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Course, academic year 2019/2020
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Chronobiology - MB150P95
Title in English: Chronobiology
Czech title: Chronobiologie
Guaranteed by: Department of Physiology (31-152)
Faculty: Faculty of Science
Actual: from 2017
Semester: summer
E-Credits: 3
Examination process: summer s.:oral
Hours per week, examination: summer s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
State of the course: taught
Language: English
Guarantor: doc. PharmDr. Alena Sumová, DSc.
Incompatibility : MB150P16
Is incompatible with: MB150P16
Last update: RNDr. Daniela Horníková, Ph.D. (04.05.2017)
Chronobiology studies temporal rhythmic regulation of biological processes in living organisms, from
gene expression to behavior. The biological rhythms may run with a various periods but the most important are
circadian, i.e. about one day, rhythms which persist even in a non-periodic environment. Circadian rhythms can be
found in most of the organisms known so far, from unicellular prokaryotic to mammals, including humans.
Malfunction of the coordination in the timekeeping system impacts negatively adaptation to external environment,
regulation of physiological functions and health. The lectures may be of interest mostly for bachelor, magister and
doctoral students interested in physiology, zoology, molecular biology and biomedicine.
Requirements to the exam
Last update: RNDr. Daniela Horníková, Ph.D. (09.05.2018)

oral exam/essay

Last update: RNDr. Daniela Horníková, Ph.D. (04.05.2017)

1. Chronobiology as research field, its history and terminology

2. Biological rhythms and their roles in strategies for adaptation and animal survival in external environment

3. Circadian pacemaker and its formal properties

4. Circadian systems and their evolution across species - from procaryotes to humans

5. Genetics of the circadian clocks

6. Mechanisms of circadian regulations of cellular functions

7. Mechanisms of circadian regulations of physiological functions

8. Synchronization of the circadian clock with external environment

9. Melatonin, its role in the body. Melatonin and chronotherapy.

10. Photoperiod and photoperiodic regulation of physiological functions

11. Circadian regulation of sleep, learning and migration

12. Changes of the circadian clocks during the time and significance of the regulation for health

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