Organic Chemistry I - GAF391
Title: Organic Chemistry I
Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: winter
Points: 0
E-Credits: 6
Examination process: winter s.:written
Hours per week, examination: winter s.:28/20, C+Ex [HS]
Capacity: unlimited / 90 (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. RNDr. Milan Pour, Ph.D.
Is co-requisite for: GAF299
Is interchangeable with: GAF285
Examination dates   WS schedule   
Annotation -
Organic Chemistry I is a preparatory subject, focused on nomenclature and relationships between structure and physical properties of organic compounds, important for their application as chemical drugs. Emphasis is put on chemical drugs as small organic molecules, the properties and architecture of which determines transport in human organism and interaction with receptors. The subject thus enables the students to follow up in specialized pharmaceutical disciplines, primarily Pharmaceutical Chemistry, but also Pharmacognosy, Biochemistry and Pharmacology. Topics: Nomenclature of Organic Compounds, Structure of Organic Compounds, Polarity of Bonds and Related Physical Properties, Intermolecular Attractive Forces and Related Physical Properties, Physical Methods of Structure Elucidation.
Last update: Pour Milan, prof. RNDr., Ph.D. (03.10.2023)
Course completion requirements -

The subject is completed by gaining credit and passing an examination, both in the form of a written test. The credit is awarded for 100% attendance at seminars and obtaining a minimum of 60% of the total points from two credit tests to be taken in the 6th and 10th seminars. Each credit test will be composed of 5 questions, each answer worth two points . The first test will be focused on simple nomenclature and stereochemistry, the second one will be focused on basic physical and spectral properties of organic compounds. In the case of being unsuccessful, the student will have three more resit attempts for the credit tests in the exam period. The resit test will be composed of five questions comprising all the above topics, each answer marked with a maximum of two points if correct; the credit will be awarded for obtaining a minimum of 60% of the total number of points.

The examination test will be composed of 10 questions, each answer marked with a maximum of two points if correct. A minimum of 60% of the total points is again required to pass the examination.

Last update: Pour Milan, prof. RNDr., Ph.D. (03.10.2023)
Syllabus -

Organic Chemistry I

Systematic nomenclature of organic compounds 

  • Importance of Organic Chemistry in Pharmacy 
  • Introduction to systematic nomenclature according to IUPAC
  • Saturated cyclic base components: bicycles, spirocycles, steroids
  • Unsaturated cyclic base components: monocyclic and orthofused aromates
  • Heterocyclic base components: Hantzsch-Widman system, orthofused heterocycles

Structure of organic compounds

  • Types of chemical bonds in organic compounds
  • Isomerism, constitutional isomers, stereoisomers
  • Chirality, enantiomers, diastereomers, descriptors R,S; D,L; E,Z
  • Conformations, conformational analysis

Polarity of bonds and related physical properties

  • Distribution of electron density in organic molecules
  • Inductive effect, resonance theory, mesomeric effect
  • Dipole moment, relative permitivity
  • Acidity and basicity in relationship to structure, basic terms.
  • O, S, N and C-acids

Attractive forces among molecules and related physical properties

  • Overview and importance of intermolecular attractive forces
  • Relationships between structure/melting points, boiling points and soulubility in water

Physical methods of structure elucidation

  • Introduction to molecular spectroscopy
  • UV and IR spectroscopy
  • NMR spectroscopy
  • Other methods: X-ray analysis, mass spectrometry
Last update: Pour Milan, prof. RNDr., Ph.D. (03.10.2023)
Learning outcomes

   

Subject Organic Chemistry I follows up on the knowledge and skills acquires in subjects: General and Bioinorganic chemistry

Following the completion of the subject, the students are able to use the following terms (including their commonly used abbreviations) in the correct context towards the names and properties of organic compounds: nomenclature, IUPAC, chemical bond, structure, stereochemistry, centre of chirality, enantiomers, diastereomers, conformation, inductive effect, mesomeric effect, acidity, basicity, intermolecular attractive forces, melting point, boiling point, solubility, physical methods, UV/VIS, IR, NMR, MS, X-ray analysis, polarimetry.

Learning outcomes:

Based on the knowledge and skills acquired, students:

Ø  define the importance of Organic Chemistry in the context of Pharmaceutical Sciences;

Ø  have a good command  of the nomenclature of organic compounds;

Ø  identify functional groups, heterocycles and aromatic rings in a given compound

Ø  describe spatial arrangement of organic compounds related to their structure;

Ø  explain the distribution of electron density in the molecules of organic compounds;

Ø  estimate physical properties of organic compounds, depending on structure, with emphasis on acidobasic properties and water solubility;

Ø  evaluate and interpret data obtained by physical methods and elucidate structure using this data;

Ø  suggest a suitable physical method to determine the structure of an unknown compound.

Last update: Pour Milan, prof. RNDr., Ph.D. (28.03.2025)