Antibiotika – přehled přípravků, význam pro léčbu, důsledky pro celou společnost
Cílem kurzu je seznámit posluchače s problematikou antibiotik z různých hledisek. V přednáškách věnovaných systematice budou probrány jednotlivé skupiny antibiotik z hlediska chemické struktury, mechanismu působení, spektra účinku, podstaty získané rezistence, farmakokinetiky, nežádoucích účinků a klinického využití. V ostatních přednáškách budou podrobněji diskutovány souvislosti a důsledky antibiotické léčby.
Poslední úprava: Lichá Irena, RNDr., CSc. (13.02.2018)
Antibiotics - significance, chemical structure, biosynthesis, mechanism of action and resistance
It is the aim of the course to provide information on the significance of antibiotics in modern mikrobiology. Infectious diseases are still responsible for up to 40 % of deaths worldwide, due mainly to an increasing resistance to chemotherapeutics, antibiotics in particular. In the course, antibiotics are classified according to their origin, chemical structure, mechanism of action and genetic control of antibiotic resistance and biochemical mechanisms of resistance. Attention is also paid to the biosynthesis of new, particularly hybrid antibiotics, by means of genetic engineering and combinatorial biochemistry.
References:
Grafe U.: Biochemie der Antibiotika, Spektrum Akademischer Verlag, Heidelberg--Berlin--New York, 1992.
Strohl W.R. (ed.): Biotechnology of Antibiotics, Marcel Dekker, New York--Basel--Hong Kong, 1997.
Kleinkauf H. and von Dohren (eds.): Biotechnology, Volume 7, Products of Secondary Metabolism, VCH Verlagsgesselschat, Weinheim, 1997.
Ciba Foundation Symposium: Antibiotic Resistance: Origins, Evolution, Selection and Spread. John Wiley & Sons, Chichester--New
York--Weinheim--Brisbane--Singapore--Toronto, 1997.
Georgie W.A. Milne: Ashgate Handbook of Anti-infective Agents. An International Guide to 1600 Drugs in Current Use. Ashgate Publishing Limited, Aldershot, 2000.
Poslední úprava: Lichá Irena, RNDr., CSc. (13.02.2018)
Literatura -
Literatura: Jiří Beneš: ANTIBIOTIKA: systematika, vlastnosti, použití. Praha: Grada, 2018.
Poslední úprava: Beneš Jiří, prof. MUDr., CSc. (13.03.2019)
Grafe U.: Biochemie der Antibiotika, Spektrum Akademischer Verlag, Heidelberg--Berlin--New York, 1992.
Strohl W.R. (ed.): Biotechnology of Antibiotics, Marcel Dekker, New York--Basel--Hong Kong, 1997.
Kleinkauf H. and von Dohren (eds.): Biotechnology, Volume 7, Products of Secondary Metabolism, VCH Verlagsgesselschat, Weinheim, 1997.
Ciba Foundation Symposium: Antibiotic Resistance: Origins, Evolution, Selection and Spread. John Wiley & Sons, Chichester--New York--Weinheim--Brisbane--Singapore--Toronto, 1997.
Poslední úprava: Schierová Michaela, RNDr., Ph.D. (24.10.2019)
Požadavky ke zkoušce - angličtina
The subject will be completed with an oral exam on the basic knowledge of the subjects being lectured.
Poslední úprava: Schierová Michaela, RNDr., Ph.D. (24.10.2019)
Pharmacokinetics of antibiotics in human organism, therapeutic monitoring of ATB, terms describing the effect of antibiotics. PK / PD principles.
Another ATB inhibiting bacterial cell wall formation (glycopeptides). ATB damaging the cell membrane of bacteria (peptide and lipopeptide ATB, including polymyxins, aminoglycosides).
ATB acting on the level of nucleic acids (fluoroquinolones, rifamycins).
Pathophysiology and therapy of sepsis. Importance of bactericidal antibiotics.
ATB acting at the level of ribosomes (tetracyclines, macrolides, lincosamides and others).
Internship at the Microbiology Department (for applicants).
