PředmětyPředměty(verze: 945)
Předmět, akademický rok 2019/2020
   Přihlásit přes CAS
Pathology - DA0105439
Anglický název: Pathology
Zajišťuje: Ústav patologie a molekulární medicíny (13-321)
Fakulta: 2. lékařská fakulta
Platnost: od 2019 do 2020
Semestr: zimní
Body: 12
E-Kredity: 12
Způsob provedení zkoušky: zimní s.:
letní s.:
Rozsah, examinace: zimní s.:3/4, Z [HT]
letní s.:4/5, Z+Zk [HT]
Rozsah za akademický rok: 28 [týdny]
Počet míst: zimní:neomezen / neomezen (neurčen)
letní:neomezen / neomezen (neurčen)
Minimální obsazenost: neomezen
4EU+: ne
Virtuální mobilita / počet míst pro virtuální mobilitu: ne
Kompetence:  
Stav předmětu: vyučován
Jazyk výuky: angličtina
Způsob výuky: prezenční
Způsob výuky: prezenční
Úroveň:  
Garant: prof. MUDr. Roman Kodet, CSc.
Kategorizace předmětu: Lékařství > Teoretické předměty
Prerekvizity : DA01010332, DA0101332, DA0101337, DA0101438, DA0103040, DA0103337, DA0103446, DA0104339
Je korekvizitou pro: DA0105454
Je prerekvizitou pro: DA0108060, DA0108369, DA0110308, DA0110016, DA0110608, DA0108006, DA0108358, DA0108370, DA0110018, DA0108325, DA0108390, DA0108004
Termíny zkoušek   Rozvrh   Nástěnka   
Podmínky zakončení předmětu - angličtina
Poslední úprava: Petra Poděbradská (21.09.2022)

Credits

Credits for winter semester:

Students are expected to obtain credit at the end of each term. The conditions for the credit are as follows:

Attendance

Maximally 2 absences are tolerated in each term if there is an appropriate reason stated by the student - those absentees leaving out more than 2 courses will have to pass an extended (examined) individual credit before the end of a term.

Activity index (optional)

The knowledge from the semester is going to be regularly monitored via virtual platform Kahoot! Such a feature allows teachers to test the students through quiz questions, which should be answered online by students during the very training itself, using their electronic devices. The questions are going to be regarded to the topics from previous lectures and seminars. The platform consequently allows statistically analyzing and saving answers from each student individually. To obtain the credit, each student has to reach at least 60% of correct answers at average at the end of semester. The aim of testing the students is to encourage continuous studying and to give you feed-back about the range of your knowledge of pathology. However, this system of activity index is fully optional. Students, who cannot or do not want to participate in Kahoot! testing for any reason, are going to be examined at the end of the semester from all discussed topics instead.

Credit examination

In case the student does not obtain 60 % in the activity index and/or leaves more than 2 courses, he/she will be examined by the head of the department (or substitute teacher) from any topics discussed during the whole semester. The exam will be held during the last week of the semester – the exact date is going to be updated during the semester. If the student fails the exam, he/she won’t be given the credit.

There is no other way to obtain credit for the winter semester.

Credits for summer semester:

Students are expected to obtain credit at the end of each term. The conditions for the credit are as follows:

Attendance

The rules are similar as during the winter semester - maximally 2 absences are tolerated in each term if there is an appropriate reason stated by the student - those absentees leaving out more than 2 courses will have to pass an extended (examined) individual credit before the end of a term.

Activity index (optional)

The rules are the same as during the winter semester.

Created: 23. 9. 2021 / Modified: 20. 9. 2022 / Responsible person: MUDr. Jan Balko

Literatura - angličtina
Poslední úprava: Petra Poděbradská (01.10.2021)

Recommended literature:

KUMAR. V, ed. Robbins Basic Pathology, 10th Edition: Saunders, Philadelphia, 2017. ISBN 9780323353175.

LEVISON, D.A., ed, Muir's Textbook of Pathology, 16th Edition“: CRC Press, 2020. ISBN 9780367146726.

