Histology and Embryology II - EA0903015
Title: Histology and Embryology II
Guaranteed by: Ústav histologie a embryologie (14-40)
Faculty: Faculty of Medicine in Pilsen
Actual: from 2024
Semester: winter
Points: 4
E-Credits: 4
Examination process: winter s.:
Hours per week, examination: winter s.:1/2, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
For type:  
Note: deregister from the exam date if a requisite was not fulfilled
for a repeated registration for Course credit + Exam, the student must have the Course credit exam passed
Guarantor: prof. MUDr. Mgr. Zbyněk Tonar, Ph.D.
prof. MUDr. Milena Králíčková, Ph.D.
Teacher(s): doc. Mgr. Yaroslav Kolinko, Ph.D.
doc. Ing. Jan Nevoral, Ph.D.
prof. MUDr. Mgr. Zbyněk Tonar, Ph.D.
Co-requisite : EA0902001, EA0902004
Is co-requisite for: EA0905370, EA0906470, EA0905500, EA0905510, EA0906100, EA0906520, EA0906090
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Annotation -
The students will learn and understand how to describe the microscopic structure of various organs of human body. In the practical classes, the students will optical microscope for identification and description of histological slides. The students will learn about the development of human body, starting with formation of gametes, fertilization, through early embryonic development, organogenesis, fetal growth, and finally up to birth. The students will learn about the main phases of development of individual organs and organ systems in order to understand the origin of the most common malformations.
Last update: Jiráková Lucie, Bc. (25.10.2022)
Course completion requirements -

The conditions for completing the course are described in the document Histology credit exam and Histology and Embryology II final exam rules in the academic year 2023/24 (see above).

Last update: Jiráková Lucie, Bc. (15.09.2023)
Literature -

•Slípka J.: Outlines of histology. Karolinum 2017

•Slípka J.: Outlines of embryology. Karolinum 2019

•Mescher A.L.: Junqueira´s Basic Histology. Text and Atlas. 16th edition. McGrawHill, New York, 2021

•Ovalle W., Nahirney P.: Netter´s Essential Histology, 2nd edition, Elsevier 2013

•Gartner L.P., Hiatt J.L.: Color Atlas and Text of Histology. 6th edition. Wolters Kluwer, 2014

•Ross M., Pawlina W.: Histology: a Text and Atlas with Correlated Cell and Molecular Biology. 6th edition. Wolters Kluwer, 2014

•Young B., Woodford P., O´Dowd G.: Wheater´s Functional Histology. A text and colour atlas. 6th edition, Churchill Livingstone, 2013

•Sadler T.: Langman´s Medical Embryology, 15th edition, Wolters Kluwer 2023

•Moore K.L., Persaud T.V.N., Torchia M.G.: Before We Are Born, 9th Edition. Elsevier, Philadelphia, 2016

•Moore K.L., Persaud T.V.N., Torchia M.G.: The Developing Human, 10th Edition. Clinically Oriented Embryology. Elsevier, Philadelphia, 2016

 

 

Last update: Jiráková Lucie, Bc. (14.11.2023)
Requirements to the exam -

The conditions for completing the course are described in the document Histology credit exam and Histology and Embryology II final exam rules in the academic year 2023/24 (see above).

Last update: Jiráková Lucie, Bc. (15.09.2023)
Syllabus -

 Summary of the lectures - Embryology. Dental medicine 2nd year:

1. INTRODUCTION: Embryological terms. The ethical problems of Embryology. History of embryology. Blastogenesis. Fertilization and differentiation. Cleavage.

2. BLASTOGENESIS and GASTRULATION: Blastocyst, Implantation, Gastrulation. Origin of the first Germ layers. Notogenesis (development of notochord).

The embryonic disc and its development. Mesoderm and development of somites. Mesenchyme.

3. FETAL MEMBRANES AND PLACENTA DEVELOPMENT: Amniotic sac expansion. Rotation of embryo. Amnion. Chorion. Placenta. Embryonic and fetal growth. Marks of the fetal maturity. Delivery.

4. NERVOUS SYSTEM DEVELOPMENT: Neural plate, groove and tube. Brain vesicles. Development of sense organs. The eye and inner ear.

5. CIRCULATORY SYSTEM DEVELOPMENT I.: First embryonic and extraembryonic circulation. Development of major vessels. Aortal arches. Veins.

