Biology and Genetics 1 - B83009

• Anglický název: Biology and Genetics 1
• Zajišťuje: Ústav biologie a lékařské genetiky 1. LF UK a VFN (11-00160)
• Fakulta: 1. lékařská fakulta
• Platnost: od 2023
• Semestr: letní
• Body: 7
• E-Kredity: 7
• Způsob provedení zkoušky: letní s.:
• Rozsah, examinace: letní s.:2/2, Z [HT]
• Rozsah za akademický rok: 60 [hodiny]
• Počet míst: neomezen
• Minimální obsazenost: neomezen
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: vyučován
• Jazyk výuky: angličtina
• Způsob výuky: prezenční
• Vysvětlení: doc. MUDr. František Liška, Ph.D. ; [e-mail]
• Další informace: http://biol.lf1.cuni.cz/menu.htm
• Staré označení: 5
• Poznámka: povolen pro zápis po webu
• Garant: prof. MUDr. Ondřej Šeda, Ph.D.
• Atributy: Lékařství; Teoretický předmět
• Záměnnost : B80005
• Je prerekvizitou pro: B83121, B83123

Anotace

čeština

Biologie prokaryotní a eukaryotní buňky. Mitóza, meióza, regulace. Mendelovská dědičnost. Multifaktoriální dědičnost. Genetická analýza. Genová vazba. Genealogie. Chromozómy a chromozómové aberace.

Poslední úprava: Kohútová Vladislava, Ing. (17.05.2018)

angličtina

Biology of procaryotic and eucaryotic cell. Mitosis, meiosis, regulation. Mendelian inheritance. Multifactorial inheritance. Genetic analysis. Gene linkage. Genealogy. Chromosomes and chromosomal aberrations.

Poslední úprava: Kohútová Vladislava, Ing. (17.05.2018)

Literatura

čeština

http://ublg.lf1.cuni.cz/en/recommended-literature

Poslední úprava: Kohútová Vladislava, Ing. (17.05.2018)

Sylabus

Lectures

Introduction, Genetics and Genomics in Medicine

Genetic aspects of mitosis, meiosis, regulation, disturbances

Structure and function of eukaryotic chromosomes, human karyotype, cytogenetic techniques

Numerical and structural chromosomal aberrations, etiology and phenotyped

Cell cycle regulation

Genealogy, traits with Mendelian mode of inheritance in pedigrees

Nonmendelian phenomena in medical genetics

Genetic linkage, its evaluation, importance in medicine

Gene interactions - changes in segregation ratios

Multifactorial inheritance, heritability

Biology and genetics of viruses, prokaryotes and eukaryotes

Ecogenetics, Pharmacogenetics, Nutrigenetics

Practical exercises

Genetics in medicine

Mitosis

Meiosis

Numerical chromosomal aberrations

Structural chromosomal aberrations

Clinical cytogenetics

Monohybridism, dihybridism

Types of inheritance in the pedigree, examples of monogenic traits in human

Genetic linkage and its assessment in experiment and genealogy

Polygenic and multifactorial inheritance, risk assessment, trait examples

Genetic interactions

Formal genetics and cytogenetics in practice

Poslední úprava: Kolářová Jana (07.02.2020)

Vstupní požadavky

čeština

Studenti se dostaví v den zahájení výuky do "Rotundy" Ústavu biologie a lékařské genetiky 1. LF UK a VFN, Albertov 4, Praha 2.

S sebou:

Návody k praktickým cvičením (viz doporučená literatura)

a nejlépe A4 nelinkovaný sešit k vedení protokolů.

Bílý plášť a přezutí nejsou nutné.

Poslední úprava: Kohútová Vladislava, Ing. (17.05.2018)

angličtina

• Practical exercises will take place in Rotunda (or Round Auditory, ID in SIS is BIOLS1), which is located on the first floor of the Purkyně Institute (Albertov 4), in the right wing at the end of the corridor. On our web you can find the weekly schedule of the practical training plus assignment of study groups to particular weekdays and teachers. You do not need lab coats, but you may need a pen and paper (or something to write on) and a calculator.

  For each practical training, you will be required to fill in a protocol. Protocols and presentations from practical trainings will be posted here in MS Teams under the “Files” tab. Please store your filled-in protocols, they may be needed for your credit. You will also need to pass 3 tests (cytogenetics, formal genetics and credit test) which will be written on computers using system “ROGO”. During the first week of practical training, you will have an opportunity to get acquainted with ROGO. It should be stressed beforehand that for the computer tests, you will not be allowed any materials with the exception of blank paper, pen and a calculator, all without data connection (i.e. no mobile phones as calculators). For further information, please contact your group teacher(s).

  Lectures will also be in presence format, in the Large Auditory of the Purkyně Institute. You can find the lecture schedule on our web page. In addition to the presence form, there may be a possibility to obtain access to some of the previously recorded videos from the lectures delivered during the distance learning. Further information should be available soon.

  Biology and Genetics 1 is concluded by obtaining the credit, for which you need:

  1. attendance to practical training: 1 absence is tolerated without explicit reasons, 2 more absences could be tolerated if sufficient objective justification is given, with more absences, please refer to your group teacher or appeal to me or to the head of the Institute. Filled-in protocols may be important in complicated cases;
  2. all 3 computer tests passed (with approximately 60% above the random mark);

Poslední úprava: Šeda Ondřej, prof. MUDr., Ph.D. (07.03.2023)