Požadavky ke zkoušce - angličtina
Poslední úprava: Petra Poděbradská (21.09.2022)

Exam

Final examination:

Only students with both credits may enlist for the final examination. The exam itself consists of 2 parts:

Practical part

  • microscopic pathology (reading and interpreting of 2 histological slides; time – on the examination day)

Theoretical part

  • divided into 3 topics covering general as well as organ pathology.

Failure of any part of the exams automatically leads to the failure of the whole exam.

Students, who fail to pass the examination in the given academic year, will have to repeat the whole subject including attendance to compulsory classes. Those students will also have to fulfill conditions for a credit in both semesters again. In such cases, the credit given in the previous winter and/or summer semester won't be accepted.

 
Rozpis rozvrhový
Rozvrhový lístek Datum Od - Do Typ výuky Téma Učitel Soubory Poznámka
19aDA0105439p1

Okruhy studentů
M3.AVSEOB
Čt 03.10.2019 10:45 - 13:20 přednáška

1. Anatomical pathology as a specialty: from historical aspects to what pathology brings to contemporary medicine: autopsy, surgical speciments, biopsy, frozen section diagnosis its importance and  risks.

2. Laboratory methods utilized by anatomic pathology:

a) classical staining methods - HE, PAS, trichrome, imppregnations, elastic fibers;

b) histochemistry - significance, basic reactions - non-specific esterase, chloroacetate-esterase, phosphatases

c) immunohistochemistry and in situ hybridization - principles, practical usage in diagnostic process

d) electron mocroscopy - its usefulness and limitations

3. Cell injury:

a) definition, causes

b) mechanisms - hypoxic and ischemic - free radicals

c) cell death - apoptosis versus necrosis

d) gangrene

prof. MUDr. Roman Kodet, CSc.
Čt 10.10.2019 10:45 - 13:20 přednáška

1. Disorders of the vacular flow:

a) underlying causes - diseases of the heart and of the vessels

b) venostasis acute, chronic

c) pathology of shock

d) hypertension - classification, pathology, complications

2. Hemorrhagic diathesis:

a) types of hemorrhage

b) thrombocytopenia

c) coagulative disorders, hereditary, DIC

d) vascular causes

prof. MUDr. Roman Kodet, CSc.
Čt 17.10.2019 10:45 - 13:20 přednáška

Metabolic disorders of lipids, proteins and corbohydrates.

Intracellular accumulations:

a) steatosis, classification, forms, development inborn errors of lipid metabolism - Gaucher´s disease, Nieman - Pick´s disease, Tay- Sachs´ disease

b) pathology of the interstitial matrix - acquired ) aging, myxedema), congenital (cystic medionectosis) and inborn errors of metabolism of proteoglycans ( mucopolysacharidoses)

c) glycogen storage diseases - acquired, inherited ( von Gierke,Pompe)

 

 

 

 

prof. MUDr. Josef Zámečník, Ph.D.
Čt 24.10.2019 10:45 - 13:20 přednáška

Pigments and pathology of their distribution:

a) autogenous - melanin, lipofuscin, ceroid, lipochrome;

b) hematogenous - hemosiderin, hematoidin, hemoglobin, hematin; pathology of icterus

c) exogenous - how the pigments get into the organism- pneumoconiosis ( anthracosis, silicosis, siderosis, asbestosis, berylliosis), sequelae of complicated pneumoconiosis

prof. MUDr. Josef Zámečník, Ph.D.
Čt 31.10.2019 10:45 - 13:20 přednáška

Inflammation I. Non-specific inflammation:

a) definition of inflammation, clinical and pathologic features - local, general

b) exudation of inflammatory cells, chemotaxis, mediators

c) acute inflammation versus chronic inflammation

d) types of exudative inflammation ( serous, suppurative, lymphocytis, fibrinous, gangrenous, progression, healing, complications

prof. MUDr. Roman Kodet, CSc.
Čt 07.11.2019 10:45 - 13:20 přednáška

Inflammation II. Specific, granulomatous inflammation:

a) definition, morphology, pathogenesis

b) tuberculosis - development, progression, healing

c) syphilis, leprosy

d) non-caseating granulomas with a suppurative component (cat scratch disease, tularemia, brucellosis etc.)

prof. MUDr. Roman Kodet, CSc.
Čt 14.11.2019 10:45 - 13:20 přednáška

Pathology of diseases of the immunity.

