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Course, academic year 2024/2025
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Organic Chemistry II - GAF299
Title: Organic Chemistry II
Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: summer
Points: 0
E-Credits: 5
Examination process: summer s.:combined
Hours per week, examination: summer s.:28/20, C+Ex [HS]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: doc. Dr. Russell Richard Anthony Kitson
Co-requisite : GAF390, GAF391
Incompatibility : GAF133, GAF292
Interchangeability : GAF133, GAF292
Is co-requisite for: GAF243, GAF229, GAF050
Is pre-requisite for: GAF141, GAF300, GAF244, GAF341
Is interchangeable with: GAF133
Annotation -
Preparatory discipline for profile subjects taught at the Faculty of Pharmacy. Themes: System of organic compounds: hydrocarbons, halogen derivatives, alcohols, phenols, ethers, amines, sulfur and silicon compounds, carbonyl compounds, carboxylic acids and their derivatives, substituted carboxylic acids and their derivatives, carbonic acid derivatives, organometallic compounds.
Last update: Vinšová Jarmila, prof. RNDr., CSc. (20.02.2024)
Course completion requirements -

The condition to obtain the credit is 100% attendance at the seminars and at least 60% points from tests written during the semester or from credit test. Exam has written test (minimum 60% points) and oral part.

2 Exam Questions: 

Drug formula, its name, physical and chemical properties

System: 

1.    Alkanes, cycloalkanes, nomenclature, synthesis, reactivity

 

2.     Alkenes, nomenclature, preparation (Zaitsev´s rule), reactivity (Markovnikov´s rule and anti-Markovnikov´s rule), reactivity

 

3.    Dienes, polyenes, Diels-Alder reaction, Alkynes, nomenclature, preparation and reactivity

 

4.    Benzene, aromaticity of compounds, electrophilic aromatic substitution, effect of substituents on electrophilic aromatic substitution

 

5.    Nucleophilic aromatic substitution.

 

6.    Alkylhalides, nomenclature, preparation, reactivity of halogenalkanes (substitution, elimination, comparison with arylhalogenates)

 

7.    Alcohols, ethers, nomenclature, preparation, reactivity

 

8.    Aldehydes, ketones, nomenclature, synthesis, reactivity

 

9.     Reaction of aldehydes and ketones with N-bases, O-bases and S-bases, Haloform reaction, oxidation reduction of carbonyl compounds

 

10. Reactivity of carbonyl compounds with C-H acids, Aldol and Crossed Aldol reactions (α-carbon)

 

11. Carboxylic acids, nomenclature, preparation and their reactivity

 

12. Acylchlorides, nomenclature, synthesis and their reactivity

 

13. Anhydrides and esters, nomenclature, synthesis and their reactivity

 

14.Amides and nitriles, nomenclature, synthesis and their reactivity

 

15. Reactivity of benzenediazonium salts, azo-coupling reactions of diazonium salts with activated aromatic compounds

 

16. Reactivity of a,b-unsaturated carbonyl compounds

 

17. Oxidations

 

18. Reductions

 

19. Molecular rearrangements

 

20. Addition polymers

 

21. Condensation polymers

 

22. Organometallic compounds - preparation, reactivity

 

23. Amines, nomenclature, synthesis, reactivity

 

24. Sulphur containing compounds

 

25. Heterocyclic amines

 

26. b-Dicarbonyl compounds and their reactivity (The Claisen condensation, Malonic ester synthesis, Knoevenagel condensation, Michael addition, Mannich reaction)

 

27. Phenols - synthesis, reactivity

 

28.Amino acids, nomenclature, preparation, reactivity

 

Last update: Vinšová Jarmila, prof. RNDr., CSc. (20.02.2024)
Literature -

Obligatory:

  • Solomons, T. W. Graham Fryhle, Craig B.. Organic chemistry. Hoboken: John Wiley, 2007, 1191 s. ISBN 0-471-68496-1.
  • Wade, L. G.. Organic chemistry. Englewood Cliffs: Prentice Hall Int., 1987, 1233 s. ISBN 0-13-642588-7.
  • McMurry, Susan McMurry, John. Study guide & student solutions manual for John McMurry's Organic chemistry. Belmont: Thomson-Brooks/Cole, 2008, 900 s. ISBN 978-0-495-11268-6.

Last update: prepocet_literatura.php (19.09.2024)
Syllabus -

System of organic compounds

Alkanes, cycloalkanes, alkenes, polyenes, alkynes, aromates, halogen derivatives, alcohols, phenols, ethers, amines, organic compounds of sulphur and silicon, carbonyl compounds and their reactivity, carboxylic acids and their derivatives, acylchlorides, anhydrides, esters, amides, nitriles, amino acids, organometallic compounds, heterocyclic compounds.

Last update: Vinšová Jarmila, prof. RNDr., CSc. (20.02.2024)
 
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