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Course, academic year 2024/2025
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Technology of Synthetic Drugs - GAF243
Title: Technology of Synthetic Drugs
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: summer
Points: 0
E-Credits: 3
Examination process: summer s.:written
Hours per week, examination: summer s.:28/14, C+Ex [HS]
Capacity: unknown / unknown (40)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Explanation: (F 3.r.)
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. PharmDr. Martin Doležal, Ph.D.
Co-requisite : GAF299
In complex pre-requisite: GAF1002
Annotation -
The lectures and practical training follow the subjects of Organic Chemistry II, Pharmaceutical Chemistry I and II. The students get acquainted with the theory and methodology of chemical processes which are important for the drug production.
Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Course completion requirements - Czech

Absolvování praktických cvičení v předepsaném rozsahu

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Literature -

Vardanyan R.S., Hruby V.J.: Synthesis of essential drugs. Firts edition 2006, Elsevier, Amsterdam, 617 pp. ISBN-13: 978-0-444-52166-8

Last update: Doležal Martin, prof. PharmDr., Ph.D. (13.06.2008)
Syllabus -

Lectures

Introduction
History and development of the pharmaceutical industry, Good Manufacturing Practice, Technical documents in pharmaceutical industry - quality control system
Chemical processes used in the syntheses of drugs:
General reactions for: 
Oxidation (Oxidation of hydrocarbons, Oxidation of aromatic system, Oppenauer Oxidation) 
Reduction (Catalytic Hydrogenation, Béchamp Reduction, Clemmensen Reduction, Wolff-Kishner Reduction, Meerwein-Ponndorf-Verley Reduction) 
Condensation (Aldol Condensation, Perkin Reaction, Claisen-Smidt Condensation, Knoevenagel Condensation, Claisen Condensation, Dieckmann Reaction, Mannich Reaction) 
Addition (Addition on bond carbon-carbon, Diels-Alder Reaction, Michael Reaction, Addition on bonds carbon-oxygen and carbon-nitrogen) 
Polymeration and polycondensation 
Isomerization and rearrangement (Wagner-Meerwein Rearrangement, Wolff Rearrangement, Arndt-Eistert Synthesis, Benzilic Acid Rearrangement, Hofmann Reaction, Curtius Rearrangement, Schmidt Reaction)
Special synthetic reactions for: 
 Preparation of bond carbon-carbon (Friedel-Crafts Reaction, Gattermann Aldehyde Synthesis, Houben-Hoesch Reaction, Knorr Pyrazole Synthesis, Grignard Reaction, Reformatskii Reaction, Wurtz-Fittig Reaction, Blanc (Chloromethylation) Reaction) 
Preparation of bond carbon-hydrogen (Dehalogenation, Dehydroxylation, Deamination, Decarbonylation, Decarboxylation, Desulfonylation) 
Preparation of bond carbon-halogen (Halogenation, Finkelstein Reaction, Sandmeyer Reaction, Gattermann Reaction) 
Preparation of bond carbon-oxygen (Williamson Synthesis) 
Preparation of bond carbon-nitrogen 
Preparation of bond carbon-sulfur

Practical Training
Syntheses of representative types of drugs (Sulfanilamides, Benzocain, Clofibrat, Disulfiram, Etophyllin etc.). Excursion in a pharmaceutical manufacturing company.

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
Teaching methods -

The training in Technology of Synthetic Drugs runs in 6th semester of pharmacy course in lectures and practical trainings. The subject is finished by a written exam.

Last update: Doležal Martin, prof. PharmDr., Ph.D. (07.02.2022)
 
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