Pathology of transplantations.

 

 

 

 

 

MUDr. Jan Balko, Ph.D.
Čt 21.11.2019 10:45 - 13:20 přednáška

Morphology of infectious diseases I.

1. General remarks:

a) local spread of infections

b) bacteriemia, sepsis, septicopyemia and its types

c) mechanisms of bacteria-induced injury, bacterial adhesins, toxins

2. Common bacterial diseases:

a) streptococcal and staphylococcal, meningococcal infectionsand their morphology

b) colibacillary infections; salmonellosis; typhus; hemophilus, pseudomonas

 

 

 

 

 

prof. MUDr. Josef Zámečník, Ph.D.
Čt 28.11.2019 10:45 - 13:20 přednáška

Morphology of infectious diseases II.

1. Infections caused by chlamydia, rickettsia and mycoplasma.

2. Mechanism of virus-induced injury.

3. Most common infections caused by viruses - herpes, varicella-zoster, CMV, EBV+ influenza, measles, rubella.

4. Morphology of HIV infection and AIDS.

prof. MUDr. Josef Zámečník, Ph.D.
Čt 05.12.2019 10:45 - 13:20 přednáška

1. Cysts: classification, morphology

2. General oncology I. Oncogenes, supressor genes:

a) activation of oncogenes

-retroviral insertion mutagenesis, experimental cellular transformation

-chromosomal translocations

-amplification

-point mutations

b) supressor genes

-two hit theory, A. Knudson, retinoblastoma+-other supressor genes - p53, WT1

c) products of oncogenes, signal transduction pathways, regulatory of cell kinetics  

prof. MUDr. Roman Kodet, CSc.
Čt 12.12.2019 10:45 - 13:20 přednáška

General oncology II.

1. Tumor growth and metastasizing:

a) clonal versus polyclonal tumor development, tumor cell cycle and means of its detection; life span of tumors

b) heterogeneity of tumor cell populations

c) tumor cell invasion

d) development of metastatic spread, homing phenomenon; adhesion moleciles;

2. Incidence of tumors:

a) most frequent malignant tumors in adults, sex-related differences

b) distinction between incidence of tumors in adults and childhood

prof. MUDr. Roman Kodet, CSc.
Čt 19.12.2019 10:45 - 13:20 přednáška

General oncology III. Classification of neoplastic diseases:

1. Epithelial neoplasms and their behavior

a) tumors of surface epithelia ( papilomas; precancerous lesions of the skin, uterine cervix, other; squamous cell carcinoma, basal cell carcinoma);

b) neoplasm of the glandular and organ origin ( adenomas, adenocarcinomas- gross and microscopic evaluation, biologica, organ examples).

2. Mesenchymal neoplasms, tumors of the peripheral nerves, pigmented nevi and melanoma, teratomas, choriocarcinoma, mesothelioma - general features

prof. MUDr. Roman Kodet, CSc.
Čt 09.01.2020 10:45 - 13:20 přednáška

Pathology of the heart

CREDIT 9.1. 2020 after the lecture - prof. J. Zámečník

prof. MUDr. Roman Kodet, CSc.
Čt 16.01.2020 10:45 - 13:20 přednáška

Pathology of the heart and vessels II.

