Genetické faktory podílející se na vzniku metabolického syndromu

• Název práce v češtině: Genetické faktory podílející se na vzniku metabolického syndromu
• Název v anglickém jazyce: Genetic factors responsible for development of metabolic syndrome
• Klíčová slova: metabolický syndrom, potkanní modely, transkriptomika, hypertenze, dyslipidémie, kandidátní geny, Plzf, Nr4a1, Acsm3.
• Klíčová slova anglicky: metabolic syndrome, rodent models, transcriptome analysis, hypertension, dyslipidemia, candidate genes, Plzf, Nr4a1, Acsm3.
• Akademický rok vypsání: 2014/2015
• Typ práce: disertační práce
• Jazyk práce: čeština
• Ústav: Ústav biologie a lékařské genetiky 1. LF UK a VFN (11-00160)
• Vedoucí / školitel: doc. MUDr. František Liška, Ph.D.
• Řešitel: skrytý - zadáno a potvrzeno stud. odd.
• Datum přihlášení: 06.10.2014
• Datum zadání: 06.10.2014
• Datum potvrzení stud. oddělením: 06.10.2014
• Datum a čas obhajoby: 12.09.2023 10:00
• Místo konání obhajoby: v seminární místnosti BiolS3, přízemí vpravo, Ústav biologie a lékařské genetiky 1. LF UK a VFN, Albertov 4, Praha 2
• Datum odevzdání elektronické podoby: 23.06.2023
• Datum proběhlé obhajoby: 12.09.2023
• Předmět: Obhajoba dizertační práce (B90002)
• Oponenti: prof. MUDr. Marie Černá, DrSc.

Seznam odborné literatury

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Předběžná náplň práce

Hlavním cílem této práce bylo identifikovat genetické determinanty stojící za metabolickým syndromem a upřesnit roli Plzf u těchto determinant.
1. Objasnit genetické pozadí vedoucí ke zlepšení krevního tlaku a srdeční fibrózy u minimálního kongenního kmene PD5
2. Provedení komparativní transkriptomické a fenotypové analýzy u potkaních kmenů PD a SHR po zatížení dietou s vysokým obsahem tuku a odkrytí patofyziologikých mechanismů náchylnosti potkaního kmene PD k metabolickému syndromu.
3. rovedení komparativní transkriptomické a fenotypové analýzy u potkaních kmenů PD5 a SHR před a po podání dexametazonu s cílem plně odhalit roli Plzf při rozvoji metabolického syndromu.

Předběžná náplň práce v anglickém jazyce

The aims of the thesis
The chief goal of this work was to identify genetic determinants underlying metabolic syndrome and to dissect the role of Plzf within the complex network of these determinants.
1. Elucidate the genetic background leading to amelioration of blood pressure and cardiac fibrosis in SHR minimal congenic strain PD5
2. Compare transcriptional and phenotypic changes in PD and SHR rat strains after high fat diet and unravel pathophysiological mechanisms underlying PD susceptibility to metabolic syndrome.
3. Compare transcriptional and phenotypic changes in PD5 and SHR rat strains before and after dexamethasone administration in order to fully uncover the role of Plzf in development of metabolic syndrome.