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Course, academic year 2023/2024
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The eukaryotic cytoskeleton - MB130P36
Title: Cytoskelet eukaryotní buňky
Guaranteed by: Department of Experimental Plant Biology (31-130)
Faculty: Faculty of Science
Actual: from 2008
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: cancelled
Language: Czech
Note: enabled for web enrollment
Guarantor: Ing. Jiří Hašek, CSc.
Pre-requisite : MB150P31
Opinion survey results   Examination dates   Schedule   
Annotation -
Microtubules, actin microfilaments and intermediate filaments are usually considered
as main components of the cytoskeleton. Together with a number of associated,
structural and regulatory proteins, they provide the cell with important dynamics,
the mechanical support and integrity. Furthermore, exposing a surface comparable
in size with the system of cellular membranes the cytoskeleton may directly affect
functioning of interacting proteins in a number of cellular processes, e.g. by
sequestering of enzymes from their specific targets. Since the cytoskeletal proteins
Last update: VOTRUB (20.03.2003)
Syllabus -

1) Architecture of eukaryotic cells - introduction, components of the cytoskeleton,

conservativity, heterogeneity , modern methods of cytoskeleton studies

(biochemical, immunocytochemical, toxins, molecular biology).

2) Microtubules - structure, dynamics and nucleation; organizing centers (MTOC);

microtubule assemblies, molecular motors and associated proteins; functions of


3) Actin microfilaments - structure and dynamics; actin containing structures;

molecular motors and associated proteins; functions of actin microfilaments.

4)Microtubules and associated proteins in plant cells; Acentrosomal nucleation;

mitosis and cytokinesis.

5) Role of cytoskeletal proteins in controlling gene expression (e.g. in localized

translation and protein trafficking).

6) Signalling and controlling mechanisms of the cytoskeleton organization; role of

cytoskeleton in morphogenesis of plants; role of cytoskleton in cellular reactions to

biotic or abiotic stress.

Last update: VOTRUB (20.03.2003)
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