Clinical Immunology - B80033 (General Medicine - English parallel)
Title: Clinical Immunology
Guaranteed by: Institute of Immunology and Microbiology First Faculty of Medicine and General University Hospital in Prague (11-00351)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/25, C+Ex [HS]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: MUDr. Mgr. Jitka Petanová, CSc.,
Old code: 33
Guarantor: MUDr. Mgr. Jitka Petanová, CSc.
Comes under: Compulsory for GM 4.y._23/24
Attributes: Lékařství
Klinický předmět
Pre-requisite : {Prerekvizity pro zápis Mikrobiologie 2 pro ALEK}, B83161, B83162
Co-requisite : B80054, B83163
Is pre-requisite for: B81053
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download Immunodeficiency II.pdf Immunodeficiency. second part MUDr. Dana Čechová
Annotation -
Lectures and seminars in one-week block oriented to the summary of basic immunological knowledge, immunopathologic reactions and application of immunopathological mechanisms into different organs and systems. Differential diagnosis of immunopathological states, their laboratory tests and treatment.
Last update: Petanová Jitka, MUDr. Mgr., CSc. (06.09.2019)
Aim of the course

The application of basic immunology mechanisms and components in the clinical immunology and allergology, differential diagnostics and therapy.

Last update: Petanová Jitka, MUDr. Mgr., CSc. (06.09.2019)
Syllabus -

The structure, mechanisms and function of the immune system. Immunopathologic reactions, inflammation, basic immunologic diagnoses (immunodeficiency, autoimmune diseases, allergy), transplantations. Clinical microbiology in association to immune dysfunctions. Diagnostic process, laboratory tests, treatment.

Last update: Petanová Jitka, MUDr. Mgr., CSc. (06.09.2019)
Literature -

Chapel, H. et al.: Essentials of Clinical Immunology. Blackwell Publishing, 2006 and new editions.
Playfair, Chain: Immunology at a Glance. Blackwell Publ., 2005
Nairn, Roderick, Helbert, Matthew: Immunology for Medical Students. ELSEVIER HEALTH SCIENCES, 2007.

Last update: Petanová Jitka, MUDr. Mgr., CSc. (22.09.2022)
Teaching methods
Presence form of education Lectures and seminars in terms of study schedules (schema in SIS). Similar scheme in all weeks of blocks.  Update and aditional informations for each group are in MS TEAMS or sent by e-mail Teachers and topics: Černý - basic immunology, Čechová - immunodeficiency, Posová - autoimmunity, Adámková - clinical microbiology, Čechová or Petanová - allergology. Individual consultations on request (by e-mail).
Last update: Petanová Jitka, MUDr. Mgr., CSc. (22.09.2023)
Entry requirements

Credit from Basic Immunology. Prerequisities.

Last update: Petanová Jitka, MUDr. Mgr., CSc. (02.09.2021)
Registration requirements


Last update: Petanová Jitka, MUDr. Mgr., CSc. (02.09.2021)
Course completion requirements

Credit: presence form of education: activity during seminars, presence min. 90%.

Examination: oral in person, 3 questions

Last update: Petanová Jitka, MUDr. Mgr., CSc. (22.09.2023)
Requirements to the exam -

Examination: oral (in person), 3 questions (1 question from topic I, 2 questions from topic II). Terms of examination: week after the block, exam. period (January, February, June).


Examination topics:

