Immunopharmacology - GAF234

• Title: Immunopharmacology
• Guaranteed by: Department of Biological and Medical Sciences (16-16150)
• Faculty: Faculty of Pharmacy in Hradec Králové
• Actual: from 2024
• Semester: summer
• Points: 0
• E-Credits: 3
• Examination process: summer s.:combined
• Hours per week, examination: summer s.:28/14, C+Ex [HS]
• Capacity: unlimited / unlimited (30)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Explanation: (F 3.r.)
• Note: deregister from the exam date if a requisite was not fulfilled; course can be enrolled in outside the study plan; enabled for web enrollment
• Guarantor: PharmDr. Jana Urbánková Rathouská, Ph.D.
• Co-requisite : GAF143

Annotation

English

Immunopharmacology (rarely lectured in Europe) extends knowledge of the subject of immunology and responds to the rapid development of immune modulating drugs. These include, in particular, medicines used in transplant medicine, allergy and clinical immunology, and immunomodulation procedures applied in oncology. In particular, issues of immunity and vaccine prevention, as well as the side immunotoxic and allergenic effects of other drugs and xenobiotics are discussed. Attention is also paid to the relationship between immune and neurohumoral regulation systems, the influence of stress, nutrition and the environment on immunity. Practical aspects of immunopharmacological therapy are presented. Students have the opportunity to study in detail the specific problem of immunopharmacotherapy and thus gain experience in the field of medical informatics.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Czech

Imunofarmakologie (v Evropě zřídka přednášená) rozšiřuje znalosti z předmětu imunologie a reaguje tak na prudký rozvoj používání léků modulujících imunitu. Jde zejména o léčiva užívaná v transplantační medicíně, alergologii a klinické imunologii, dále imunomodulační postupy aplikované v onkologii. Podrobněji jsou diskutovány otázky prevence poruch imunity a vakcinace, stejně jako vedlejší imunotoxické a alergizačním účinky ostatních léčiv a xenobiotik. Pozornost je věnována i vztahům mezi systémy imunitní a neurohumorální regulace, vlivu stresu, výživy a životního prostředí na imunitu. Praktické aspekty terapie imunofarmaky přednášejí špičkoví kliničtí imunologové. V klausurních pracích mají studenti možnost podrobně prostudovat určitý problém imunofarmakoterapie a tím získat zkušenosti i z oblasti zdravotnické informatiky.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Course completion requirements

Attaining a credit and passing exam.

For the credit, it is necessary to complete the exercises without unauthorized absences. The exam consists of a multiple choice test, a written miniassay and an oral test. The evaluation of all three parts is complex.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (30.03.2025)

Literature

Povinná:

• Nijkamp P., Parnham M. J (Eds.). Principles of Immunopharmacology. Berlin: Springer, 2011, 728 s. ISBN 978-3-0346-0136-8.

Doporučená:

• Klein, Jan, Hořejší, Václav. Immunology. Oxford: Blackwell, 1999, 722 s. ISBN 0-632-05468-9.

Volitelná:

• Rich, Robert R. (ed.). Clinical immunology : principles and practice. London: Mosby Company, 2001, 63 s. ISBN 0-7234-3161-2.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (30.03.2025)

Teaching methods

Lectures, seminars, self-study with the use of recommended literature and supporting materials.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Syllabus

English

• Active immunization, vaccines technology, perspective vaccines, means of passive immunization, antibodies in therapy, monoclonal antibodies, immunoconjugates - specific drug targeting, immunotoxins.

• Therapeutic use of cytokines, immunomodulators of microbial origin, thymic hormones and synthetic immunostimulators.

• Drugs for immunosupressive therapy: corticosteroids, antimetabolites and calcineurine inhibitors.

• Therapy and prevention of allergic diseases and drug hypersensitivity.

• Relationships between immune and neurohumoral regulations, influence of stress, nutrition and environment on immunity.

• Basic immunotoxicology - principles of testing of immunomodulating and immunotoxicological properties of drugs and xenobiotics.

• Clinical aspects of antiallergic, immunosuppressive, immunostimulating and substitutive therapy.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Czech

• Aktivní imunizace, technologie vakcín, perspektivní očkovací látky, prostředky pasivní imunizace, protilátky v terapii, monoklonální protilátky, protilátkami cílená distribuce léčiv, imunotoxiny.

• Terapeutické použití cytokinů, imunomodulátory mikrobiálního původu, hormony thymu, syntetická imunostimulancia.
• Farmaka pro imunosupresivní terapii - kortikoidy, antimetabolity, cyklosporiny, imunomodulační účinky ionizujícího záření.
• Terapeutické možnosti u alergiků, přecitlivělost na léky.
• Vztahy mezi systémy imunitní a neurohumorální regulace, vliv stresu, výživy a životního prostředí na imunitu.
• Principy testování imunomodulačních a imunotoxických vlastností léčiv a xenobiotik.
• Klinické aspekty protialergické, imunosupresivní, imunostimulační a substituční terapie.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Learning resources

Essential supports are given in each lecture and are also discussed in seminars.

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (14.02.2025)

Learning outcomes

Immunopharmacology subject expands on the knowledge gained in the Immunology course and responds to the rapid development of drugs that modulate immunity. The main areas of interest include vaccinology, transplant medicine, cancer therapy, immunotherapy of allergic reactions, immunodeficiencies, and autoimmune diseases. An integral part of the course also covers drug hypersensitivity and immunotoxicology.

Upon completing the course, students will be able to explain and use the following terms in the correct context: vaccine, active immunization, passive immunization, monoclonal antibodies, immunotoxins, antibody-targeted drug delivery, cytokines, interferons, interleukins, tumor necrosis factor (TNF), immunomodulators, synthetic immunostimulants, thymic hormones, corticosteroids, antimetabolites, cyclosporins, immunosuppressants, hypersensitivity, allergy, anaphylaxis, antihistamines, immune tolerance, autoimmune reactions, immunotoxicity, immunological homeostasis, probiotics, adjuvant, xenobiotics.

Learning outcomes:

Based on the acquired knowledge and skills, students will:

Ø  Explain the principles of active and passive immunization, describe vaccine technologies, and new prospective vaccines.

Ø  Characterize the therapeutic use of antibodies, monoclonal antibodies, and their application in targeted drug delivery and immunotoxins.

Ø  Describe the use of cytokines, microbial-derived immunomodulators, thymic hormones, and synthetic immunostimulants in therapy.

Ø  Analyze drugs used in immunosuppressive therapy, including corticosteroids, antimetabolites, and cyclosporins, and explain the immunomodulatory effects of ionizing radiation.

Ø  Discuss therapeutic approaches for allergies and drug hypersensitivity.

Ø  Describe the relationships between the immune system and neurohumoral regulation, as well as the impact of stress, nutrition, and environmental factors on immunity.

Ø  Explain the principles of testing the immunomodulatory and immunotoxic properties of drugs and xenobiotics.

Ø  Evaluate the clinical aspects of antiallergic, immunosuppressive, immunostimulatory, and replacement therapy.

 

Last update: Urbánková Rathouská Jana, PharmDr., Ph.D. (30.03.2025)