin D, cytokeratins, cell junctions, biosynthesis of melanin).
19. Contractile apparatus, control of smooth muscle and striated muscle contraction.
20. Markers of muscle damage, significance, determination.
21. Biochemistry of vision, Wald cycle, transducin cycle.
22. Biochemistry of senses (taste, smell).
23. Biochemistry of nervous synapses, neurotransmitters.
25. Steroid hormones – structure of receptors for steroid hormones, mechanism of action, functions.
26. Peptidic hormones – mechanisms of action, functions.
27. Local mediators (cytokines, growth factors, chemokines) – functions, mechanism of action.
28. Hormones of the thyroid gland and their function in regulatory processes.
29. Structure and function of the individual parts of the immunoglobulin molecules. Classes of immunoglobulins, properties and function. Monoclonal antibodies – preparation and use.
30. Molecular basis of immunoglobulin diversity in the primary and secondary antibody response, somatic recombination, isotype switching.
31. Molecular foundations of cellular immunity – pathogen recognition by cells of specific and innate immunity, effector mechanisms. MHC molecules – structure, function, mechanisms of antigen presentation to Tc and TH lymphocytes.
33. Biochemical significance of fat-soluble vitamins.
34. Biochemical significance of water-soluble vitamins, cofactors derived from these vitamins.
35. Structure, composition and properties of cellular membranes.
36. Transport of substances across membranes.
37. Cytoskeleton.
38. Compartmentation of biochemical processes at the subcellular level.
IV. Cellular and molecular biology
1. Principles, mechanisms and significance of intercellular communication and intracellular signal transduction cascades.
2. Types of membrane receptors, their ligands, biological significance, examples.
3. Intracellular receptors, heat-shock proteins, interactions of receptors with DNA.
4. Amplification, integration and cross-talk of signaling pathways.
5. G-proteins – structure, activation, function.
6. Types and role of second messengers in signal transduction.
7. Mechanism and significance of reversible phosphorylation in signal transduction.
8. Signaling stimulated by growth factors (MAPK, PKB/AKT) and cytokines (JAK-STAT).
9. Signaling pathways dependent on regulated proteolysis, examples. Signaling role of HIF in response to hypoxia.
10. Signaling of NO, medical significance.
11. Structure and function of DNA.
12. Structure and function of RNA.
13. Organization of prokaryotic, eukaryotic and mitochondrial genome.
14. Techniques of DNA sequencing (Sanger, NGS, human genome sequencing).
15. Classification of human genomic DNA according to repetitiveness and according to function, pseudogenes, transposons.
16. Replication of eukaryotic DNA, replication machinery and its regulation.
17. DNA repair – BER, NER, MMR, direct repair of modified bases.
18. DNA repair – HR, NHEJ.
19. Transcription of prokaryotic and eukaryotic genomic DNA. Transcription factors, interaction DNA-protein.
20. Structure of mRNA, post-transcriptional modification (capping, poly(A), splicing).
21. RNA interference, types and functions of non-coding RNA.
22. Regulation of gene expression at the transcription level.
23. Genetic code and its properties.
24. Eukaryotic and prokaryotic translation. Regulation of translation.
25. Protein sorting and targeting. Post-translational protein modifications.
26. Biosynthesis of glycoproteins, their significance.
27. Vesicular transport. Endocytosis and exocytosis.
28. Restriction enzymes and other tools of genetic engineering, construction of recombinant molecules of DNA and proteins. DNA cloning.
29. Methods of cell fractionation, electrophoresis of nucleic acids and proteins.
30. Polymerase chain reaction, use of PCR in clinical diagnostics, RT-PCR and use of this technique.
31. Nature of gene mutations, inherited and acquired mutations, polymorphisms, mini- and microsatellite sequences and their uses.
32. DNA and RNA viruses – structure and replication.
33. Proto-oncogenes.
34. Tumor suppressor genes.
35. Cell cycle, role of cyclins and cdk (cyclin-dependent kinase) complexes.
36. Lysosomal and proteosomal degradation of cellular proteins. Ubiquitination of proteins.
37. Biochemistry of apoptosis, examples of pro- and anti-apoptotic genes/proteins. Caspases. Role of mitochondria in cell death.
38. Epigenetics, modification of histones, DNA methylation, significance.
Last update: Pláteník Jan, MUDr., Ph.D. (24.10.2024)
Syllabus
Introduction to physical, inorganic, and organic chemistry - principles of chemical processes, structures and characteristics of substances that are present in the human body under physiological and pathological conditions and general principles of their metabolism, basics of the metabolism of xenobiotics.
