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Course, academic year 2024/2025
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Introduction to Cell Biology - GB324
Title: Úvod do buněčné biologie
Guaranteed by: Department of Biological and Medical Sciences (16-16150)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: winter
Points: 0
E-Credits: 6
Examination process: winter s.:
Hours per week, examination: winter s.:28/14, C+Ex [HS]
Capacity: unlimited / 90 (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Level:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Mgr. Zuzana Svobodová, Ph.D.
Interchangeability : GB275
Is co-requisite for: GB327
Is interchangeable with: GB275
Annotation -
The main goal of Introduction to Cell Biology is to reveal to the students how the living cell works and teach them how to handle the microscope. Both will give them the background for the subjects in the upcoming years. For that, we introduce them to the structure and function of every single compartment of the cell and its chemical composition. Other areas such as cell communication, cell division, and regulation of the cell cycle are studied. Themes: Structure of prokaryotic and eukaryotic cells, membranes, membrane organelles, DNA and chromosomes, cell communication, cell cycle, reproduction of organisms.
Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Course completion requirements -

To obtain the Credit from Practical classes it is necessary to meet the following conditions:

1)100% presence in all practical classes

2) Deliver the filled-in Laboratory manual to be checked (part of the final evaluation)

3) Credit test that consists of a practical part - to perform one of the tasks from the previous practical classes (fill in the protocol) and answer 3 theoretical questions from practical classes.

When credit is obtained, the student can take the final exam test

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Literature - Czech

Povinná:

  • . . In Alberts, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky . Ústí nad Labem: Espero, 2006, s. -. ISBN 80-902906-2-0..
  • . . In Nečas, Oldřich. Obecná biologie pro lékařské fakulty . Jinočany: H+H, 2000, s. -. ISBN 80-86022-46-3..
  • Uvod do bunecne biologie-ZBIO [online]
  • K procvičení používejte průběžné testy v Moodlu

Last update: prepocet_literatura.php (19.09.2024)
Teaching methods -

Lectures - theory

Moodle - videos, "quizzes", "questions and answers", make-up own "glossary"

Practical classes - independent work with microscope, group work on theoretical tasks

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Requirements to the exam -

The form of an exam is a test composed of 35 questions ( theory and practical classes). Types of questions: single best answer, matching, image description. limit for passing the test: 70% of correct answers evaluation: excellent: 100 % - 90 % very good: 89 % - 80 % good: 79 % - 70 %

The student should show knowledge across the subject of Cell Biology, specifically in the following areas:

1. Definition and general characteristics of cell

2. Structure of prokaryotic cell

3. Structure of eukaryotic cell

4. Cell nucleus 5. Structure of DNA

6. Chromosome structure in prokaryotes and viruses

7. Chromosome structure in eukaryotes

8. Replication, transcription and translation

9. Structure of living systems – water, inorganic substances, low molecular weight organic molecules (saccharides, organic acids, amino acids, nucleotides, phospholipids)

10. Structure of living systems – high molecular weight organic molecules (polysaccharides, proteins, nucleic acids)

11. Membrane structure

12. Cytoplasmic membrane

13. Membrane transport (carrier proteins, ion channels)

14. Mitochondria (structure, cellular respiration)

15. Chloroplasts (structure, photosynthesis)

16. Endoplasmic reticulum

17. Golgi apparatus

18. Endosomes

19. Lysosomes

20. Peroxisomes

21. Intracellular vesicular transport

22. General principles of cell communications

23. Receptors (basic characteristics, signaling cascade)

24. Ion-channel–coupled receptors

25. G-protein–coupled receptors 26. Enzyme–coupled receptors 27. Microtubules 28. Actin filaments

29. Intermediate filaments

30. Cell cycle

31. Mitosis

32. Meiosis

33. Cell cycle control system

34. Cell differentiation

35. Cell death

36. Cell stress

37. Asexual reproduction 38. Spermatogenesis 39. Oogenesis 40. Fertilization

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
Syllabus -

Cell structure
· definition and general characteristics of cell (cell theory)
· structure of prokaryotic cell
· structure of eukaryotic cell (plant and animal)
Chemical composition of living systems
· water and inorganic substances
· low molecular weight organic molecules: saccharides, organic acids, amino acids, nucleotides,
phospholipids
· high molecular weight organic molecules: polysaccharides, proteins, nucleic acids
Nucleic acids and chromosomes I
· structure of DNA
· chromosome structure in prokaryotes and viruses
· chromosome structure in eukaryotes
Nucleic acids and chromosomes II
· replication
· transcription
· translation
Membranes I
· membrane structure
o lipid bilayer
o molecular structure of membranes – lipids, proteins, saccharides
· cytoplasmic membrane
Membranes II
· membrane transport
· carrier proteins
· ion channels and the electrical properties of membranes
Membrane organelles I
· mitochondria
o the structure
o cellular respiration – Krebs cycle, electron-transport chain, oxidative phosphorylation
· chloroplasts
o the structure
o photosynthesis – light reactions and dark reactions
Membrane organelles II
· endoplasmic reticulum
· Golgi apparatus
· endosomes
· lysosomes
· peroxisomes
· intracellular vesicular transport
o transport from the endoplasmic reticulum through the Golgi apparatus
o transport from the trans Golgi network to lysosomes
o transport into the cell from the plasma membrane: endocytosis
o transport from the trans Golgi network to the cell exterior: exocytosis
Cell communications
· general principles of cell communication
· signal molecules
· receptors
o ion-channel–coupled receptors
o G-protein–coupled receptors
o enzyme–coupled receptors
Cell division
· cell cycle - four phases (G1, S, G2, M)
· mitosis - prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis
· meiosis
Cell cycle control system
· regulation of the cell cycle
· cell differentiation
· cell death
Reproduction of organisms
asexual reproduction
characteristics
binary division, vegetative reproduction, amitosis
sexual reproduction
characteristics
gametogenesis - spermatogenesis, oogenesis, fertilization

Last update: Svobodová Zuzana, Mgr., Ph.D. (21.08.2024)
 
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