Molekulární a buněčné zobrazování (MI) v biomedicínských oborech - MC240P54E

• Anglický název: Molecular Imaging in Biomedicine
• Zajišťuje: Katedra anorganické chemie (31-240)
• Fakulta: Přírodovědecká fakulta
• Platnost: od 2018
• Semestr: letní
• E-Kredity: 3
• Způsob provedení zkoušky: letní s.:
• Rozsah, examinace: letní s.:2/0, Zk [HT]
• Počet míst: neomezen
• Minimální obsazenost: 10
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: zrušen
• Jazyk výuky: angličtina
• Poznámka: povolen pro zápis po webu
• Garant: Mgr. Vít Herynek, Ph.D.

Anotace

čeština

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (06.03.2012)

Tento předmět je vyučován v angličtině. Stejný předmět vyučovaný v češtině má kód MC240P54.

angličtina

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (13.11.2013)

Molecular and cellular imaging (MI) in biomedical disciplines
Magnetic resonance imaging (MRI) is mainly understood as a method for description of morphological changes in brain and other organs by means of magnetic resonance phenomena (MR). However, apart from information from structural MR imaging, further information related to function and biochemical composition of tissues can be obtained from special MR techniques and other imaging modalities, such as optical imaging, computed tomography, positron emission tomography and many others. Currently, the research is now focused on MR applications which enable the study of pathophysiological changes of tissues at molecular level. First group of methods are techniques of in-vivo MR spectroscopy, which deal with investigation of chemical structure and concentration of biochemical compounds in tissues in-vivo. Second group of methods are techniques based on tracking of signal of specific contrast agents which are bound to specific cellular structures, thus enabling indirect observation of specific biochemical compounds in tissues or movement and destiny of cells in the living organism. Molecular and cell imaging in biomedicine is a wide field which extends to various disciplines, such as fields of basic research describing underlying physical phenomena, chemical disciplines of synthesis of specific contrast agents and biological and clinical applications.
Recommended range of participants:
This course is intended for students of basic course of natural science, PhD students in biomedicine, neuroscience and other related fields.

Literatura

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (12.10.2013)

Ján Weis, Peter Bořuta: Úvod do magnetickej rezonancie, Bratislava 1998

A. E. Merbach and É. Tóth eds.: The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, John Wiley & Sons 2001.

Požadavky ke zkoušce

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (12.10.2013)

Exam is combined – written and oral form – and follows the syllabus.

Sylabus

čeština

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (06.03.2012)

Tento předmět je vyučován v angličtině. Stejný předmět vyučovaný v češtině má kód MC240P54.

angličtina

Poslední úprava: doc. RNDr. Vojtěch Kubíček, Ph.D. (13.11.2013)

Molecular and cellular imaging in biomedicine (MI)

1. Introduction to molecular imaging - definition of MI, position of magnetic resonance (MR) with respect to other molecular imaging modalities

2. Clinical and experimental methods of molecular imaging - particularities and ethical guidelines for procedures in medicine and biomedicine

3. Principles of MR imaging and MR spectroscopy - MR imaging sequences and their application

4. Introduction to MR spectroscopy - basic parameters of MR spectra, relaxation times, diffusion coefficients etc. (from hardware to relaxation times)

5. MR spectroscopic sequences and their application

6. Clinical protocol of MR spectroscopic examination - quality control

7.-8. Methods post-processing and quantification of MR spectra - quantitative and qualitative assessment of spectra, subjective and objective spectral quantitation (LCModel, MRUI)

9. Metabolites observed by in-vivo MR spectroscopy - 1H, 31P, 13C spectroscopy

10. Biochemical pathways - metabolites detectable by in-vivo MR spectroscopy, age dependence of metabolite concentrations

11. Clinical applications of MR spectroscopy - brain tumors

12. Clinical applications of MR spectroscopy - epilepsy, psychiatry, inflammatory diseases, ischemia

13. MR imaging with contrast agent - MR relaxometry

14. MR imaging sequences for MI and their application

15. Contrast agents for MR imaging - methods for preparation and properties of contrast agents

16. Paramagnetic contrast agents - Gd, lanthanides and others

17. Superparamagnetic contrast agents - iron oxides

18. Bimodal contrast agents - for MR imaging, optical imaging and PET

19. Preparation and labeling of cells for cell imaging - STEM cells, beta cells

20. Techniques for transplantation of cells and in-vivo MR experiments

21. Tracking of position of transplanted cells and their destiny

22. Labeling of cells in-vivo - specific contrast agents

23.-24. Combination of MR imaging, optical imaging and radionuclide methods for MI - instruments, data co-registration

25.-26. Visit of department of clinical and experimental MI IKEM - MR imaging, optical imaging