Overview of metabolic pathways - turnover of body fuels, interplay of their metabolic pathways during production, storage, and interconversion of energy and synthesis and degradation of structural and informational molecules.
Molecular biology principles of body functions - dynamics of information molecules, intracellular, intercellular, and systemic mechanisms of metabolic regulations, illustrative examples from the biochemistry of organ systems and molecular defects leading to human diseases.
Concepts of bioanalytical approaches - methods for the detection of biochemical and molecular biology markers in human medicine
Last update: Kolářová Jana (04.10.2019)
Education plan -
Schedule block
Week of the block
Day
From - To
Education type
Theme
Teacher
Files
Note
Hodnocení
1
Monday
14:15 - 17:15
practical classes
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Groups 2051, 2052
Thursday
14:15 - 17:15
practical classes
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2055, 2056
Tuesday
14:15 - 15:45
seminar
Transport of lipids. Lipoproteins.
RNDr. Marek Vecka, Ph.D.
Wednesday
14:15 - 17:15
practical classes
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2051, 2052
Thursday
14:15 - 17:15
practical classes
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2053, 2054
Friday
14:15 - 15:45
seminar
Transport of lipids. Lipoproteins.
RNDr. Marek Vecka, Ph.D.
12
Monday
14:15 - 17:15
practical classes
Metabolism of amino acids. Nitrogen balance.
Groups 2055, 2056
Wednesday
14:15 - 17:15
practical classes
Metabolism of amino acids. Nitrogen balance.
Groups 2051, 2052
Thursday
14:15 - 17:15
practical classes
Metabolism of amino acids. Nitrogen balance.
Groups 2053, 2054
13
Monday
14:15 - 17:15
seminar
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
14:15 - 15:45
practical classes
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Tuesday
14:15 - 17:15
seminar
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
Wednesday
14:15 - 15:45
practical classes
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Thursday
14:15 - 15:45
practical classes
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Friday
14:15 - 17:15
seminar
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
14
Monday
14:15 - 17:15
practical classes
Imunochemical methods.
Wednesday
14:15 - 17:15
practical classes
Imunochemical methods.
Thursday
14:15 - 17:15
practical classes
Imunochemical methods.
15
Monday
14:15 - 15:45
seminar
CREDIT
Group teachers
Tuesday
14:15 - 15:45
seminar
CREDIT
Group teachers
Friday
14:15 - 15:45
seminar
CREDIT
Group teachers
Schedule block
Week of the block
Day
From - To
Education type
Theme
Teacher
Files
Note
Hodnocení
1
Monday
14:15 - 15:45
seminar
REVISION TEST: Metabolism of saccharides, lipids, amino acids
Tuesday
14:15 - 15:45
seminar
REVISION TEST: Metabolism of saccharides, lipids, amino acids
14:15 - 17:15
practical classes
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Wednesday
14:15 - 17:15
practical classes
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Thursday
14:15 - 17:15
practical classes
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Friday
14:15 - 15:45
seminar
REVISION TEST: Metabolism of saccharides, lipids, amino acids
2
Monday
14:15 - 15:45
seminar
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
Tuesday
14:15 - 15:45
seminar
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
14:15 - 15:45
practical classes
Toxicology
Wednesday
14:15 - 15:45
practical classes
Toxicology
Thursday
14:15 - 15:45
practical classes
Toxicology
Friday
14:15 - 15:45
seminar
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
3
Monday
14:15 - 15:45
seminar
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
Tuesday
14:15 - 15:45
seminar
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
14:15 - 15:45
practical classes
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Wednesday
14:15 - 15:45
practical classes
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Thursday
14:15 - 15:45
practical classes
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Friday
14:15 - 15:45
seminar
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
4
Monday
14:15 - 15:45
seminar
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
Tuesday
14:15 - 15:45
seminar
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
14:15 - 15:45
practical classes
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Wednesday
14:15 - 15:45
practical classes
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Thursday
14:15 - 15:45
practical classes
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Friday
14:15 - 15:45
seminar
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
5
Monday
14:15 - 15:45
seminar
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
Tuesday
14:15 - 15:45
seminar
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
14:15 - 15:45
practical classes
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Wednesday
14:15 - 15:45
practical classes
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Thursday
14:15 - 15:45
practical classes
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Friday
14:15 - 15:45
seminar
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
