SubjectsSubjects(version: 944)
Course, academic year 2023/2024
   Login via CAS
Pharmaceutical Chemistry I - GF341
Title: Farmaceutická chemie I
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: winter
Points: 0
E-Credits: 4
Examination process: winter s.:
Hours per week, examination: winter s.:42/70, C [HS]
Capacity: unlimited / 240 (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: deregister from the credit exam date if a requisite was not fulfilled
Guarantor: prof. PharmDr. Martin Doležal, Ph.D.
Comes under: 3.ročník 2023/24-Farmacie
Co-requisite : GF339
Pre-requisite : GF141, GF293, GF299
Is co-requisite for: GF342, GF339, GF244, GF344
Annotation -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (10.10.2023)
Pharmaceutical Chemistry is a specific pharmaceutical subject representing the link between chemical and biological disciplines. Its task is to provide students with a complex understanding of drug and auxiliary substance chemistry. The drugs are studied from the point of view of their rational selection and preparation, quality criteria, suitable ways of storage, structure-activity and structure-metabolism relationships, and practical usage. The brief information concerning mechanisms of drug action covered in this subject forms the basis for a more profound study of this topic in pharmacology. This subject belongs to the state final examination group of subjects.
Course completion requirements -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (10.10.2023)

mastering the subject matter according to the syllabus.

Literature -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (10.10.2023)


  • . . In Williams, David A., Lemke, Thomas L. (eds.). Principles of medicinal chemistry . Baltimore: Lippincott Williams & Wilkins, 2002, s. -. ISBN 0-683-30737-1..

Syllabus -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (10.10.2023)

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system:

  • General anesthetics
  • Sedative-hypnotics
  • Anticonvulsants
  • Neuroleptics
  • Anxiolytics
  • Antidepressants
  • Psychostimulants
  • Hallucinogens
  • Antiparkinsonian agents
  • Opiate analgesics
  • Nonopiate analgesics
  • Nonsteroidal anti-inflammatory agents
  • Antiemetics
  • Antitussives
  • Expectorants

Drugs affecting the peripheral nervous system

  • Local anesthetics
  • Skeletal muscle relaxants
Charles University | Information system of Charles University |