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Course_2023_flyer.pdf | Jan Kovář | |
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Poslední úprava: Jan Kovář (02.12.2022)
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Poslední úprava: Jan Kovář (02.12.2022)
80% participation at the course |
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Poslední úprava: Mgr. Jana Čechová (01.12.2021)
e-learning course. Registered participants will access the course materials on Moodle |
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Poslední úprava: Mgr. Jana Čechová (01.12.2021)
80% participation at the course, joint project elaboration and presentation |
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Poslední úprava: Jan Kovář (02.12.2022)
Course description and learning objectives:
The course (https://4euepilepsy.lf2.cuni.cz/course-program/) explores the neurobiology of epilepsy from basic and clinical perspectives. The main objectives of this course are to deepen your knowledge on the pathophysiology of epilepsy and seizure, introduce you to modern research tools that are used in epilepsy research and identify the current challenges and complex issues in epilepsy. The course is highly didactic and composed of lectures and interactive sessions where attention is paid to the active involvement of participants and close interaction between students and tutors. The faculty involves internationally recognized leaders in epilepsy research and clinical epileptology.
The course is international, and it is open to undergraduate and Ph.D. students from various research disciplines who are interested in epilepsy research. The course requires participants to have a basic background in neuroscience, basic knowledge of neuroanatomy at the microscopic and macroscopic levels. The preference will be given to participants who have bachelor level course on neurophysiology, neuroscience or similar topic/s
After the course the participant will be able to:
• Understand the cellular, network, molecular and metabolic processes that characterize the chronic epileptic tissue, epileptic neurons, pathological activity present between seizures and seizures.
• Describe how the mechanisms vary in various forms of epilepsy ranging from focal epilepsy to generalized one and epileptic encephalopathies.
• Recognize the mechanisms that are responsible for the development of epilepsy.
• Understand how various types of lesions lead to the development of epilepsy and seizures.
• Understand how brain development and brain aging affect the brain susceptibility to develop epilepsy and the underlying mechanism.
• Understand the basic principles of various research techniques and what information they provide to gain insight into the pathophysiological mechanisms of epilepsy.
• Recognize how understanding the pathophysiological mechanisms and pathogenesis of epilepsy is relevant for understanding the effect of currently available anti-seizure medication and developing new diagnostic techniques and epilepsy therapy.
• Identify the current challenges of epilepsy research
• Understand the needs of people with epilepsy and their expectations from the research
Course schedule
23rd February 2023 16:00-17:30 CET Introduction to the course Marco de Curtis, Maria Paola Canevini, Piotr Suffczynski and Premysl Jiruska 17:40-19:10 CET Lecture: Introduction to human epilepsy Marian Galovic and Petr Marusic
2nd March 2023 16:00-17:30 CET Interactive session: Seizures and epilepsy Marian Galovic, Shilpa Kadam, Vadym Gnatkovsky, Maria Paola Canevini and Petr Marusic 17:40-19:10 CET Lecture: Epileptic neurons and epileptic networks Premysl Jiruska and Piotr Suffczynski
9th March 2023 16:00-17:30 CET Interactive session: Epileptic neuron and neural circuits Piotr Suffczynski and Premysl Jiruska 17:40-19:10 CET Lecture: The role of glia, inflammation and metabolism in epilepsy Erwin van Vliet and Jakub Otahal
16th March 2023 16:00-17:30 CET Interactive session: Glia and inflammation Erwin van Vliet and Jakub Otahal 17:40-19:10 CET Lecture: Research tools – electrophysiology and imaging Christos Lisgaras and Jakub Otahal
23th March 2023 16:00-17:30 CET Interactive session: Imaging in epilepsy Christos Lisgaras and Jakub Otahal 17:40-19:10 CET Lecture: Research tools – morphology, biochemistry, molecular biology Julika Pitsch and Katja Kobow
30th March 2023 16:00-17:30 CET Interactive session: How to study brain tissue morphology Julika Pitsch and Katja Kobow
17:40-19:10 CET Lecture: Research tools – morphology, biochemistry, molecular biology Julika Pitsch and Katja Kobow
6th April 2023 16:00-17:30 CET Interactive session: EEG interpretation of epileptic activity Vadym Gnatkovsky, Petr Marusic and Christos Lisgaras 17:40-19:10 CET Lecture: Epileptogenesis – molecular, cellular, and network reorganization Shilpa Kadam, Nihan Carcak and Simona Balestrini
13th April 2023 16:00-17:30 CET Interactive session: Epileptogenesis in developing brain Shilpa Kadam, Nihan Carcak and Simona Balestrini 17:40-19:10 CET Lecture: Focal epilepsy – neuropathological substrates and underlying mechanisms Katja Kobow and Gilles Huberfeld
20th April 2023 16:00-17:30 CET Interactive session: Interpretation of histological findings – identify the lesion Katja Kobow, Angelika Mühlebner and Lucas Hoffmann 17:40-19:10 CET Lecture: Neurobiological aspects of generalized epilepsies Gilles Huberfeld, Piotr Suffczynski
27th April 2023 16:00-17:30 CET Interactive session: Experimental studies and data interpretation in genetic epilepsies Massimo Mantegazza and Cristina Ruedel-Reschke 17:40-19:10 CET Lecture: Epileptic encephalopathies Simona Balestrini
4th May 2023 16:00-17:30 CET Interactive session: From diagnosis to treatment in people with epilepsy Marian Galovic, Simona Balestrini, Maria Paopla Canevini 17:40-19:10 CET Lecture: Animal models of seizures and epilepsy Nihan Carcak, Erwin van Vliet and Christos Lisgaras
11th May 2023 16:00-17:30 CET Interactive session: Choose the best model for your experiments Nihan Carcak and Cristina Ruedel-Reschke 17:40-19:10 CET Lecture: Anti-seizure medications and therapeutic approaches Cristina Ruedel-Reschke and Simona Balestrini
18th May 2023 16:00-17:30 CET Interactive session: Design and test new drug or treatment Cristina Ruedel-Reschke and Stephanie Derdewardeere 17:40-19:10 CET Lecture: Future therapeutic approaches Gabriele Lignani
25th May 2023 16:00-17:30 CET Lecture: Epilogue – 20 mysteries that should be solved in epilepsy Marco de Curtis
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