Regulatory roles of the microtubule envelope
| Název práce v češtině: | Regulační role mikrotubulové obálky |
|---|---|
| Název v anglickém jazyce: | Regulatory roles of the microtubule envelope |
| Akademický rok vypsání: | 2024/2025 |
| Typ práce: | disertační práce |
| Jazyk práce: | angličtina |
| Ústav: | Katedra buněčné biologie (31-151) |
| Vedoucí / školitel: | RNDr. Zdeněk Lánský, Ph.D. |
| Řešitel: |
| Seznam odborné literatury |
| Suggested reading: Siahaan V et al, Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes. Nat Cell Biol. 2019 Sep;21(9):1086-1092 Schmidt-Cernohorska M, et al, Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails. Science. 2019 Jan 18;363(6424):285-288. Hernández-Vega A et al, Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Rep. 2017 Sep 5;20(10):2304-2312 |
| Předběžná náplň práce |
| Lab profile: Cytoskeletal networks form the internal dynamic scaffold of living cells essential for key cellular processes, such as cell division, cell motility or morphogenesis. Our aim is to understand how the individual structural elements of the cytoskeleton mechanically cooperate to drive these cellular processes. We use reconstituted cytoskeletal systems to study the system's self-assembly and dynamics. Central to our approach are imaging, manipulation and force measurement techniques with single molecule resolution. Project description: Modulating the accessibility of the cytoskeletal filaments for the filament-associated proteins is one of the fundamental regulatory mechanisms in the cytoskeleton. Unstructured microtubule-associated proteins, such as the Alzheimer's disease-associated protein tau, can form cohesive envelopes around microtubules, selectively modulating the microtubule accessibility by locally excluding specific proteins from the microtubule surface while recruiting others. The aim of the project is to explain the envelope formation and its regulatory and (patho)physiological roles. Candidate profile: We are looking for an enthusiastic PhD student motivated to work on cross-disciplinary projects. The candidate should hold a master's degree in (bio)chemistry, (bio)physics, molecular/cellular biology or an equivalent field. |