Pathological Physiology for Pharmacists - GAF137
Title: Pathological Physiology for Pharmacists
Guaranteed by: Department of Biological and Medical Sciences (16-16150)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: summer
Points: 0
E-Credits: 7
Examination process: summer s.:oral
Hours per week, examination: summer s.:42/14, C+Ex [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Explanation: (F,2.r.)
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. PharmDr. Petr Nachtigal, Ph.D.
Classification: >
Comes under: 2.ročník 2024/25 Pharmacy (EN19)
Co-requisite : GAF181
Is co-requisite for: GAF309, GAF155, GAF184
Is pre-requisite for: GAF339
Examination dates   SS schedule   
Annotation -
The subject Pathological physiology for Pharmacists comprises the general knowledge of pathological morphology and physiology, followed by the fundamentals of pathophysiological and all clinical manifestations of diseases the relation to pharmacy and drug use and effects.
Last update: Nachtigal Petr, prof. PharmDr., Ph.D. (17.02.2025)
Course completion requirements -

RULES FOR THE OBTAINING CREDIT

 There is a maximum of two absences in the seminar classes.

o Absences in seminar classes can be excused only by an official medical document in English or Czech.

 Suppose there are more than two absences (the official medical document in English or Czech must excuse all absences). In that case, the student must write and pass an extra written credit test to obtain credit for the subject.

o A credit test is a written test with 20 questions for the whole subject (multiple choice questions with one correct answer) performed in the last week of the summer semester.

o Students must gain at least 14 points to pass the credit test and obtain the credit.

o There are three maximum attempts to pass the credit test. If a student fails to pass a credit test, the student cannot pass the subject this academic year.

 Late arrival at seminars (5 or more minutes late 2 times and more) means an extra written credit test.

RULES FOR THE EXAM

 Obtaining credit is necessary to participate and pass the exam.

 There is an oral exam only

 Registration for exams is possible only via the SIS system

 The student will choose two questions from the list of questions for Pathological Physiology (available in Study materials)

 Teachers might ask additional questions from different areas of Pathological physiology

 All chosen and asked questions are equal concerning the validity of the exam and exam results (exam mark)

Last update: Nachtigal Petr, prof. PharmDr., Ph.D. (06.03.2025)
Literature - Czech

Povinná:

  • Huether, Sue E. McCane, Kathryn L. (eds.). Understanding pathophysiology. Saint Louis: Mosby, 2000, 1196 s. ISBN 0-323-00791-0.

  • Kaufman, Christian E. McKee, Patrick A. (eds.). Essentials of pathophysiology. Boston : Philadelphia: Little, Brown and company ; Lippincott Williams & Wilkins, , 799 s. ISBN 0-316-48405-9.