6
Monday
14:15 - 15:45
seminar
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
Tuesday
14:15 - 15:45
seminar
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
14:15 - 15:45
practical classes
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Wednesday
14:15 - 15:45
practical classes
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Thursday
14:15 - 15:45
practical classes
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Friday
14:15 - 15:45
seminar
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
7
Monday
14:15 - 15:45
seminar
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
Tuesday
14:15 - 15:45
seminar
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
14:15 - 15:45
practical classes
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Wednesday
14:15 - 15:45
practical classes
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Thursday
14:15 - 15:45
practical classes
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Friday
14:15 - 15:45
seminar
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
8
Monday
14:15 - 15:45
seminar
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
Tuesday
14:15 - 15:45
seminar
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
14:15 - 15:45
practical classes
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Wednesday
14:15 - 15:45
practical classes
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Friday
14:15 - 15:45
nothing
Easter Holiday
9
Monday
14:15 - 15:45
nothing
Easter Holiday
Thursday
14:15 - 15:45
practical classes
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Friday
14:15 - 15:45
seminar
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
10
Monday
14:15 - 15:45
seminar
Metabolism of iron
Ing. Martina Čierna
Tuesday
14:15 - 15:45
seminar
Metabolism of iron
Ing. Martina Čierna
14:15 - 15:45
practical classes
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Wednesday
14:15 - 15:45
practical classes
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Thursday
14:15 - 15:45
practical classes
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Holiday
Friday
14:15 - 15:45
seminar
Metabolism of iron
Ing. Martina Čierna
11
Monday
14:15 - 15:45
seminar
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
Tuesday
14:15 - 15:45
seminar
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
14:15 - 15:45
practical classes
Examination of urine (physical, chemical examination, urinary sediment)
Wednesday
14:15 - 15:45
practical classes
Examination of urine (physical, chemical examination, urinary sediment)
Thursday
14:15 - 15:45
practical classes
Examination of urine (physical, chemical examination, urinary sediment)
Holiday
Friday
14:15 - 15:45
seminar
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
12
Monday
14:15 - 15:45
seminar
TUTORIAL 4: Liver and metabolism
Tuesday
14:15 - 15:45
seminar
TUTORIAL 4: Liver and metabolism
Rector's Day
14:15 - 15:45
practical classes
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Rector's Day
Wednesday
14:15 - 15:45
practical classes
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Thursday
14:15 - 15:45
practical classes
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Friday
14:15 - 15:45
seminar
TUTORIAL 4: Liver and metabolism
13
Monday
14:15 - 15:45
seminar
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
Tuesday
14:15 - 15:45
seminar
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
14:15 - 15:45
practical classes
Metabolism of calcium and phosphorus, osteoporosis.
Wednesday
14:15 - 15:45
practical classes
Metabolism of calcium and phosphorus, osteoporosis.
Thursday
14:15 - 15:45
practical classes
Metabolism of calcium and phosphorus, osteoporosis.
Friday
14:15 - 15:45
seminar
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
14
Monday
14:15 - 15:45
seminar
Consultations/compensations for missed lessons
Tuesday
14:15 - 15:45
practical classes
Practical Credit Examination
14:15 - 15:45
seminar
Consultations/compensations for missed lessons
Wednesday
14:15 - 15:45
practical classes
Practical Credit Examination
Thursday
14:15 - 15:45
practical classes
Practical Credit Examination
Friday
14:15 - 15:45
seminar
Consultations/compensations for missed lessons
15
Monday
14:15 - 15:45
seminar
Credit
Tuesday
14:15 - 15:45
seminar
Credit
Friday
14:15 - 15:45
seminar
Credit
Schedule semestral
Educational week
Date
From - To
Education type
Theme
Teacher
Files
Note
Hodnocení
1
30.09.2024
12:30 - 14:00
lecture
Introduction to study of medical biochemistry. Basic terms. Dispersion systems.
Structure, digestion, absorption and transport of saccharides.
doc. MUDr. Lucie Muchová, Ph.D.
8
18.11.2024
12:30 - 14:00
lecture
Metabolism of saccharides I.
doc. MUDr. Lucie Muchová, Ph.D.
21.11.2024
12:30 - 14:00
lecture
Metabolism of saccharides II.
doc. MUDr. Lucie Muchová, Ph.D.
9
25.11.2024
12:30 - 14:00
lecture
Structure, digestion, and absorption of lipids.
RNDr. Marek Vecka, Ph.D.
28.11.2024
12:30 - 14:00
lecture
Metabolism of fatty acids and triacylglycerols.
doc. MUDr. Evžen Křepela, CSc.
10
02.12.2024
12:30 - 14:00
lecture
Lipid mediators. Metabolism of glycerolipids and sfingolipids.
RNDr. Marek Vecka, Ph.D.
