SubjectsSubjects(version: 941)
Course, academic year 2023/2024
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Xenobiochemistry - GAF237
Title: Xenobiochemistry
Guaranteed by: Department of Biochemical Sciences (16-16160)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: winter
Points: 0
E-Credits: 3
Examination process: winter s.:oral
Hours per week, examination: winter s.:28/14, Ex [HS]
Capacity: 50 / 50 (unknown)
Min. number of students: unlimited
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: (F 3.r.)
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. Ing. Vladimír Wsól, Ph.D.
Co-requisite : GAF141
Is co-requisite for: GAF267, GAF361
Annotation -
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
Xenobiochemistry provides the basics necessary for understanding of xenobiotic metabolism, especially drugs and contaminants of environment. It explains the causes of the pharmacological and toxicological consequences of their presence in the living organism. In the subject Xenobiochemistry, the students gain basic knowledge on the metabolism of xenobiotics in the organism, biotransformation enzymes and transport systems and factors influencing the metabolism of xenobiotics.
Course completion requirements
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)

Before the planned exam, it is necessary to obtain credit, by successfully defending the seminar work, which must be registered in the SIS. The exam is only oral. Detailed information is always in folders on the web for the subject.

Literature - Czech
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)


  • Gibson, G. Gordon Skett, Paul. Introduction to drug metabolism. Cheltenham, UK: Nelson Thornes Publishers, 2001, 256 s. ISBN 0-7487-6011-3.
  • Xenobiochemistry [online]. Dostupné z:

Syllabus -
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
  1. Pathways of drug metabolism

    Introduction, Phase I metabolism (oxidation, reduction, hydrolysis, hydration), Phase II metabolism (conjugation with sugars, sulfation, methylation, acetylation, amino acid conjugation, glutathione conjugation, fatty acid conjugation)

  2. Enzymology and molecular mechanisms of drug metabolism reactions

    Introduction, oxidases (cytochrome P450 superfamily, Flavin-containing monooxygenases), reductases (Aldo-keto reductase superfamily, SDR superfamily), transferases

  3. Induction and inhibition of drug metabolism

    Introduction, induction of drug metabolism in experimental animals and man, molecular mechanisms of induction, molecular mechanisms of inhibition

  4. Factors affecting drug metabolism: Internal factors

    Introduction, species differences, genetic differences, age, hormonal control of drug metabolism, the effect of disease

  5. Factors affecting drug metabolism: External factors

    Dietary factors, environmental factors

  6. The clinical relevance of drug metabolism

    Introduction, Pharmacokinetics, Methods for studying drug metabolism in man, clinical relevance of drug metabolism



PowerPoint presentation of seminar work of students (one chosen clinically relevant enzyme for each student)

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