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Course, academic year 2024/2025
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Analytical Chemistry - GAF300
Title: Analytical Chemistry
Guaranteed by: Department of Analytical Chemistry (16-16140)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: winter
Points: 0
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:14/42, C [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Note: deregister from the credit exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: doc. Burkhard Horstkotte, M.Sc., Dr.
Comes under: 2.ročník 2024/25 Pharmacy (EN19)
Pre-requisite : GAF299
Interchangeability : GAF139
Is co-requisite for: GAF301, GAF395, GAF302
Is interchangeable with: GAF139
Annotation -
The aim of the subject is to provide the students with firm and sufficiently wide theoretical and methodological fundamentals for pursuing (in a rational way) chemical analysis of inorganic and organic substances. The teaching is focused on the explanation of theoretical aspects of instrumental methods. In practical training individual approach of students to solving analytical problems is required.
Last update: Horstkotte Burkhard, doc., M.Sc., Dr. (02.08.2024)
Course completion requirements -

Credits are base on:

Practical course

  1. Participation in all practical classes – (missing practical must be revisited or it can be substituted if permitted by the teacher)

  2. Compliance with safety rules at work in the laboratory

  3. Submission of all reports of practical exercises

  4. Minimum 66% of points for correct results in practical tasks and for correct answers in the monitoring tests and in the credit test

Last update: Horstkotte Burkhard, doc., M.Sc., Dr. (02.08.2024)
Literature -

Obligatory:

  • . . In Christian, Gary D., Dasgupta, Purnendu K. Schug, Kevin. Analytical chemistry . Hoboken: Wiley, 2014, s. -. ISBN 978-0-470-88757-8..

Recommended:

  • . 2005. In Robinson, James W., Frame, Eileen M. Skelly Frame, George M.. Undergraduate instrumental analysis . New York

    : M. Dekker, 2005, s. -. ISBN 0-8247-5359-3..

Last update: prepocet_literatura.php (19.09.2024)
Syllabus -

Syllabus – Analytical Chemistry

Types of Analytical reactions

  • Basic types of analytical reactions. Selectivity and sensitivity of analytical reactions.

  • Analytical protolytic reactions. Buffers in analytical chemistry. Acids and bases in non-aqueous solvents.

  • Analytical complex-formation reactions and their equilibrium. Use of complex-formation reactions in analytical chemistry. Masking. Organic complex-formation reagents.

  • Analytical oxidation-reduction (redox) reactions, their equilibrium and kinetics. Catalytic and induced reaction.

  • Analytical precipitation reactions and their equilibrium. Extraction equilibrium.

Qualitative inorganic analysis

  • Detection and determination of selected cations and anions. Colour, precipitation and oxido-reduction identification reaction, group, selective and specific reagents.

  • Evaluation of qualitative analysis of simple inorganic compound.

Analysis of organic compounds

  • Methods of organic analysis. Elemental analysis: detection of C, H, N, S, O, and halogens in organic compounds. Determination of C, H, N, S, O, and halogens.

  • Functional analysis: detection of alcohols, phenols, amines, aldehydes and ketones, carboxylic acids, esters, amides, sulphonamides, sulphonic acids, hydrocarbons, nitro- and nitroso-compounds.

  • Identification and determination of hydrocarbons, alcohols, phenols, amines, aldehydes and ketones, carboxylic acids, esters, amides, sulphonamides, sulphonic acids, nitro- and nitroso-compounds. Analysis of organic salts.

  • Solubility of organic compounds - classification system, structure-solubility relationships and their analytical use.

Direct Methods of quantitative analysis

  • General procedures in quantitative analysis. Sample pre-treatment. Processing and evaluation of results of quantitative analysis.

  • Fundamentals and types of gravimetric methods.

  • Titrimetric (volumetric) analysis; direct titration, indirect titration, back-titration. Concentration of volumetric solutions and their standardisation.

Acidimetry and alkalimetry, acid-base indicators, titration in non-aqueous solvents. Chelatometry, chelatometric indicators. Permanganatometry. Iodimetry. Bromatometry. Dichromatometry. Argentometry. Mercurimetry.

 

ANALYTICAL CHEMISTRY - LABORATORY TRAINING PROGRAMME

1)      Safety rules. Techniques of qualitative analytical reactions. Group reactions. Selective and specific reactions.

2)      Analysis of solution of unknown composition. Detection of Na+, K+, NH4+, Ba2+, Ag+, Pb2+, Cu2+, Zn2+, Fe3+, Co2+, Ni2+, Al3+.

3)      Analysis of solution of unknown composition. Detection of SO42-, S2O32-, PO43-, BO2-Cl-, Br-, I-, SCN-, NO2-, NO3-.

4)      Overall qualitative analysis of a simple solid inorganic compound.

5)      Introduction to analysis of organic compounds.

6)      Qualitative elemental analysis (detection of C, H, N, S, halogens).

7)      Characterisation of an unknown organic compound by solubility test.

8)      Detection of functional groups: amines, aldehydes, ketones, esters, carboxylic acids. Detection of functional group in an unknown organic sample.

9)      Quantitative analysis – titration methods (introductory seminar, calculations).

10)  Alkalimetric titrations. Determination of a strong acid in a liquid sample.

11)  Chelatometric titrations. Preparation of a standard solution of disodium edetate. Preparation and standardisation of standard solution of zinc sulphate. Determination of Al3+ in a liquid sample by back-titration.

12)  Iodimetric titrations. Preparation and standardisation of standard solution of sodium thiosulphate. Determination of Cu2+ in a solid sample.

Last update: Horstkotte Burkhard, doc., M.Sc., Dr. (02.08.2024)
 
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