New Synthetic Methods - MC270P85
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Poslední úprava: Dr. Michael Janus Bojdys (13.02.2015)
This course aims to add to your range and understanding of important chemical reactions used in modern synthetic chemistry, with an emphasis on how they can control the stereochemistry, regioselectivity and chemoselectivity. The course begins by looking at pericyclic reactions and the organic chemistry of some p-block elements and then moves on to the use of organometallics in synthesis. Topics: - Pericyclic reactions and the Woodward-Hoffmann rules: why are pericyclic reactions selective? - The use of p-block elements in organic synthesis - Organometallics in synthesis. Reactivity and selectivity of organometallic reagents and how this is related to structure and mechanism. The chemistry of various transition metals will be discussed. - Topics will include, Ru, Mo, and Ti alkylidene carbene compounds for metathesis; Pd in organic synthesis, the Heck, Suzuki, Stille and Sonogashira cross-coupling reactions and the formation of carbon-heteroatom bonds mediated by Pd; other transition metals. Recommended books: Frontier orbitals and organic chemical reactions. Fleming, I, Wiley, 1976 Pericyclic Reactions, Fleming, I., Oxford Chemistry Primer 67, OUP, 1998 Principles and applications of organotransition metal chemistry (2nd ed), Collman, J.P., Hegedus, L.S., Mill Valley, 1987 Organic Chemistry, Clayden, Greeves, Warren and Wothers, OUP, 2001, Chapter 48. |