Medical Immunology - FDP047

• Anglický název: Medical Immunology
• Zajišťuje: Ústav klinické imunologie a alergologie (15-630)
• Fakulta: Lékařská fakulta v Hradci Králové
• Platnost: od 2021 do 2024
• Semestr: zimní
• Body: 0
• E-Kredity: 2
• Způsob provedení zkoušky: zimní s.:
• Rozsah, examinace: zimní s.:21/9, Z [HS]
• Počet míst: neomezen
• Minimální obsazenost: neomezen
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: vyučován
• Jazyk výuky: angličtina
• Způsob výuky: prezenční
• Garant: prof. RNDr. Jan Krejsek, CSc.
• Prerekvizity : {Povinné předměty AZUBNI 2. ročník (2019->)}
• Neslučitelnost : FZ10046
• Záměnnost : FA0207100, FZ10046
• Je korekvizitou pro: FDP063
• Ve slož. prerekvizitě: FDP077, FDP078
• Ve slož. korekvizitě pro: FDP078

Anotace

Fundamental of Medical Immunology is realized in the forms of lectures, seminars and practicals. The aim is to introduce the complex and modern concept of the function of the immune system as principal integrating body system. The emphasize is put on the understanding of the role of cellular substrate of immune response, differentiation of immune cells and description of their function. Special emphasize is given to gain the knowledge of the participation of immune system into the both protective and adverse inflammatory response. Protective inflammatory response against invasion of pathogenic microbes including active immunisation is described. Adverse inflammation is characterized on the molecular and cellular level with the respect to specific characteristic of this type of inflammation in various clinical contexts. The special emphasize is given to the mechanism of immune systém in mouth cavity in the health in diseases. Various attempts how to modulate adverse inflammatory response including administration of biologics is described. Mechanism of action of different biological drugs to overcome cancer cell escape from immune surveillance are described. The primary and secondary immunodeficiencies, including HIV infection and AIDS are presented. The diagnostic procedures and the way how to modulate immune system in immunodeficient patients are given. The basic framework of immunological test used in clinical practice is explained. The indication and interpretation of these immunological tests is given in clinical context of differential diagnostic procedures.

Poslední úprava: Kalousová Jana (22.05.2024)

Cíl předmětu

The complex knowledge of the function of immune system as the principal integral body system and its role in both protective and adverse inflammation is gained in this subject. These informations are used in the context of clinical practice especially in the framework of differential diagnostic procedures. The special emphasize is given to understand modulation of immune system including active immunisation. All this knowledge is given in the context of stomatological practice.

Poslední úprava: Kalousová Jana (22.05.2024)

Literatura

Compulsory literature

Immunology, 9th Edition. Editoři: D. Male, S. Peebles, V. Male (ClinicalKey Student) https://www.lfhk.cuni.cz/Fakulta/Organizacni-struktura/Domaci-stranky/Lekarska-knihovna/E-knihy/

  

Recomended literature 

1. Krejsek J, Andrýs C, Krčmová I, Imunologie člověka, Garamon, 2016 ISBN 978-80-86472-74-4
2. Murphy K, Casey W, Janeway's Immunobiology, 9th Edition 9th Edition, Kindle Edition 2017, ISBN-13: 978-0815345053

 

Poslední úprava: Kalousová Jana (22.05.2024)

Požadavky ke zkoušce

Credit

Active participation in practicals and seminars. One seminar could be missed due to illness evidenced by physicion. 

Final multiple choice test passing.

Poslední úprava: Kalousová Jana (22.05.2024)

Sylabus

Lecturers

 

• Prof. Dr. Jan Krejsek, Ph.D.
• Prof. Dr. Ctirad Andrys, Ph.D.
• Assoc. Prof. Dr. Pavlina Kralickova, Ph.D.
• Eva Mala, MD.
• Jakub Novosad, MD., Ph.D.
• Dr. Ondrej Soucek, Ph.D.
• Dr. Vladimira Rezacova, Ph.D.

 

Lecture

 

1^st Principles of immune system function (Krejsek)

 

• genetic background of immune response, epigenetic influences
• natural barriers, microbiota
• cells, tissues and organs of immune system
• immunity as an integral part of protective and damaging inflammatory response

 

2^nd Innate immunity, basic characteristics (Malá)

 

• DAMP, PAMP signals, receptors PRR and their function
• initiation and development of the inflammatory response
• humoral mechanisms of innate immunity, interferons, complement system
• cellular mechanisms of innate immunity, phagocytosis, natural cytotoxicity

 

3^rd Specific immunity (Soucek, Novosad)

 

• TcR, BcR receptors
• gene rearrangement
• clonal selection hypothesis of specific immune response
• T cells differentiation
• HLA system, processing and presentation of antigenic fragments to T cells
• polarisation of T cells, Th1, Th2, Th17, Treg subsets of T cells
• B cells differentiation, antigen independent differentiation
• B cell differentiation after antigenic stimulation, isotypic switching, somatic mutation
• antibodies, molecular characteristics, dynamics of antibody production
• immune memory

 

4^th Mucosal and skin immunity, immunity of oral cavity (Krejsek)

 

• barrier function of mucosal surfaces
• gut microbiota, its contribution to mucosal and systemic immunity
• breast feeding, prebiotics, solid food introduction, probiotics
• nutrition and immunity, proinflammatory activity of adipose tissue
• skin immune system
• skin microbiota
• oral cavity

 

5^th Protective inflammation/Damaging inflammation (Malá)

 

• immune response to viral infections
• immune response to bacterial infections
• immune response to fungal and parasitic infections
• active immunisation, mechanisms of action, adjuvans
• autoimmunity, development
• immunopathology, mechanisms of development, hypersensitivity reactions
• immunopathological diseases, systemic, organ specific
• modulation of inflammation, biological therapy

 

6^th  Primary and secondary immunodeficiencies (Králíčková, Krejsek)

• inborn deffect of immunity
• diagnosis management
• ackquired immunodeficiencies
• immunopathogenesis
• treatment

7^th Cancer and inflammatory response, modulation of immunity (Soucek, Krejsek)

 

• protective inflammation is effectively controlling malignant cell proliferation
• some tumours can escape protective inflammation
• immunotherapy in oncology
• principles of active immunisation

 

 

 

 

Practical courses & seminars

Lecturers

• Prof. Dr. Jan Krejsek, Ph.D.
• Prof. Dr. Ctirad Andrys, Ph.D.
• Assoc. Prof. Dr. Pavlina Kralickova, Ph.D.
• Eva Mala, MD.
• Jakub Novosad, MD., Ph.D.
• Dr. Ondrej Soucek, Ph.D.
• Dr. Karolina Jankovicova, Ph.D.

Practical courses

1. Immunological techniques and their application in dentistry. (Soucek, Mala)
2. Immunopathological reactions, diagnosis and treatment of autoimmune immunopathological diseases. (Jankovicova, Novosad)
3. Allergy - allergic inflammation, manifestation, treatment. (Kralickova, Krejsek)

Poslední úprava: Kalousová Jana (22.05.2024)

Vstupní požadavky

No prerequisities are required.

Poslední úprava: Kalousová Jana (22.05.2024)