1/ Myocarditis. Cardiomyopathies

2/ Acquired diseases of the heart valves and their comlications

3/ Pathology of the vessels

prof. MUDr. Roman Kodet, CSc.
19aDA0105439x01

Okruhy studentů
M3.2.AVSEOB
M3.1.AVSEOB
St 02.10.2019 8:00 - 11:30 praktická cvičení

How the courses are organized; biohazard, personal protection

Autopsy demonstrations: Cadaverous changes: physical and chemical, autolysis

MUDr. Jan Soukup
St 09.10.2019 8:00 - 11:30 praktická cvičení Gross and microscopic specimens: necrosis, gangrene, atrophy MUDr. Vít Campr
St 16.10.2019 8:00 - 11:30 praktická cvičení

Gross and microscopic pathology:

a) disorders of the vascular flow in general

b) trombosis, embolism

MUDr. Jan Balko, Ph.D.
St 23.10.2019 8:00 - 11:30 praktická cvičení Metabolic disorders ( steatosis, amyloidosis) MUDr. Jan Soukup
St 30.10.2019 8:00 - 11:30 praktická cvičení

a) calcification - dystrophic - metastatic

b) stones, their occurrence ( gallbladder, urinary bladder, salivary glands, pancreas), pathogenesis, composition, principles of complications

c) pathology of the pigments

MUDr. Petr Škapa, Ph.D.
St 06.11.2019 8:00 - 11:30 praktická cvičení

a/ calcification - dystrophic

                     - matastatic

b/ stones, their occurrence

c/ pathology of the pigments

MUDr. Jan Soukup
St 13.11.2019 8:00 - 11:30 praktická cvičení non-specific inflammation tuberculosis and other inflammatory granulomatous diseases MUDr. Jan Soukup
St 20.11.2019 8:00 - 11:30 praktická cvičení

Inflammation, non specific and specific types - repetion;

infectious diseases

MUDr. Vít Campr
St 27.11.2019 8:00 - 11:30 praktická cvičení

a) infectious diseases

b) transpantation

c) regeneration, hypertrophy, hyperplasia

prof. MUDr. Josef Zámečník, Ph.D.
St 04.12.2019 8:00 - 11:30 praktická cvičení

a/ autoimmune and autoinflammatory diseases

b/ transplantations

MUDr. Jan Balko, Ph.D.
St 11.12.2019 8:00 - 11:30 praktická cvičení Cysts MUDr. Vít Campr
St 18.12.2019 8:00 - 11:30 praktická cvičení Epithelial, mesenchymal and germ cell tumors, other neoplasm. MUDr. Petr Škapa, Ph.D.
St 08.01.2020 8:00 - 11:30 praktická cvičení cysts and neoplastic diseases repetition MUDr. Linda Čapková, Ph.D.
19aDA0105439x02

Okruhy studentů
M3.4.AVSEOB
M3.3.AVSEOB
St 02.10.2019 8:00 - 11:30 praktická cvičení

How the courses are organized; biohazard, personal protection

Autopsy demonstrations: Cadaverous changes: physical and chemical, autolysis

MUDr. Marek Grega
St 09.10.2019 8:00 - 11:30 praktická cvičení Gross and microscopic specimens: necrosis, gangrene, atrophy MUDr. Linda Čapková, Ph.D.
St 16.10.2019 8:00 - 11:30 praktická cvičení

Gross and microscopic pathology:

a) disorders of the vascular flow in general

b) trombosis, embolism

MUDr. Zuzana Prouzová
St 23.10.2019 8:00 - 11:30 praktická cvičení Metabolic disorders ( steatosis, amyloidosis) MUDr. Linda Čapková, Ph.D.
St 30.10.2019 8:00 - 11:30 praktická cvičení Pathology of the pigments. Repetition. MUDr. Jaromír Háček
St 06.11.2019 8:00 - 11:30 praktická cvičení

a) calcification - dystrophic - metastatic

b) stones, their occurrence ( gallbladder, urinary bladder, salivary glands, pancreas), pathogenesis, composition, principles of complications

c) pathology of the pigments

MUDr. Zuzana Prouzová
St 13.11.2019 8:00 - 11:30 praktická cvičení Tuberculosis and other inflammatory granulomatous diseases MUDr. Jaromír Háček
St 20.11.2019 8:00 - 11:30 praktická cvičení

