SubjectsSubjects(version: 944)
Course, academic year 2023/2024
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Pathological Physiology for Pharmacists - GAF137
Title: Pathological Physiology for Pharmacists
Guaranteed by: Department of Biological and Medical Sciences (16-16150)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2021
Semester: summer
Points: 0
E-Credits: 7
Examination process: summer s.:oral
Hours per week, examination: summer s.:42/28, C+Ex [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: (F,2.r.)
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. PharmDr. Petr Nachtigal, Ph.D.
Classification: >
Comes under: 2.ročník 2023/24 AJ
Co-requisite : GAF181
Is co-requisite for: GAF309, GAF155, GAF184
Is pre-requisite for: GAF339
Annotation -
Last update: prof. PharmDr. Petr Nachtigal, Ph.D. (29.09.2021)
The subject Pathological physiology for Pharmacists comprises the general knowledge of pathological morphology and physiology, followed by the fundamentals of pathophysiological and all clinical manifestations of diseases the relation to pharmacy and drug use and effects.
Course completion requirements
Last update: prof. PharmDr. Petr Nachtigal, Ph.D. (29.09.2021)

Rules for the credit

Ø  No absence in the seminars (exception max 2 absences in illness)

Ø  In case of missing in the class →

o   Missing on illness – paper from the physician

o   The compensation of an absence – seminar work

Ø  Late arrival at seminars (5 or more minutes late) means extra seminar work.

Ø  Everybody must submit the Seminar Work in the PowerPoint presentation including speech presentation on practical classes (every student will choose the topic for the presentation from the list of topics)

Ø  PowerPoint presentation must be 8-10 minutes long, it must not be read from any paper or notes.

Ø  If student cannot present the presentation (in case of illness or any other reason), he/she must choose another topic from the list and do the presentation in another seminar.


Rules for the exam

Ø  Obtaining the credit is necessary in order to pass the exam

Ø  Oral exam only

Ø  Registration for exam possible only via SIS system

Ø  Student will choose 2 questions from the list of questions for Pathological Physiology (available in Study materials)

Ø  Teachers might ask additional questions from different areas of Pathological physiology

Ø  All chosen and asked question are equal with respect to validity of exam and exam results (exam mark)

Literature - Czech
Last update: prof. PharmDr. Petr Nachtigal, Ph.D. (30.09.2021)


  • Huether, Sue E. McCane, Kathryn L. (eds.). Understanding pathophysiology. Saint Louis: Mosby, 2000, 1196 s. ISBN 0-323-00791-0.
  • Kaufman, Christian E. McKee, Patrick A. (eds.). Essentials of pathophysiology. Boston : Philadelphia: Little, Brown and company ; Lippincott Williams & Wilkins, , 799 s. ISBN 0-316-48405-9.

Syllabus -
Last update: prof. PharmDr. Petr Nachtigal, Ph.D. (29.09.2021)
  • Necrosis, pathophysiology, types of necrosis
  • Atrophy, pathophysiology, types of atrophy
  • Dystrophy, pathophysiology, types of dystrophy
  • Thrombosis, pathophysiology, types of thrombi
  • Pathophysiology of edema, embolism, metastasis, pathophysiology
  • Hyperemia, ischemia, hemorrhage, pathophysiology
  • Tumors, terminology, benign and malignant tumors
  • Anemia, causation of anemia
  • Leukopenia and leukocytosis
  • Leukemias, pathophysiology, types of leukemia
  • Inflammation, microscopic manifestation of inflammation, mediators of inflammation
  • Disorders of the primary hemostasis
  • Disorders of hemocoagulation
  • Ischemic heart disease, causation, angina pectoris, myocardial infarction
  • Arterial Hypertension, pathophysiology, pathophysiology
  • Pulmonary hypertension, Cor Pulmonale
  • Arrhythmia, pathophysiology, types of arrhythmia
  • Cardiac failure, pathophysiology, clinical manifestation
  • Atherosclerosis, risk factors, pathophysiology, clinical manifestation
  • Dyspepsia of stomach and gut
  • Acute gastritis, pathophysiology
  • Peptic ulcer disease, gastric ulcer, duodenal ulcer, pathophysiology
  • Colorectal cancer
  • Crohn´s disease, pathophysiology, pathophysiology
  • Ulcerative colitis
  • Pancreatitis, pathophysiology, pathophysiology
  • Liver insufficiency, consequences of the liver insufficiency
  • Acute and chronic bronchitis, pathophysiology
  • Emphysema and bronchiectasis
  • Asthma, pathophysiology, pathophysiology, clinical manifestation
  • Respiratory failure, pathophysiology, clinical manifestation
  • Lung cancer
  • Glomerulonephritis, pathophysiology, pathophysiology, clinical manifestation
  • Nephrotic/nephritic syndrome, pathophysiology
  • Acute renal failure, causation, clinical manifestation
  • Chronic renal failure, causation, clinical manifestation
  • Diabetes mellitus, types, acute and chronic clinical manifestation
  • Metabolic syndrome, characterization, clinical manifestation
  • Alteration of hypothalamic – pituitary system
  • Alteration of thyroid gland – hyperthyroidism, hypothyroidism
  • Addison disease, pathophysiology, clinical manifestation
  • Hyperaldosteronism (Conn Syndrome), pathophysiology, clinical manifestation, Pheochromocytoma, pathophysiology, clinical manifestation
  • Cushing syndrome, pathophysiology, clinical manifestation
  • Alterations of water metabolism, dehydratation, hyperhydration
  • Alterations of ions balance, sodium, potassium
  • Acidosis, pathophysiology, types of acidosis, compensation, clinical manifestation
  • Alkalosis, pathophysiology, types of alkalosis, compensation, clinical manifestation
  • Osteoporosis, osteomalacia, clinical manifestation
  • Fracture, bursitis, dislocation
  • Osteoarthrosis, rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute rheumatic fever
  • Low back pain
  • Gout
  • Systemic lupus erythematosus, pathophysiology, clinical complication
  • Amenorrhoea and dysmenorhea, pathophysiology
  • Cervical and brest cancers
  • Infertility
  • Preeclampsia
  • Prostatic disorders
  • Anorexia Nervosa
  • Anxiety Disorders, pathophysiology, clinical manifestation
  • Depression, pathophysiology, clinical manifestation
  • Bipolar affective disorder
  • Schizofrenia, pathophysiology, clinical manifestation
  • Multiple sclerosis, pathophysiology, clinical manifestation
  • Epilepsy, pathophysiology, clinical manifestation
  • Parkinson’s disease, pathophysiology, clinical manifestation


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