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The lectures can be given in english.
The lecture course is mainly focused on the presentation of various mechanisms of activation and modulation of regulated cell death (apoptosis, regulated necrosis, etc.) predominantly in mammalian (mouse and human) cells/organisms and on cell death-related processes. In addition to mammalian cells the mechanisms of regulated cell death will be addressed also in cells of other vertebrates, invertebrates, single cell organisms and plants. Lastly, role or importance of regulated cell death in a number of physiological and pathophysiological processes occurring in organisms is shown and methods of detection and quantification of cell death are presented. Last update: Půta František, doc. RNDr., CSc. (07.02.2018)
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The lectures in Powerpoint are accesible on internet (web address and access will be specified in the first lecture). On the same web address will be also accessible for downloading recent reviews and breakthrough primary paper related to the subject of respective lecture. Last update: Půta František, doc. RNDr., CSc. (07.02.2018)
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The exam is in a written form of test containing a section of quiz questions, then part encompassing short questions and answers and finally two more complex questions dealing with in detail description or assesment of an important mechanism(s) or process(es) in regulated cell death. The maximum number of test points is 72 (out of them max. 30 p. for 15 quiz questions, max. 30 p. for 10 short questions and max. 12 p. for long fundamental questions. To pass the exam (mark 3) is required to obtain at least 40 points. Last update: Anděra Ladislav, RNDr., CSc. (05.06.2019)
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1. Definition of programmed or regulated cell death, its historical and evolution-related aspects and importance for life of an organism. Overview of principles and signalling in various forms of regulated cell death. 2. Caspase-dependent apoptosis: Initiator and effector caspases, their activation, regulation and function. 3. Mitochondria and other organelles in apoptosis; proteins from Bcl-2 family. 4. Intracellular or intrinsic induction of apoptosis, stress response, p53 tumour suppressor. 5. Extracellular or extrinsic induction of apoptosis (death receptors, immune system etc.). 6. Regulated necrosis and other mechanisms of regulated cell death. 7. Final steps in cell destruction, removal of the corpses. 8. Summary of activation and regulation of cell death in mammalian cells. 9. Regulated cell death in other vertebrates and in invertebrates. 10. Regulated cell death in single cell organisms and in plants. 11. Physiology and pathophysiology of regulated cell death; methods of cell death detection and quantification.
Last update: Půta František, doc. RNDr., CSc. (07.02.2018)
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