Inflammation, non specific and specific types - repetion;

infectious diseases

MUDr. Petr Škapa, Ph.D.
St 27.11.2019 8:00 - 11:30 praktická cvičení

a) infectious diseases

b) transpantation

c) regeneration, hypertrophy, hyperplasia

MUDr. Marek Grega
St 04.12.2019 8:00 - 11:30 praktická cvičení

a/ autoimmune and autoinflammatory diseases

b/ transplantations

MUDr. Jaromír Háček
St 11.12.2019 8:00 - 11:30 praktická cvičení Cysts MUDr. Zuzana Prouzová
St 18.12.2019 8:00 - 11:30 praktická cvičení Epithelial, mesenchymal and germ cell tumors, other neoplasms. MUDr. Jan Balko, Ph.D.
St 08.01.2020 8:00 - 11:30 praktická cvičení cysts and neoplastic diseases repetition MUDr. Marek Grega
 
Rozpis rozvrhový
Rozvrhový lístek Datum Od - Do Typ výuky Téma Učitel Soubory Poznámka
19bDA0105439p1

Okruhy studentů
M3.AVSEOB
Čt 20.02.2020 8:00 - 11:30 přednáška

Pathology of the blood:

1. anemias

a) posthemorrhagic

b) of the increased erythrocyte degradation and decreased erythrocyte life span

c) failure of maturation / megaloblastic anemias

d) bone marrow failure - aplastic anemias

White blood cell disorders

Reactive conditions: leucocytosis, leukopenia // infectious mononucleosis

Myelodysplastic and myeloproliferative diseases: classification

prof. MUDr. Roman Kodet, CSc.
Čt 27.02.2020 8:00 - 11:30 přednáška

Pathology of the lymph nodes and lymphomas reactive changes //inflammation// non-Hodgkin´s malignant lymphomas

Plasma cell disorders

MUDr. Jan Soukup
Čt 05.03.2020 8:00 - 11:30 přednáška

Pathology of the respiratory system I

Obstructive lung diseases

Restrictive lung diseases

prof. MUDr. Roman Kodet, CSc.
Čt 12.03.2020 8:00 - 11:30 přednáška

Pathology of the respiratory system II

Pulmonary infections

Lung tumors

MUDr. Linda Čapková, Ph.D.
Čt 19.03.2020 8:00 - 11:30 přednáška Pathology of the GIT II prof. MUDr. Roman Kodet, CSc.
Čt 26.03.2020 8:00 - 11:30 přednáška

Pathology of the GIT I

Oral cavity

Oesophagus

Stomach

MUDr. Jan Soukup
Čt 02.04.2020 8:00 - 11:30 přednáška Pathology of the female genital system I MUDr. Petr Škapa, Ph.D.
Čt 09.04.2020 8:00 - 11:30 přednáška Pathology of the kidneys MUDr. Jaromír Háček
Čt 16.04.2020 8:00 - 11:30 přednáška Pathology of the female genital system II. MUDr. Petr Škapa, Ph.D.
Čt 23.04.2020 8:00 - 11:30 přednáška Pathology of the brain I. prof. MUDr. Josef Zámečník, Ph.D.
Čt 30.04.2020 8:00 - 11:30 přednáška Pathology of the brain II prof. MUDr. Josef Zámečník, Ph.D.
Čt 07.05.2020 8:00 - 11:30 přednáška Pathology of the liver prof. MUDr. Roman Kodet, CSc.
Čt 14.05.2020 8:00 - 11:30 přednáška

