Cílem práce je získat nové informace o vodíkových vazbách mezi látkami s biologickou aktivitou a o strukturních změnách vyvolaných mezimolekulovými interakcemi.
Předběžná náplň práce v anglickém jazyce
The aim of the PhD project is to bring new information about intermolecular H-bonding of biologically important molecules and about structural adaptations induced by a binding partner capable of H-bonding. A methodology based on NMR experiments for the determination of free energy changes upon hydrogen bond formation will be developed. The student will investigate, for example, H-bonding interactions between modified bases of nucleic acids. The model compounds will be synthesised in collaborating IOCB labs. The experimental data will be supported with DFT calculations of complexation energies and NMR parameters.