6. CIRCULATORY SYSTEM. DEVELOPMENT II.: Heart loop. Septation of the atria and ventricles. Common cardial malformations.

7. DIGESTIVE SYSTEM DEVELOPMENT I.: Delimitation of the yolk sac. Archenteron. Stomodeum. Branchial region. Teeth.

Derivatives of the branchial clefts, pouches and arches. Development of Tongue.

8. DIGESTIVE and RESPIRATORY SYSTEM DEVELOPMENT: Rotation of Intestine. Liver, Pancreas and Spleen Development. Respiratory passages and Lung Development.

9. URINARY SYSTEM DEVELOPMENT: Pronephros. Mesonephros. Metanephros. Urinary passages. Cloaca.

10. GENITAL SYSTEM DEVELOPMENT: Gonade. Wolffian and Müllerian ducts. External genital organs.

11. OROFACIAL REGION, SKULL and SKELETAL DEVELOPMENT: Nose. Olfactory organ.Upper and lower jaws development. Development of the secondary Palate.

Cleft malformations. Axial skeleton. Extremities. Skull. Muscles and Skin Development.

12. Problem based lecture

13. Problem based lecture

Summary of the practical sessions. Systematic histology.
Dental medicine 2nd year. Winter term.

 

1.        Introduction, revision. The rules of health security during the teaching process of Histology.

Oral cavity I.: tongue (radix linguae, dorsum linguae), soft palate, lip.

2.       Oral cavity II.: Tooth development. Histology of tooth tissues and periodontium. Large salivary glands: submandibular and sublingual gland, parotid gland.  

3.       Digestive system I.: oesophagus, stomach, pancreas.

4.       Digestive system II.: duodenum, appendix vermiformis, liver, gall bladder

5.        Respiratory system: epiglottis, trachea, lung.

Urinary system: kidney, ureter, urinary bladder.

6.       Male reproductive system: testis, epididymis, prostate, spermatic cord.

7.        Female reproductive system I.: ovary, uterine tube, uterus, pregnant uterus, placenta, umbilical cord, vagina.

8.       Cardiovascular system: myocard, aorta, artery and vein of the lower extremity, vessels of various organs, capillaries.

9.        Lymphatic vessels and organs: lymph node, tonsils, spleen, thymus.

10.   Endocrine system: hypophysis, suprarenal gland, thyroid gland.

11.     Nervous system: spinal cord, cerebellum, cerebral cortex, peripheral nerve, ganglion.

12.    Skin: Thick and thin type - planta pedis, axilla, eyelid, auricle, mammary gland (inactive and lactating).

13.    Embryology: tooth development, secondary palate, and mandible development, cleft defects.  

14.    Revision of the whole topic. Examination. Course credit.

TEST 1: 21.10 - 8.11. 2024

TEST 2: 25.11. - 13.12. 20244

TEST 3: 9.12. 2024 - 3. 1. 2025

FINAL TEST: from 1. 1. 2025

Last update: Merhautová Šárka (17.09.2024)
Learning resources -

MOODLE courses: Course: Embryology (cuni.cz); Kurz: Special Histology for Dental Medicine (cuni.cz)

YouTube channel is available: https://www.youtube.com/channel/UCY7dMERswmElzXGF1JDA4vA/featured?disable_polymer=1

Website of the Department: http://histologie.lfp.cuni.cz/?lang=en

PRACTICAL EXCERCISES:

Collection of digitized slides at: https://lfp.smartzoom.com

A list of recommended literature can be found at the link: http://histologie.lfp.cuni.cz/index.php/doporucena-literatura/?lang=en

Last update: Merhautová Šárka (17.02.2025)
Learning outcomes -

Upon completion of the course, the learner will be able to:
  • Classify the types of tissues, cells and components of intercellular matter in organs of the human body.

  • Define and use in the correct context the terms necessary to describe the normal microscopic structure of the organs of the human body.

  • Identify and systematically describe in histological slides the structures important for comparison and differentiation in histological slides of normal human organs, using both light microscopy and scanned virtual slides.

  • Draw and describe simplified diagrams of microscopic preparations of human body organs.

  • Explain the structures on the slide to a second observer (learner or teacher).

  • Identify the organs of the human body from which the microscopic slides were taken.

  • Correlate the microscopic structure of human organs with their function.

  • Describe and explain fertilization, embryonic and fetal body formation, and prenatal organogenesis.

  • Explain the anatomical structure and variability of the organs of the human body in terms of their prenatal development in the following organ systems: cardiovascular, nervous, digestive, respiratory, musculoskeletal.

