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Basic metabolic pathways (biological oxidation, metabolism of sugars,
lipids, proteins, photosynthesis, citric acid cycle, regulation of
metabolic processes).
Last update: Procházka Marek, prof. RNDr., Ph.D. (30.04.2019)
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Introduction in Biochemistry Last update: GASKOVA/MFF.CUNI.CZ (14.05.2008)
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Oral exam, exam requirements - in the extent of the syllabus. Last update: Gášková Dana, doc. RNDr., CSc. (30.10.2019)
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D.Voet, J.G.Voet: Fundamentals of Biochemistry Life at the molecular LeveL, 5th, Wiley, 2016. D.L.Nelson, M.M.Cox: Lehninger Principles of Biochemistry, 8th, Macmillan Learning, 2021. H.R.Horton, L.A.Moran, K.G.Scrimgeour, M.D. Perry, J.D. Rawn: Principles of Biochemistry, 5th, Pearson Education, Inc., 2011. J.L.Tymoczko, J.M.Berg, L.Stryer: Biochemistry, 9th, W. H. Freeman, 2019. T.M.Devlin: Textbook of Biochemistry with Clinical Correlations, 7th, John Wiley & Sons, 2010.
Last update: Hofbauerová Kateřina, RNDr., Ph.D. (14.12.2023)
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basic course Last update: GASKOVA/MFF.CUNI.CZ (14.05.2008)
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Oral exam requirements are within the scope of the lecture syllabus. Last update: Gášková Dana, doc. RNDr., CSc. (31.10.2019)
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History of biochemistry. Introduction to metabolism: thermodynamics of living systems, metabolic pathways, experimental approaches to metabolic studies, thermodynamics of phosphate compounds, oxidation-reduction reactions.
Saccharide metabolism. Glycolysis:The glycolytic pathway, Glycolytic reactions, Fermentation ? anaerobic pyruvate degradation, Regulation of metabolic flux, Metabolism of other hexoses.
Other pathways of saccharide metabolism. Gluconeogenesis, Glyoxylate pathway, Biosynthesis of oligosaccharides and glycoproteins, Pentose cycle.
Citrate cycle. Overview, Metabolic sources of acetyl-coenzyme A, Citrate cycle enzymes, Citrate cycle regulation, Amphibolic nature of the citrate cycle.
Membrane transport.Transport thermodynamics, Transport kinetics and mechanisms, Primary active transport, Secondary active transport.
Electron transport and oxidative phosphorylation. Mitochondria, Electron transport, Oxidative phosphorylation, Regulation of ATP production.
Photosynthesis. Chloroplasts, Light-dependent reactions, Reactions taking place without direct participation of light.
Expression and transfer of genetic information. Replication: DNA ? the carrier of genetic information, DNA replication: an overview, Replication enzymes. Transcription: Role of RNA in protein synthesis, RNA polymerase, Transcription regulation, Post-transcription modifications. Translation: Genetic code, Transfer RNA, Ribosomes, Translation regulation, Post-translation modifications.
Last update: T_FUUK (24.05.2004)
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