05.12.2024
12:30 - 14:00
lecture
Steroids
RNDr. Marek Vecka, Ph.D.
11
09.12.2024
12:30 - 14:00
lecture
Metabolism of amino acids, the urea cycle.
doc. MUDr. Jiří Vachtenheim, CSc.
12.12.2024
12:30 - 14:00
lecture
Catabolism of amino acids and their carbon skeletons.
doc. MUDr. Jiří Vachtenheim, CSc.
12
16.12.2024
12:30 - 14:00
lecture
Conversion of amino acids to biologically active derivatives.
MUDr. Jan Krtil
13
09.01.2025
12:30 - 14:00
lecture
Metabolism of porphyrins.
doc. MUDr. Evžen Křepela, CSc.
14
09.01.2025
12:30 - 14:00
lecture
Metabolism of purines and pyrimidines
doc. MUDr. Evžen Křepela, CSc.
15
17.01.2025
12:30 - 14:00
lecture
Consultations
Schedule semestral
Educational week
Date
From - To
Education type
Theme
Teacher
Files
Note
Hodnocení
1
26.02.2025
10:45 - 12:15
lecture
Introductory lecture to the molecular biology block.
prof. MUDr. Zdeněk Kleibl, Ph.D.
27.02.2025
12:30 - 14:00
lecture
Nucleic acids: Structure, properties and significance. Levels in DNA & RNA structure. Organization of nuclear DNA, histones. Principles of DNA-protein interaction.
doc. MUDr. Jiří Vachtenheim, CSc.
2
05.03.2025
10:45 - 12:15
lecture
DNA replication. Pro- and eukaryotic DNA polymerases. Types and classifications of DNA alterations.
Mgr. Jan Ševčík, Ph.D.
06.03.2025
12:30 - 14:00
lecture
DNA repair. DNA reparation pathways. Direct repair, BER, NER, MMR, repair of DNA strand breaks.
Mgr. Jan Ševčík, Ph.D.
3
12.03.2025
10:45 - 12:15
lecture
Biosynthesis of RNA (DNA transcription) in prokaryotic and eukaryotic cells. Posttranscriptional RNA processing. Splicing and export of RNA from the cell nucleus. Participation of histone modification in transcriptional regulation.
doc. MUDr. Jiří Vachtenheim, CSc.
13.03.2025
12:30 - 14:00
lecture
Regulation of gene expression in pro- and eukaryotic cells at the level of transcription.
prof. MUDr. Zdeněk Kleibl, Ph.D.
4
19.03.2025
10:45 - 12:15
lecture
Synthesis of proteins (translation) and its regulation.
RNDr. Jana Soukupová, Ph.D.
20.03.2025
12:30 - 14:00
lecture
Post-translational protein modifications. Cellular protein targetting.
doc. MUDr. Evžen Křepela, CSc.
5
26.03.2025
10:45 - 12:15
lecture
Intracellular protein degradation: role of lysosomes and proteasomes.
doc. MUDr. Evžen Křepela, CSc.
27.03.2025
12:30 - 14:00
lecture
Structure and function of biomembranes, cellular junctions.
RNDr. Marek Vecka, Ph.D.
6
02.04.2025
10:45 - 12:15
lecture
Mechanisms of cellular signaling and hormone actions I
MUDr. Jan Pláteník, Ph.D.
03.04.2025
12:30 - 14:00
lecture
Mechanisms of cellular signaling and hormone actions II
MUDr. Jan Pláteník, Ph.D.
7
09.04.2025
10:45 - 12:15
lecture
The cell cycle. Molecular basis of tumor growth.
doc. MUDr. Jiří Vachtenheim, CSc.
10.04.2025
12:30 - 14:00
lecture
Programs of cellular senescence and cellular death.
MUDr. Jan Pláteník, Ph.D.
8
16.04.2025
10:45 - 12:15
lecture
Lecture cancelled
17.04.2025
12:30 - 14:00
lecture
Dean's Day
9
23.04.2025
10:45 - 12:15
lecture
Introduction to organ biochemistry. Metabolism of liver, starvation, obesity.
MUDr. Jan Krtil
24.04.2025
12:30 - 14:00
lecture
Vitamins, nutrition and nutritional supplements.
RNDr. Aleš Dvořák, Ph.D.
10
30.04.2025
10:45 - 12:15
lecture
Blood clotting. Specific features of red blood cell metabolism.
MUDr. Jan Krtil
01.05.2025
12:30 - 14:00
lecture
National Holiday
11
07.05.2025
10:45 - 12:15
lecture
Metabolism of the kidney.
