This seminar extends the basic information about cytogenetics taught during the compulsory biology seminar in the first year. After a brief summary of the historical milestones in the cytogenetic field and an overview of the use of cytogenetic methods in present medicine, relevant examples from the areas of prenatal, postnatal and cancer cytogenetics are discussed.
Poslední úprava: Buriánková Martina, Mgr. (16.05.2018)
Literatura - angličtina
I. D. Young: Medical genetics, Oxford University Press, 2010.
D. E. Rooney: Human Cytogenetics - Constitutional Analysis - Malignancy and Acquired Abnormalities, Oxford University Press, 2001.
J. L. Huret et al.: Atlas of Genetics and Cytogenetics in Oncology and Haematology [online]. http://atlasgeneticsoncology.org/
Poslední úprava: Buriánková Martina, Mgr. (16.05.2018)
Kontroly studia předmětu a podmínky pro jejich úspěšné vykonání, způsob hodnocení
Aktivní účast.
Poslední úprava: Buriánková Martina, Mgr. (25.10.2019)
Sylabus - angličtina
Morgan's fly room; Tjio and Levan – the correct number of chromosomes in humans; Lejeune and Jacobs - supernumerary copy of chromosome 21 in Down syndrome patients; Nowell and Hungerford – Philadelphia chromosome and leukemia; methodology of chromosome karyotyping; G and R banding; FISH and CGH methods; Denver and Paris cytogenetic nomenclature; ISCN and common chromosomal abnormalities; amniocentesis and prenatal screening of chromosomal abnormalities; chorionic villi sampling; microdeletion and microduplication syndromes; oncocytogenetics; the story of Gleevec; biological therapy in cancer.
Poslední úprava: Buriánková Martina, Mgr. (16.05.2018)
