Subjects

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Malignancies of B and T lymphocytes - CPVL022

Title:	Maligní onemocnění B a T lymfocytů
Guaranteed by:	Department of Immunology and Clinical Biochemistry 3FM CU (12-IMUN)
Faculty:	Third Faculty of Medicine
Actual:	from 2024
Semester:	summer
Points:	2
E-Credits:	2
Examination process:	summer s.:
Hours per week, examination:	summer s.:0/30, C [HS]
Extent per academic year:	30 [hours]
Capacity:	unknown / unknown (10)
Min. number of students:	1
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	not taught
Language:	Czech
Teaching methods:	full-time
Level:
Note:	course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. MUDr. Jan Novák, Dr.
Pre-requisite :	C1VL001

Examination dates Schedule

Annotation -

Compulsory elective course. The course describes the classification, pathophysiology, clinical features prognosis and principles of the treatment of the most common malignancies of B and T cells - leukemia and lymphomas. In the theoretical part (seminars) students will learn the classification and pathophysiology, the clinical features will be demonstrated on the patients of OKH FNKV. An important part of the course represents the demonstration of the immune pathologies often accompanying lymphomas and leukemia - autoimmune syndromes such as autoimmune hemolytic anemia or immunodeficiencies. The immunotherapy changed the the prognosis of many patients suffering from lymphomas and leukemia. Students will get knowledge of the principles and results of immune-based therapies in these settings. The impact of selected original articles on the decision on treatment schedule will be discussed.

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Aim of the course -

To learn the basic classification of the malignancies of B and T cells, to learn their typical clinical features, to learn to estimate their prognosis and treatment modalities.

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Literature -

Medical Immunology. Parslow TG, Stites DP, Terr AI,. - 10th ed. - London: Mc Graw-Hill, 2001.

Essentials of Clinical Immunology, Chapel H, Haeney M et al. Blackwell Science, 4th ed. 1999

Wintrobe's Clinical Hematology, 12th edition

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Teaching methods -

Seminars with active participation of students, practical - patient examination.

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Requirements to the exam -

Presence (75%).

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Syllabus -

1. Classification and pathogenesis of the malignancies of B and T cells

2. Hodgkin?s disease

3. Non-Hodgkin lymphomas

4. Multiple myeloma a monoclonal gamapathies

5. T lymphomas

6. Leukemia

7. Imunodeficiencies, primary a secondary, therapeutic options

8. Autoimmune phenomens in patients suffering the malignancies of B and T cells

9. Immunologic basis of transplantations and immunologic interventions

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)

Entry requirements -

Patophysiology

Last update: Novák Jan, prof. MUDr., Dr. (19.11.2019)