MUDr. Jan Krtil
08.05.2025
12:30 - 14:00
lecture
National Holiday
12
14.05.2025
10:45 - 12:15
lecture
Xenobiochemistry
RNDr. Marek Vecka, Ph.D.
15.05.2025
12:30 - 14:00
lecture
Biochemistry of muscle contraction. Extracellular matrix (proteoglycans, collagen, elastin).
doc. MUDr. Evžen Křepela, CSc.
13
21.05.2025
10:45 - 12:15
lecture
Cellular and humoral immunity. Structure of antibodies, interaction with antigen, origin of heterogenity.
Mgr. Libuše Nosková, Ph.D.
22.05.2025
12:30 - 14:00
lecture
Biochemistry of neurotransmission and sensory organs I.
MUDr. Jan Pláteník, Ph.D.
14
28.05.2025
10:45 - 12:15
lecture
Biochemistry of neurotransmission and sensory organs II.
MUDr. Jan Pláteník, Ph.D.
29.05.2025
12:30 - 14:00
lecture
Reactive oxygen and nitrogen species
prof. MUDr. Tomáš Zima, DrSc., MBA
Rozpis blokový
Týden bloku
Den
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
Pondělí
14:15 - 17:15
praktická cvičení
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Groups 2051, 2052
Čtvrtek
14:15 - 17:15
praktická cvičení
Introduction to work in chemical laboratory. Safety rules. Measuring volumes, centrifugation, filtration, dissolution, separation of substances form mixtures.
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2055, 2056
Úterý
14:15 - 15:45
seminář
Transport of lipids. Lipoproteins.
RNDr. Marek Vecka, Ph.D.
Středa
14:15 - 17:15
praktická cvičení
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2051, 2052
Čtvrtek
14:15 - 17:15
praktická cvičení
Reactions of lipids. Digestion of lipids. Biochemical examination of lipid metabolism.
Groups 2053, 2054
Pátek
14:15 - 15:45
seminář
Transport of lipids. Lipoproteins.
RNDr. Marek Vecka, Ph.D.
12
Pondělí
14:15 - 17:15
praktická cvičení
Metabolism of amino acids. Nitrogen balance.
Groups 2055, 2056
Středa
14:15 - 17:15
praktická cvičení
Metabolism of amino acids. Nitrogen balance.
Groups 2051, 2052
Čtvrtek
14:15 - 17:15
praktická cvičení
Metabolism of amino acids. Nitrogen balance.
Groups 2053, 2054
13
Pondělí
14:15 - 17:15
seminář
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
14:15 - 15:45
praktická cvičení
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Úterý
14:15 - 17:15
seminář
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
Středa
14:15 - 15:45
praktická cvičení
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Čtvrtek
14:15 - 15:45
praktická cvičení
TUTORIAL 3: Amino acids, lipids, conections among metabolic pathways
Pátek
14:15 - 17:15
seminář
Selected immunochemical methods.
Mgr. Libuše Nosková, Ph.D.
14
Pondělí
14:15 - 17:15
praktická cvičení
Imunochemical methods.
Středa
14:15 - 17:15
praktická cvičení
Imunochemical methods.
Čtvrtek
14:15 - 17:15
praktická cvičení
Imunochemical methods.
15
Pondělí
14:15 - 15:45
seminář
CREDIT
Group teachers
Úterý
14:15 - 15:45
seminář
CREDIT
Group teachers
Pátek
14:15 - 15:45
seminář
CREDIT
Group teachers
Rozpis blokový
Týden bloku
Den
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
Pondělí
14:15 - 15:45
seminář
REVISION TEST: Metabolism of saccharides, lipids, amino acids
Úterý
14:15 - 15:45
seminář
REVISION TEST: Metabolism of saccharides, lipids, amino acids
14:15 - 17:15
praktická cvičení
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Středa
14:15 - 17:15
praktická cvičení
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Čtvrtek
14:15 - 17:15
praktická cvičení
Introduction to pre-analytics of laboratory examination (Practice of venipuncture on a model of arm)
Pátek
14:15 - 15:45
seminář
REVISION TEST: Metabolism of saccharides, lipids, amino acids
2
Pondělí
14:15 - 15:45
seminář
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
Úterý
14:15 - 15:45
seminář
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
14:15 - 15:45
praktická cvičení
Toxicology
Středa
14:15 - 15:45
praktická cvičení
Toxicology
Čtvrtek
14:15 - 15:45
praktická cvičení
Toxicology
Pátek
14:15 - 15:45
seminář
Introduction to the block of molecular biology
prof. MUDr. Zdeněk Kleibl, Ph.D.