Last update: Nachtigal Petr, prof. PharmDr., Ph.D. (17.02.2025)
Syllabus -
  • Necrosis, pathophysiology, types of necrosis
  • Atrophy, pathophysiology, types of atrophy
  • Dystrophy, pathophysiology, types of dystrophy
  • Thrombosis, pathophysiology, types of thrombi
  • Pathophysiology of edema, embolism, metastasis, pathophysiology
  • Hyperemia, ischemia, hemorrhage, pathophysiology
  • Tumors, terminology, benign and malignant tumors
  • Anemia, causation of anemia
  • Leukopenia and leukocytosis
  • Leukemias, pathophysiology, types of leukemia
  • Inflammation, microscopic manifestation of inflammation, mediators of inflammation
  • Disorders of the primary hemostasis
  • Disorders of hemocoagulation
  • Ischemic heart disease, causation, angina pectoris, myocardial infarction
  • Arterial Hypertension, pathophysiology, pathophysiology
  • Pulmonary hypertension, Cor Pulmonale
  • Arrhythmia, pathophysiology, types of arrhythmia
  • Cardiac failure, pathophysiology, clinical manifestation
  • Atherosclerosis, risk factors, pathophysiology, clinical manifestation
  • Dyspepsia of stomach and gut
  • Acute gastritis, pathophysiology
  • Peptic ulcer disease, gastric ulcer, duodenal ulcer, pathophysiology
  • Colorectal cancer
  • Crohn´s disease, pathophysiology, pathophysiology
  • Ulcerative colitis
  • Pancreatitis, pathophysiology, pathophysiology
  • Liver insufficiency, consequences of the liver insufficiency
  • Acute and chronic bronchitis, pathophysiology
  • Emphysema and bronchiectasis
  • Asthma, pathophysiology, pathophysiology, clinical manifestation
  • Respiratory failure, pathophysiology, clinical manifestation
  • Lung cancer
  • Glomerulonephritis, pathophysiology, pathophysiology, clinical manifestation
  • Nephrotic/nephritic syndrome, pathophysiology
  • Acute renal failure, causation, clinical manifestation
  • Chronic renal failure, causation, clinical manifestation
  • Diabetes mellitus, types, acute and chronic clinical manifestation
  • Metabolic syndrome, characterization, clinical manifestation
  • Alteration of hypothalamic – pituitary system
  • Alteration of thyroid gland – hyperthyroidism, hypothyroidism
  • Addison disease, pathophysiology, clinical manifestation
  • Hyperaldosteronism (Conn Syndrome), pathophysiology, clinical manifestation, Pheochromocytoma, pathophysiology, clinical manifestation
  • Cushing syndrome, pathophysiology, clinical manifestation
  • Alterations of water metabolism, dehydratation, hyperhydration
  • Alterations of ions balance, sodium, potassium
  • Acidosis, pathophysiology, types of acidosis, compensation, clinical manifestation
  • Alkalosis, pathophysiology, types of alkalosis, compensation, clinical manifestation
  • Osteoporosis, osteomalacia, clinical manifestation
  • Fracture, bursitis, dislocation
  • Osteoarthrosis, rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute rheumatic fever
  • Low back pain
  • Gout
  • Systemic lupus erythematosus, pathophysiology, clinical complication
  • Amenorrhoea and dysmenorhea, pathophysiology
  • Cervical and brest cancers
  • Infertility
  • Preeclampsia
  • Prostatic disorders
  • Anorexia Nervosa
  • Anxiety Disorders, pathophysiology, clinical manifestation
  • Depression, pathophysiology, clinical manifestation
  • Bipolar affective disorder
  • Schizofrenia, pathophysiology, clinical manifestation
  • Multiple sclerosis, pathophysiology, clinical manifestation
  • Epilepsy, pathophysiology, clinical manifestation
  • Parkinson’s disease, pathophysiology, clinical manifestation

 

Last update: Nachtigal Petr, prof. PharmDr., Ph.D. (17.02.2025)
Learning outcomes

   

The subject Pathological Physiology for Pharmacists builds on the knowledge and skills acquired in the subjects General Biology, Microbiology, Immunology, and especially Morphology and Human Physiology.

After completing the course, students are familiar with basic pathological and medical terminology and can understand the pathophysiology of selected pathological conditions based on this terminology.

Learning Outcomes:

Based on the knowledge and skills acquired, learners will:

Ø  Define selected pathological terms describing pathological conditions such as necrosis, apoptosis, atrophy, dystrophy, hypertrophy, hyperplasia, inflammation, edema

Ø  Know the selected physiological and pathological values of blood parameters (e.g. glycaemia, cholesterolemia, pH)

Ø  Can use basic physiology and morphology to understand the pathophysiological processes of selected diseases of the cardiovascular, respiratory, digestive, excretory, endocrine, nervous, and reproductive systems, blood, and psychiatric conditions

Ø  Able to explain the etiopathogenesis, pathophysiology, and clinical symptoms of selected diseases:

o   the cardiovascular system, such as atherosclerosis, ischemic heart disease, arterial hypertension, metabolic syndrome, arrhythmias, cardiac seizures, and shock states

o   the respiratory system, such as ARDS, COPD, pulmonary oedema, and lung cancer

o   the reproductive system, such as menstrual disorders, breast, cervical, and prostate cancers

o   psychiatric and neurological disorders such as anxiety disorders, bipolar disorder, Alzheimer's disease, Huntington's disease, Parkinson's disease, and epilepsy

o   on the digestive system and metabolism, such as malnutrition, obesity, diabetes mellitus, icterus, liver fibrosis, pancreatitis, ulcer disease, idiopathic intestinal inflammation, colorectal cancer

o   Excretory system and pH disorders such as nephritic and nephrotic syndrome, renal failure, glomerulonephritis, acidosis, and alkalosis

o   endocrine system such as Addison's disease, Cushing's syndrome, Graves’ disease, Hashimoto's goiter, disorders of the hypothalamic-pituitary system 

 

Last update: Nachtigal Petr, prof. PharmDr., Ph.D. (06.03.2025)