I. Basic imunology

1.                     Basic characteristic of the innate immunity

2.                     Effector cells of the innate immunity

3.                     Humoral components of the innate immunity

4.                     Phagocytosis

5.                     Natural killer cells

6.                     Dendritic cells and their importance (+ clinical use)

7.                     Cytokines - basic characteristic. Functional groups, examples

8.                     Proinflammatory cytokines (+ clinical importance and use)

9.                     Complement system

10.                   Basic characteristic of the adaptive immunity

11.                   Antigen presenting cells

12.                   Recognition of the antigen by T cells and by B cells - the difference

13.                   Activation of B lymphocytes and T lymphocytes

14.                   Specific cytotoxic reaction

15.                   Immunoglobulins. Functions of antibodies             

16.                   Interaction between cells

17.                   Mucosal immunity (structure and function); oral tolerance

18.                   Inflammation (inflammatory reaction, compounds, phases)

19.                   Immunological tolerance (central, peripheral)

20.                   Hypersensitivity reaction type I

21.                   Hypersensitivity reaction type II

22.                   Hypersensitivity reaction type III

23.                   Hypersensitivity reaction type IV

24.                   Antireceptor antibodies

25.                   Transplantation, graft rejection and its prevention.

26.                   Transplantation, graft versus host reaction

27.                   Defence to extracellular and intracellular pathogens - comparison


II. Clinical immunology and allergology (pathogenesis, clinical signs, examples of diseases, basic diagnostic and therapeutic possibilities)

1.      Antitumor immunity, therapy

2.      Clinical and laboratory signs of inflammation

3.      Chronic inflammation and its complications

4.      Primary antibody immunodeficiency

5.      Primary cellular immunodeficiency

6.      Complement dysfunctions

7.      Phagocytic dysfunctions

8.      Secondary immunodeficiency

9.      Diagnostics of immunodeficiency (clinical, laboratory methods)

10.  Organ specific autoimmune diseases - basic characteristic, examples

11.  Systemic autoimmune diseases - basic characteristic, examples

12.  Systemic lupus erythematosus

13.  Sjogren´s syndrome

14.  Antiphospholipid syndrome

15.  Vasculitis - basic classification, clinical symptoms

16.  Laboratory tests for diagnostic of autoimmune diseases

17.  Anaphylactic and anaphylactoid reaction, treatment

18.  Allergic rhinoconjunctivitis - pathogenesis, symptoms, treatment

19.  Allergy and bronchial asthma

20.  Food allergy, food intolerance

21.  Drug allergy

22.  Diagnostic of allergic diseases

23.  Immunomodulation

24.  Therapeutic use of immunoglobulins

25.  Monoclonal antibodies and their use (in diagnostic and therapy)

26.  Groups of immunosuppressive drugs

27.  Therapy of allergic diseases

28.  Passive and active immunization, adjuvants

29.  Immunopathologic states in haematology

30.  Immunopathologic states in neurology

31.  Immunopathologic states in respiratory system

32.  Immunopathologic states in otorhinolaryngology

33.  Immunopathologic states in gastroenterology

34.  Immunopathologic states in dermatology

35.  Immunopathologic states in nephrology

36.  Immunopathologic states in reproduction

Last update: Petanová Jitka, MUDr. Mgr., CSc. (22.09.2023)
Education plan -
Schedule block
Week of the block Day From - To Education type Theme Teacher Files Note Hodnocení
1Monday08:00 - 12:00lecture+seminarIntroduction. Structure of lectures and seminars. Terminology. Innate immunity, adaptive immunity, prezentation of antigens. Antiinfectious immunity, inflammation, regulation of the immune system, mucosal IS, the tolerance. Immunooncology, transplantations.RNDr. MUDr. Viktor Černý, Ph.D.Institute of Hygiene and Epidemiology, Praktikum I or Praktikum II
průměr: 3, hodnoceno: 11x
Tuesday08:30 - 12:00lecture+seminarImmunodeficiencyMUDr. Dana Čechová 
průměr: 3, hodnoceno: 6x
Wednesday08:30 - 12:00lecture+seminarImmunopathologic states. Autoimmunity.MUDr. Helena Posová, CSc. 
průměr: 3, hodnoceno: 4x
Thursday08:30 - 12:00lecture+seminarAllergy. Allergic diseases and their treatment.MUDr. Mgr. Jitka Petanová, CSc. 
průměr: 3, hodnoceno: 5x
Friday08:30 - 10:00lecture+seminarClinical microbiology and immunopathological statesdr. Adámková / dr. Hintnausová
průměr: 3, hodnoceno: 4x
10:00 - 12:00lecture+seminarImmunopathologic states, differential diagnoses, acces to a patient. Credit.dr. Čechová / dr. Petanová / dr. Posová
průměr: 4, hodnoceno: 4x