3
Pondělí
14:15 - 15:45
seminář
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
Úterý
14:15 - 15:45
seminář
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
14:15 - 15:45
praktická cvičení
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Středa
14:15 - 15:45
praktická cvičení
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Čtvrtek
14:15 - 15:45
praktická cvičení
Isolation of DNA from buccal smear. Measurement of concentration of isolated DNA. / Cell fractionation, isolation and purification of genetic material. Characterization and quantification of DNA. Properties of DNA/RNA.
Pátek
14:15 - 15:45
seminář
Structure of nucleic acids
MUDr. Martin Leníček, Ph.D.
4
Pondělí
14:15 - 15:45
seminář
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
Úterý
14:15 - 15:45
seminář
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
14:15 - 15:45
praktická cvičení
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Středa
14:15 - 15:45
praktická cvičení
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Čtvrtek
14:15 - 15:45
praktická cvičení
Electroforesis of isolated DNA. Amplification of fragments including intron 10, exon 13 and exon 14 of DPYD gene by means of PCR. / PCR and its modification (RT-PCR, qPCR).
Pátek
14:15 - 15:45
seminář
Selected methods of molecular biology
RNDr. Markéta Šafaříková, Ph.D.
5
Pondělí
14:15 - 15:45
seminář
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
Úterý
14:15 - 15:45
seminář
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
14:15 - 15:45
praktická cvičení
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Středa
14:15 - 15:45
praktická cvičení
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Čtvrtek
14:15 - 15:45
praktická cvičení
Electroforesis of all PCR products. Restriction analysis of PCR products with intron 10 and exon 14 of DPYD gene. / Restriction enzymes and their usage (restriction analysis, DNA cloning).
Pátek
14:15 - 15:45
seminář
Next Generation Sequencing (NGS)
RNDr. Markéta Šafaříková, Ph.D.
6
Pondělí
14:15 - 15:45
seminář
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
Úterý
14:15 - 15:45
seminář
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
14:15 - 15:45
praktická cvičení
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Středa
14:15 - 15:45
praktická cvičení
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Čtvrtek
14:15 - 15:45
praktická cvičení
Electroforesis of restriction analysis. Preparation of sequencing reaction for DPYD exon 13. /Sanger's sequencing and evaluation of sequencing chromatograms.
Pátek
14:15 - 15:45
seminář
Regulation of expression of genetic information at various levels, RNA interference, microRNA.
Ing. Kateřina Žížalová, Ph.D.
7
Pondělí
14:15 - 15:45
seminář
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
Úterý
14:15 - 15:45
seminář
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
14:15 - 15:45
praktická cvičení
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Středa
14:15 - 15:45
praktická cvičení
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Čtvrtek
14:15 - 15:45
praktická cvičení
Precipitation of sequencing reaction and preparation of Sanger's sequencing./ Significance of analysis DNA, RNA and proteins in diagnostics.
Pátek
14:15 - 15:45
seminář
Advanced analytical methods (GC, HPLC, MS, MALDI)
RNDr. Marek Vecka, Ph.D.
8
Pondělí
14:15 - 15:45
seminář
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
Úterý
14:15 - 15:45
seminář
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
14:15 - 15:45
praktická cvičení
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Středa
14:15 - 15:45
praktická cvičení
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Pátek
14:15 - 15:45
nic
Easter Holiday
9
Pondělí
14:15 - 15:45
nic
Easter Holiday
Čtvrtek
14:15 - 15:45
praktická cvičení
Evaluation of sequencing chromatograms and restriction analyses, relationship of found phenotypes to 5FU toxicity. REVISION TEST molecular biology
Pátek
14:15 - 15:45
seminář
Regulations of energetic metabolism
MUDr. Jan Pláteník, Ph.D.
10
Pondělí
14:15 - 15:45
seminář
Metabolism of iron
Ing. Martina Čierna
Úterý
14:15 - 15:45
seminář
Metabolism of iron
Ing. Martina Čierna
14:15 - 15:45
praktická cvičení
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Středa
14:15 - 15:45
praktická cvičení
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Čtvrtek
14:15 - 15:45
praktická cvičení
Liver, tetrapyrrols: GGT, total and direct bilirubin. Blood clotting. Cardiomarkers.
