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Poslední úprava: doc. RNDr. František Půta, CSc. (07.02.2018)
The lecture course is devoted to the questions of "life and death" but just at the cellular level. Apoptosis or programmed cell death is being the most natural and common mode of elimination of the eukaryotic cells. Individual lectures are focused both on the significance of apoptosis (or more generally cell death) in embryogenesis and postnatal life of a multicellular organism, and on mechanism and regulation of this essential cellular process in selected model organisms. Last but not least, pathological consequences of disregulated apoptosis will be discussed as well.Altogether nine approx. 1.5 - 2 hrs lasting lectures + preparation of review of cell death-related article. Exam: written test, possible also follow-up oral exam; preparation and submission of review/evaluation of a cell death-related article (from blind selection) is required for the written test. |
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Poslední úprava: doc. RNDr. František Půta, CSc. (07.02.2018)
Powerpoint presentation of the lectures (http://www.img.cas.cz/csa/prednasky/). Recent books focused on apoptosis - for example "Means to an end" Douglas R. Green, CSH Press, 2011, or "Apoptosis - Physiology and Pathology" Edited by JC Reed, DR Green, Cambridge University Press, 2011 |
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Poslední úprava: doc. RNDr. František Půta, CSc. (07.02.2018)
Zkouška je písemná, případně je možné i následné ústní přezkoušení. Písemná zkouška se skládá se dvou bloků - kvizový blok 15-20 otázek (A-D možnosti, 0-4 správné odpovědi) a odpovědi na krátké otázky (10-15 otázek). Pro úspěšné absolvování zkoušky (známka 1-3) je nezbytné dosáhnout alespoň 70% maximálního bodového ohodnocení. Není žádný časový limit. |
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Poslední úprava: doc. RNDr. František Půta, CSc. (07.02.2018)
1. Basic definitions of apoptosis/programmed cell death, history and evolution of cell death. Principles and overview of signaling pathways in apoptosis, comparison of various forms of cell death. 2. Caspases and other proteases: initiators and effectors of apoptotic signaling. 3. Mitochondria and other organelles in apoptosis; proteins from the Bcl-2 family. 4. Intrinsic induction of apoptosis; tumor suppressor protein p53. 5. Extrinsic induction of apoptosis. 6. Alternative ways to die: autophagy, necrosis etc. 7. Final destruction of apoptotic cell and removing the corpses. 8. Cell death in invertebrates, plants and unicellular organisms. 9. Patophysiology of cell death and methodology of its detection and quantification. |