Pathology of the bones and joints

Metabolic diseases-osteoporosis

Fibrous dysplasia

Bone tumors

prof. MUDr. Roman Kodet, CSc.
Čt 21.05.2020 8:00 - 11:30 přednáška

Pathology of the endocrine system

Diabetes mellitus

Pituiary gland, tumors, basic syndromes

Multiple endocrine neoplasia

prof. MUDr. Roman Kodet, CSc.
19bDA0105439x01

Okruhy studentů
M3.2.AVSEOB
M3.1.AVSEOB
St 19.02.2020 8:00 - 12:25 praktická cvičení Pathology of the heart MUDr. Jan Balko, Ph.D.
St 26.02.2020 8:00 - 12:25 praktická cvičení Anemias // leukemias// recap. cardiovascular pathology MUDr. Jan Soukup
St 04.03.2020 8:00 - 12:25 praktická cvičení Pathology of the hemopoetic system. Pathology of the lymph nodes MUDr. Jan Balko, Ph.D.
St 11.03.2020 8:00 - 12:25 praktická cvičení Pathology of the lungs MUDr. Jan Soukup
St 18.03.2020 8:00 - 12:25 praktická cvičení Recap. pathology of the lungs MUDr. Linda Čapková, Ph.D.
St 25.03.2020 8:00 - 12:25 praktická cvičení Pathology of the oesophagus and stomach MUDr. Vít Campr
St 01.04.2020 8:00 - 12:25 praktická cvičení Pathology of the GIT MUDr. Jan Soukup
St 08.04.2020 8:00 - 12:25 praktická cvičení Pathololgy ofthe small and large bowel - inflammation, neoplasms. Pathology of the biliary tee. MUDr. Jan Balko, Ph.D.
St 15.04.2020 8:00 - 12:25 praktická cvičení Pathology of the kidneys MUDr. Jan Balko, Ph.D.
St 22.04.2020 8:00 - 12:25 praktická cvičení Pathology of the female genital system and breast MUDr. Zuzana Prouzová
St 29.04.2020 8:00 - 12:25 praktická cvičení Pathology of the female and male genital tract MUDr. Jan Soukup
St 06.05.2020 8:00 - 12:25 praktická cvičení Pathology of the brain - Rector's day MUDr. Petr Škapa, Ph.D.
St 13.05.2020 8:00 - 12:25 praktická cvičení Pathology of the central nervous system MUDr. Vít Campr
St 20.05.2020 8:00 - 12:25 praktická cvičení Pathology of the bones and joints MUDr. Vít Campr
19bDA0105439x02

Okruhy studentů
M3.3.AVSEOB
M3.4.AVSEOB
St 19.02.2020 8:00 - 12:25 praktická cvičení Pathology of the heart MUDr. Jaromír Háček
St 26.02.2020 8:00 - 12:25 praktická cvičení Anemias // leukemias// MUDr. Petr Škapa, Ph.D.
St 04.03.2020 8:00 - 12:25 praktická cvičení Pathology of the hemopoetic system. Pathology of the lymph nodes MUDr. Marek Grega
St 11.03.2020 8:00 - 12:25 praktická cvičení Pathology of the lungs MUDr. Vít Campr
St 18.03.2020 8:00 - 12:25 praktická cvičení Recap. pathology of the lungs MUDr. Marek Grega
St 25.03.2020 8:00 - 12:25 praktická cvičení Pathology of the oesophagus and stomach MUDr. Jaromír Háček
St 01.04.2020 8:00 - 12:25 praktická cvičení Pathology of the GIT MUDr. Zuzana Prouzová
St 08.04.2020 8:00 - 12:25 praktická cvičení Pathology of the small and large bowel - inflammation MUDr. Petr Škapa, Ph.D.
St 15.04.2020 8:00 - 12:25 praktická cvičení Pathology of the kidneys MUDr. Jaromír Háček
St 22.04.2020 8:00 - 12:25 praktická cvičení Pathology of the female genital system and breast MUDr. Linda Čapková, Ph.D.
St 29.04.2020 8:00 - 12:25 praktická cvičení Pathology of the female and male genital tract MUDr. Jan Balko, Ph.D.
St 06.05.2020 8:00 - 12:25 praktická cvičení Pathology of the brain - Rector's day MUDr. Zuzana Prouzová
St 13.05.2020 8:00 - 12:25 praktická cvičení pathology of the central nervous system MUDr. Jaromír Háček
St 20.05.2020 8:00 - 12:25 praktická cvičení Pathology of the bones and joints MUDr. Jaromír Háček
 
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