Holiday
Pátek
14:15 - 15:45
seminář
Metabolism of iron
Ing. Martina Čierna
11
Pondělí
14:15 - 15:45
seminář
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
Úterý
14:15 - 15:45
seminář
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
14:15 - 15:45
praktická cvičení
Examination of urine (physical, chemical examination, urinary sediment)
Středa
14:15 - 15:45
praktická cvičení
Examination of urine (physical, chemical examination, urinary sediment)
Čtvrtek
14:15 - 15:45
praktická cvičení
Examination of urine (physical, chemical examination, urinary sediment)
Holiday
Pátek
14:15 - 15:45
seminář
Diabetes mellitus and metabolic syndrome
MUDr. Miloš Mráz, Ph.D.
12
Pondělí
14:15 - 15:45
seminář
TUTORIAL 4: Liver and metabolism
Úterý
14:15 - 15:45
seminář
TUTORIAL 4: Liver and metabolism
Rector's Day
14:15 - 15:45
praktická cvičení
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Rector's Day
Středa
14:15 - 15:45
praktická cvičení
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Čtvrtek
14:15 - 15:45
praktická cvičení
Examination of renal function: Creatinin, uric acid. Sodium ions. Proteinuria: total proteinuria, evaluation of ELFO. Protein in cerebrospinal fluid.
Pátek
14:15 - 15:45
seminář
TUTORIAL 4: Liver and metabolism
13
Pondělí
14:15 - 15:45
seminář
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
Úterý
14:15 - 15:45
seminář
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
14:15 - 15:45
praktická cvičení
Metabolism of calcium and phosphorus, osteoporosis.
Středa
14:15 - 15:45
praktická cvičení
Metabolism of calcium and phosphorus, osteoporosis.
Čtvrtek
14:15 - 15:45
praktická cvičení
Metabolism of calcium and phosphorus, osteoporosis.
Pátek
14:15 - 15:45
seminář
Disorders of acid-base balance
doc. MUDr. Helena Lahoda Brodská, Ph.D.
14
Pondělí
14:15 - 15:45
seminář
Consultations/compensations for missed lessons
Úterý
14:15 - 15:45
praktická cvičení
Practical Credit Examination
14:15 - 15:45
seminář
Consultations/compensations for missed lessons
Středa
14:15 - 15:45
praktická cvičení
Practical Credit Examination
Čtvrtek
14:15 - 15:45
praktická cvičení
Practical Credit Examination
Pátek
14:15 - 15:45
seminář
Consultations/compensations for missed lessons
15
Pondělí
14:15 - 15:45
seminář
Credit
Úterý
14:15 - 15:45
seminář
Credit
Pátek
14:15 - 15:45
seminář
Credit
Rozpis semestrální
Výukový týden
Datum
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
30.09.2024
12:30 - 14:00
přednáška
Introduction to study of medical biochemistry. Basic terms. Dispersion systems.
Structure, digestion, absorption and transport of saccharides.
doc. MUDr. Lucie Muchová, Ph.D.
8
18.11.2024
12:30 - 14:00
přednáška
Metabolism of saccharides I.
doc. MUDr. Lucie Muchová, Ph.D.
21.11.2024
12:30 - 14:00
přednáška
Metabolism of saccharides II.
doc. MUDr. Lucie Muchová, Ph.D.
9
25.11.2024
12:30 - 14:00
přednáška
Structure, digestion, and absorption of lipids.
RNDr. Marek Vecka, Ph.D.
28.11.2024
12:30 - 14:00
přednáška
Metabolism of fatty acids and triacylglycerols.
doc. MUDr. Evžen Křepela, CSc.
10
02.12.2024
12:30 - 14:00
přednáška
Lipid mediators. Metabolism of glycerolipids and sfingolipids.
RNDr. Marek Vecka, Ph.D.
05.12.2024
12:30 - 14:00
přednáška
Steroids
RNDr. Marek Vecka, Ph.D.
11
09.12.2024
12:30 - 14:00
přednáška
Metabolism of amino acids, the urea cycle.
doc. MUDr. Jiří Vachtenheim, CSc.
12.12.2024
12:30 - 14:00
přednáška
Catabolism of amino acids and their carbon skeletons.
doc. MUDr. Jiří Vachtenheim, CSc.
12
16.12.2024
12:30 - 14:00
přednáška
Conversion of amino acids to biologically active derivatives.
MUDr. Jan Krtil
13
09.01.2025
12:30 - 14:00
přednáška
Metabolism of porphyrins.
doc. MUDr. Evžen Křepela, CSc.
14
09.01.2025
12:30 - 14:00
přednáška
Metabolism of purines and pyrimidines
doc. MUDr. Evžen Křepela, CSc.
