Glutathion a glutathion dependentní enzymy za různých patofyziologických stavů.
| Název práce v češtině: | Glutathion a glutathion dependentní enzymy za různých patofyziologických stavů. |
|---|---|
| Název v anglickém jazyce: | Glutathione and glutathione-dependent enzymes in various pathophysiological states. |
| Klíčová slova: | oxidační stres, antioxidační systém, sepse, deprese, metabolický syndrom, akutní a chronická pankretitida, karcinom pankreatu, glutathionperoxidasa, glutathionreduktasa, redukovaný glutathion |
| Klíčová slova anglicky: | oxidative stress, antioxidant enzymes, depressive disorder, metabolic syndrome, sepsis, acute and chronic pancreatitis, pancreatic cancer, glutathione peroxidase, glutathione reductase, reduced glutathione |
| Akademický rok vypsání: | 2012/2013 |
| Typ práce: | disertační práce |
| Jazyk práce: | angličtina |
| Ústav: | IV. interní klinika – gastroenterologie a hepatologie 1. LF UK a VFN (11-00540) |
| Vedoucí / školitel: | RNDr. Eva Tvrzická, CSc. |
| Řešitel: | skrytý - zadáno a potvrzeno stud. odd. |
| Datum přihlášení: | 24.04.2013 |
| Datum zadání: | 24.04.2013 |
| Datum potvrzení stud. oddělením: | 24.04.2013 |
| Datum a čas obhajoby: | 30.09.2013 14:00 |
| Místo konání obhajoby: | Děkanát 1. LF UK |
| Datum odevzdání elektronické podoby: | 17.07.2013 |
| Datum proběhlé obhajoby: | 30.09.2013 |
| Předmět: | Obhajoba dizertační práce (B90002) |
| Oponenti: | Ing. Ludmila Kazdová, CSc. |
| MUDr. Martin Vejražka, Ph.D. | |
| Seznam odborné literatury |
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| Předběžná náplň práce |
| Náplní dizertační práce bude stanovení hladin redukovaného glutathionu a aktivit glutathion-dependentních enzymů - glutathionperoxidasy, glutathionreduktasy v erytrocytech pacientů s různými patofyziologickými stavy - s depresivní poruchou, metabolickým syndromem, sepsí, akutní a chronickou pankreatitidou a karcinomem pankreatu. Tyto parametry budou dále porovnány se zdravými kontrolami párovanými věkem a pohlavím k výše uvedeným pacientům. |
| Předběžná náplň práce v anglickém jazyce |
| The aim of doctoral thesis will be determination of glutathione levels and activities of glutathione – dependent enzymes such as glutathione peroxidase and glutathione reductase in patients with various pathophysiological states - major depressive disorder, metabolic syndrome, sepsis, acute and chronic pancreatitis and pancreatic cancer. These parameters will be compared with age- and sex- matched healthy controls. |