SubjectsSubjects(version: 983)
Course, academic year 2025/2026
   
Occupational Medicine and Toxicology - B80113 (General Medicine AP)
Title: Occupational Medicine and Toxicology
Guaranteed by: Department of Occupational Medicine First Faculty of Medicine Charles University and General University Hospital in Prague (11-00560)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/25, C+Ex [HS]
Extent per academic year: 25 [hours]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Explanation: Assoc. Prof. Sergej Zacharov, MD, PhD.White uniforms, stethoscopes
Additional information: http://nempov.lf1.cuni.cz/
Old code: 113
Guarantor: prof. MUDr. Sergej Zacharov, Ph.D.
Attributes: Lékařství
Klinický předmět
Pre-requisite : B80632, B83161, B83162
Annotation -
Legal aspects of occupational medicine, prevention of occupational diseases, occupational pneumology, occupational neurology, occupational carcinogens, occupational diseases due to vibrations and overload of extremities. Clinical and occupational toxicology and damage caused by ionizing radiation. Occupational health services.
Last update: PEL03831 (12.06.2008)
Aim of the course -

In order to prevent and recognize occupational diseases, medical students learn the potentially causal relationships between job and disease in an interesting, patient oriented way. The also learn the basics of occupational and clinical toxicology.

Last update: PEL03831 (12.06.2008)
Literature -

LaDou J.: Occupational Medicine, 5th Edition, Appleton & Lange 2014.
Olson K.R.: Poisoning and drug overdose. 7th Edition, McGraw-Hill Comp., Inc. 2018.

Last update: Pelclová Daniela, prof. MUDr., CSc. (09.11.2025)
Teaching methods -

Seminars, examination of patients, presentation of laboratory methods, reading of radiological findings, discussion groups, test.

Last update: PEL03831 (16.05.2019)
Requirements to the exam -

The date of examination cannot be earlier than the last date of the course. Attendance at all days of the course and successful final test are the mandatory preconditions for examination which will be checked before the examination.

In case of the planned/unplanned absence at certain hours during the course due to objective reasons (disease etc.) please contact the Head of the department by email sergej.zacharov@lf1.cuni.cz to consult the further steps.  

 

Occupational Medicine and Toxicology, Questions

1.

Occupational allergic rhinitis.

Intoxication with cyanides.

2.

Extrinsic allergic alveolitis (chronic form).

Antidotes for intoxications.

3.

Coal worker's pneumoconiosis.

Intoxication with paracetamol, benzodiazepines, morphine, antidepressants (tricyclic, SSRI).

4.

Diseases due to asbestos (non-malignant and malignant).

Intoxication with ethanol, ethylene glycol and methyl alcohol.

5.

Deterministic effects of ionizing radiation (acute radiation syndrome, dermatitis, cataract, sterility).

Acids and alkalis, first aid after ingestion and contamination of the skin and the eyes.

6.

Intoxication with pesticides (organophosphates, carbamates, rodenticides).

Occupational diseases. Definition, list of occupational diseases, legislation, compensation, socio-legal aspects.

7.

Intoxication with organic solvents (general symptoms, toluene, trichloroethylene, perchloroethylene, gasoline).

Occupational preventive care. Preventive examinations of workers performing hazardous jobs.

8.

Intoxications with organic solvents (general symptoms, benzene, carbon tetrachloride, chloroform).

Diseases due to physical overload of extremities.

9.

Intoxication with carbon monoxide.

Hallucinogens: psychedelics (classical hallucinogens), deliriants, dissociatives. Mechanism, psychological and physiological effects, toxicity, treatment

10.

Endangerment by occupational disease, legislation, socio-legal aspects. Biological exposure tests.

Intoxication with mushrooms (A. phalloides, A. pantherina, Psilocybe, Cortinarius).

11.

Occupational peripheral neuropathy (toxic - carbon disulfide, methylalcohol; due to overload, due to vibrations).

Recreational drugs. Sympatomimetic toxidrome. Serotonin syndrome.

12.

Diseases due to vibrations.

Intoxication with mercury, health risks, prevention.

13.

Intoxication with lead, health risks, prevention.

Occupational skin diseases (allergic and non-allergic), diagnostics and management.

14.

Acute damage of the airways and lungs due to irritants (chlorine, nitrogen oxides, gasoline, metals).

Intoxication with methemoglobinizing chemicals.

15.

Extrinsic allergic alveolitis (acute form).

Occupational cancer (chemical, physical, IARC classification).

16.

Occupational asthma.

Noise-induced hearing loss.

17.

First aid in acute intoxications, indication and contra-indications of charcoal. Material Safety Data sheets. Toxicological information Centre.

Benign pneumoconiosis - welder´s lung. Metal fume fever.

18.

Silicosis.

Contamination with radionuclides. Diagnostics, external decontamination of patients, personal protective equipment, treatment.

Last update: PEL03831 (13.11.2019)
Syllabus

Occupational diseases, Czech List of Occupational Diseases, European Schedule of Occupational Diseases, legislation.

Most frequent occupational diseases in Czech Republic, duties of physicians concerning suspection of the occupational origin of a disease, notification, social and economic impact. Endangerment by an occupational disease.

Occupational preventive care. Monitoring of the exposure to noxae in the occupational environment, biological exposure tests, preventive examinations of workers.

First aid in acute intoxications.

Intoxications with illegal drugs.

Antidotes for intoxications.

Intoxications:

* hydrogen cyanide and cyanides

* organic solvents (benzene, toluene, trichlorethylene, perchloroethylene, carbon tetrachloride, chloroform, ethylalcohol, methanol,

gasoline, etyleneglycol)

* pharmaceuticals (benzodiazepins and morphine, tricyclic antidepressants, paracetamol)

* metals (lead and its compounds, mercury and its compounds)

* pesticides (organophosphates, carbamates, rodenticides)

* carbon monoxide

* methemoglobinizing compounds

* mushrooms

* damage by acids and alkalis

Occupational respiratory diseases:

* occupational allergic diseases (allergic rhinitis, asthma, allergic skin diseases)

* occupational interstitial fibroses (asbestosis, extrinsic allergic alveolitis)

* silicosis and coal worker´s pneumoconiosis

* COPD due to black coal

* diseases due to asbestos (benign diseases and tumours)

* acute damage of the airways and lungs due to irritant gases, vapours and dusts

Occupational damage of the peripheral nerves (toxic, due to overload, vibrations-induced)

Disease due to vibrations

Diseases due to overload of upper extremities

Occupational carcinogens (chemical and physical), classification of carcinogens by IARC. Most common occupational carcinogens and their target organs.

Deterministic (non-stochastic) effects of ionizing radiation.

Last update: PEL03831 (16.05.2019)
Entry requirements -

Pathology, pathophysiology, internal propedeutics.

Last update: PEL03831 (16.05.2019)
 
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