15
17.01.2025
12:30 - 14:00
přednáška
Consultations
Rozpis semestrální
Výukový týden
Datum
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
26.02.2025
10:45 - 12:15
přednáška
Introductory lecture to the molecular biology block.
prof. MUDr. Zdeněk Kleibl, Ph.D.
27.02.2025
12:30 - 14:00
přednáška
Nucleic acids: Structure, properties and significance. Levels in DNA & RNA structure. Organization of nuclear DNA, histones. Principles of DNA-protein interaction.
doc. MUDr. Jiří Vachtenheim, CSc.
2
05.03.2025
10:45 - 12:15
přednáška
DNA replication. Pro- and eukaryotic DNA polymerases. Types and classifications of DNA alterations.
Mgr. Jan Ševčík, Ph.D.
06.03.2025
12:30 - 14:00
přednáška
DNA repair. DNA reparation pathways. Direct repair, BER, NER, MMR, repair of DNA strand breaks.
Mgr. Jan Ševčík, Ph.D.
3
12.03.2025
10:45 - 12:15
přednáška
Biosynthesis of RNA (DNA transcription) in prokaryotic and eukaryotic cells. Posttranscriptional RNA processing. Splicing and export of RNA from the cell nucleus. Participation of histone modification in transcriptional regulation.
doc. MUDr. Jiří Vachtenheim, CSc.
13.03.2025
12:30 - 14:00
přednáška
Regulation of gene expression in pro- and eukaryotic cells at the level of transcription.
prof. MUDr. Zdeněk Kleibl, Ph.D.
4
19.03.2025
10:45 - 12:15
přednáška
Synthesis of proteins (translation) and its regulation.
RNDr. Jana Soukupová, Ph.D.
20.03.2025
12:30 - 14:00
přednáška
Post-translational protein modifications. Cellular protein targetting.
doc. MUDr. Evžen Křepela, CSc.
5
26.03.2025
10:45 - 12:15
přednáška
Intracellular protein degradation: role of lysosomes and proteasomes.
doc. MUDr. Evžen Křepela, CSc.
27.03.2025
12:30 - 14:00
přednáška
Structure and function of biomembranes, cellular junctions.
RNDr. Marek Vecka, Ph.D.
6
02.04.2025
10:45 - 12:15
přednáška
Mechanisms of cellular signaling and hormone actions I
MUDr. Jan Pláteník, Ph.D.
03.04.2025
12:30 - 14:00
přednáška
Mechanisms of cellular signaling and hormone actions II
MUDr. Jan Pláteník, Ph.D.
7
09.04.2025
10:45 - 12:15
přednáška
The cell cycle. Molecular basis of tumor growth.
doc. MUDr. Jiří Vachtenheim, CSc.
10.04.2025
12:30 - 14:00
přednáška
Programs of cellular senescence and cellular death.
MUDr. Jan Pláteník, Ph.D.
8
16.04.2025
10:45 - 12:15
přednáška
Lecture cancelled
17.04.2025
12:30 - 14:00
přednáška
Dean's Day
9
23.04.2025
10:45 - 12:15
přednáška
Introduction to organ biochemistry. Metabolism of liver, starvation, obesity.
MUDr. Jan Krtil
24.04.2025
12:30 - 14:00
přednáška
Vitamins, nutrition and nutritional supplements.
RNDr. Aleš Dvořák, Ph.D.
10
30.04.2025
10:45 - 12:15
přednáška
Blood clotting. Specific features of red blood cell metabolism.
MUDr. Jan Krtil
01.05.2025
12:30 - 14:00
přednáška
National Holiday
11
07.05.2025
10:45 - 12:15
přednáška
Metabolism of the kidney.
MUDr. Jan Krtil
08.05.2025
12:30 - 14:00
přednáška
National Holiday
12
14.05.2025
10:45 - 12:15
přednáška
Xenobiochemistry
RNDr. Marek Vecka, Ph.D.
15.05.2025
12:30 - 14:00
přednáška
Biochemistry of muscle contraction. Extracellular matrix (proteoglycans, collagen, elastin).
doc. MUDr. Evžen Křepela, CSc.
13
21.05.2025
10:45 - 12:15
přednáška
Cellular and humoral immunity. Structure of antibodies, interaction with antigen, origin of heterogenity.
Mgr. Libuše Nosková, Ph.D.
22.05.2025
12:30 - 14:00
přednáška
Biochemistry of neurotransmission and sensory organs I.
MUDr. Jan Pláteník, Ph.D.
14
28.05.2025
10:45 - 12:15
přednáška
Biochemistry of neurotransmission and sensory organs II.