  • Discuss on these topics with an emphasis on the application of this knowledge in contemporary medicine.

  • Solve simplified problems based on knowledge and skills in histology and embryology within the range of recommended resources and learning outcomes detailed for each topic.


Detailed learning outcomes for each topic:


https://histologie.lfp.cuni.cz/wp-content/uploads/sites/2/2024/03/Learning-objectives-for-2nd-year-Histology.pdf
https://histologie.lfp.cuni.cz/wp-content/uploads/sites/2/2024/03/Learning-objectives-for-Embryology.pdf

Last update: Merhautová Šárka (26.06.2024)
 
Schedule scheduled
Schedule ticket Date From - To Education type Theme Teacher Files NoteHodnocení
24aEA0903015p1

Groups of students
2.AZUBL18		Wed 02.10.2024 14:00 - 15:40 lecture Fertilization and early embryonic development: Spermio- and oogenesis. Fertilization and preimplantation embryonic development. Mitochondria inheritance. Embryonic genome activation. Differentiation to embryoblast and trophectoderm. prof. MUDr. Mgr. Zbyněk Tonar, Ph.D.
Wed 09.10.2024 14:00 - 15:40 lecture Blastocyst, embryo nidation, gastrulation: Blastocyst formation, blastocoel, blastocyst hatching, embryo implantation, gastrulation. doc. Ing. Jan Nevoral, Ph.D.
Wed 16.10.2024 14:00 - 15:40 lecture Notogenesis, embryonic disc, mesoderm and somites: Development of dorsal chord. Origin of germ layers and formation of embryonic disc. Mesoderm and somites. Mesenchyme. doc. Ing. Jan Nevoral, Ph.D.
Wed 23.10.2024 14:00 - 15:40 lecture Placentation, fetal membranes, delivery: Chorionic sac, amniotic sac, and its expansion. Flexure of the embryo. Amniotic fluid. Placentation. Embryonic and fetal growth. Marks of the fetal maturity. Delivery. doc. Ing. Jan Nevoral, Ph.D.
Wed 30.10.2024 14:00 - 15:40 lecture Nervous system development: Neural plate, neural groove and neural tube. Brain vesicles. Development of sense organs. The eye and inner ear. doc. Ing. Jan Nevoral, Ph.D.
Wed 06.11.2024 14:00 - 15:40 lecture Circulatory system, part I: Embryonic yolk circulation. First embryonic circulatory system. Major vessels and aortal arches. Features of main vessels. prof. MUDr. Mgr. Zbyněk Tonar, Ph.D.
Wed 13.11.2024 14:00 - 15:40 lecture Circulatory system, part II: Heart tube and loop, Septation of the atria and ventricles. Common cardiac malformations. doc. Ing. Jan Nevoral, Ph.D.
Wed 20.11.2024 14:00 - 15:40 lecture Digestive system, part I: Delimitation of the yolk sac and primitive gut. Foregut, pharynx. Derivatives of the branchial clefts, pouches and arches. Stomodeum. Development of tongue. Development of teeth. doc. Mgr. Yaroslav Kolinko, Ph.D.
Wed 27.11.2024 14:00 - 15:40 lecture Digestive system, part II & Respiratory system: Duodenum, liver, and pancreas. Midgut and rotation of intestine. Hindgut. Body cavities. Spleen development. Respiratory passages and lung development. Ing. Bc. Lucie Vištejnová, Ph.D.
Wed 04.12.2024 14:00 - 15:40 lecture Development of urinary system: Development of pronephros, mesonephros, and metanephros. Urinary passages. Cloaca. doc. Mgr. Yaroslav Kolinko, Ph.D.
Wed 11.12.2024 14:00 - 15:40 lecture Development of genital system: Development of gonads. Wolffian and Müllerian ducts. External genital organs. MUDr. Věra Křížková, Ph.D.
Wed 18.12.2024 14:00 - 15:40 lecture Orofacial region, skull, and skeleton: Nose and olfactory organ. Upper and lower jaw development. Development of the secondary palate. Cleft malformations. Development of axial skeleton, extremities. Muscles and skin development. doc. Ing. Jan Nevoral, Ph.D.
Wed 08.01.2025 14:00 - 15:40 lecture Solving model questions for the embryology exam. Case-based discussion: Want to know if you are well prepared? Come and try solving mock exam questions before taking the official exam! Interactive problem-based lecture. Students will use their own knowledge of embryology to solve real medical problems. prof. MUDr. Mgr. Zbyněk Tonar, Ph.D.