Tento předmět je vyučován v angličtině. Stejný předmět vyučovaný v češtině má kód MC240P48.
Poslední úprava: Kubíček Vojtěch, doc. RNDr., Ph.D. (12.10.2013)
Introduction to coordination chemistry and definition of concepts, e.g. coordination number, chelation effect, donor atom. Ligand classification. Chemical bond in coordination compounds (ligand field theory) and explanation of some properties of complexes (spectral, magnetic, redox behavior). Chemical behavior of complexes, thermodynamic stability and kinetically labile and inert complexes. Examples of different kinds of coordination compounds and their utilization in practice (catalysis, analytical chemistry). Bioinorganic chemistry and metal complexes in medicine.
Introduction to supramolecular chemistry. Classification of supramolecular "host–guest" (receptor–substrate) compounds. Thermodynamic and kinetic selectivity. Nature of supramolecular interactions (ion–ion, ion–dipole, dipole–dipole, Hydrogen bonding, Cation-π interaction, "π-π stacking", Van der Waals forces, Hydrophobic effects). Supramolecular chemistry of life. Application in medicine.
Poslední úprava: Kubíček Vojtěch, doc. RNDr., Ph.D. (12.10.2013)
LIPPARD J., BERG J.M.: Principles of Bioinorganic Chemistry, University Science Books, 1994.
STEED J.W., ATWOOD J.L.: Supramolecular Chemistry, John Wiley&Sons, New York 2000.
Poslední úprava: Kubíček Vojtěch, doc. RNDr., Ph.D. (12.10.2013)
Požadavky ke zkoušce
Kombinovaná zkouška, po napsání písemné části náleduje část ústní.
Poslední úprava: Lukeš Ivan, prof. RNDr., CSc. (09.11.2011)
Sylabus -
Tento předmět je vyučován v angličtině. Stejný předmět vyučovaný v češtině má kód MC240P48.
Poslední úprava: Kubíček Vojtěch, doc. RNDr., Ph.D. (08.10.2013)
1. Introduction to coordination chemistry 1.1. Coordination compounds, basic concepts 1.2. Coordination number, stereochemistry of complexes, chelates 1.3. Donor atoms and kinds of ligands
2. Bonding in coordination compounds 2.1. Transition and inner transition metals (lanthanoids) 2.2. Chemical bond in coordination compounds 2.2.1. Crystal and ligand field theory 2.2.2. Ligand spectrochemical series 2.2.3. Stable electronic configurations 2.3. Absorption electronic spectra of complexes 2.4. Magnetic properties of complexes 2.5. Redox properties of complexes
3. Properties of coordination compounds 3.1. Stability constants 3.2. Kinetic behavior of complexes 3.3. Reactivity of coordination compounds
4. Kinds of coordination compounds and their importance 4.1. Aquacomplexes, ammincomplexes 4.2. Organometallic compounds 4.3. Homogeneous catalysis, examples of catalytic cycles 4.4. Complexes in analytical chemistry 4.5. Principles of bioinorganic chemistry 4.5.1. Role of metal ions in living systems, metalloenzymes 4.5.2. Metal metabolism 4.5.3. Oxygen and metal ion transports 4.5.4. Electron transfer in proteins 4.5.5. Utilization of metal in human medicine (cancerostatics and contrast agents)
5. Introduction to supramolecular chemistry 5.1. Classification of supramolecular "host–guest" (receptor–substrate) compounds 5.2. Thermodynamic and kinetic selectivity 5.3. Nature of supramolecular interactions (ion–ion, ion–dipole, dipole–dipole, Hydrogen bonding, Cation-π interaction, "π-π stacking", Van der Waals forces, Hydrophobic effects) 5.4. Supramolecular chemistry of life 5.5. Application in medicine
Poslední úprava: Kubíček Vojtěch, doc. RNDr., Ph.D. (08.10.2013)
