SubjectsSubjects(version: 953)
Course, academic year 2023/2024
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Molecular mechanisms of regulated cell death - MB150P120E
Title: Molecular mechanisms of regulated cell death
Czech title: Molekulární mechanismy regulované buněčné smrti
Guaranteed by: Department of Cell Biology (31-151)
Faculty: Faculty of Science
Actual: from 2020
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Explanation: nahrazuje MB150P79 a MB150P79E
Note: enabled for web enrollment
Guarantor: RNDr. Ladislav Anděra, CSc.
Teacher(s): RNDr. Ladislav Anděra, CSc.
Incompatibility : MB150P79, MB150P79E
Annotation -
The course of lectures is principally focused on familiarization with the mechanisms of activation and regulation of cell death (apoptosis, regulated necrosis, etc.) and related events. In particular, mammalian (human or mouse) cells are model cells / organisms for analyzing these mechanisms. In addition to mammalian cells, the mechanisms of regulated cell death are presented in other vertebrates, invertebrates and unicellular organisms, and plants. Last but not least, the association between regulated cell death and physiological or pathophysiological states and manifestations of the organism is pointed out.
Last update: Šebková Nataša, RNDr., Ph.D. (24.10.2019)
Literature -

Powerpoint presentations in English accessible after login with password on the web and also on the web accessible updated well-arranged articles or primary publications.

Last update: Šebková Nataša, RNDr., Ph.D. (24.10.2019)
Requirements to the exam -

The exam will be in the extent of the subject matter as a written test containing 3 blocks of questions: a/ section of quiz questions, b/part encompassing short questions and answers and c/ two more complex questions dealing with in detail description or assesment of an important mechanism(s) or process(es) in regulated cell death. 

Academic year: 2020/2021:

During anti-epidemic measures the lectures will be presented online via web using Google meet (timing as regular lecture - i.e. Tuesdays at 13:00).

Contact Email:

Last update: Anděra Ladislav, RNDr., CSc. (12.10.2020)
Syllabus -

1. The concept of apoptosis / programmed cell death, its importance, historical and evolutionary aspects. Overview of principles and signaling pathways, differences between different types of cell death

2. Caspases and other proteases: initiators and effectors of apoptotic signaling, their activation and regulation

3. Mitochondria and other organelles in apoptosis; proteins from the Bcl-2 family.

4. Intracellular induction of apoptosis, stress response, tumor suppressor p53.

5. Extracellular induction of apoptosis (death receptors, immune cells,…)

6. Regulated necrosis and other mechanisms of regulated cell death.

7. Final cell destruction and dead cell removal.

8. Summary of activation and regulation of cell death in mammalian cells in vitro and in vivo.

9. Regulated cell death in other vertebrates and invertebrates.

10. Cell death in unicellular organisms and in plants.

11. Physiology and pathophysiology of cell death; methodology of its detection and quantification.

Last update: Šebková Nataša, RNDr., Ph.D. (24.10.2019)
Entry requirements - Czech

Zvládnout výuku v anglickém jazyce. Zkouška je pro česky mluvící studenty vedena v češtině.

Last update: Šebková Nataša, RNDr., Ph.D. (20.02.2018)
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