Vliv parazita Toxoplasma gondii na produkci hlavních močových proteinů u myši domácí
| Název práce v češtině: | Vliv parazita Toxoplasma gondii na produkci hlavních močových proteinů u myši domácí |
|---|---|
| Název v anglickém jazyce: | The role of Toxoplasma gondii on the expression of Major Urinary Proteins in the house mouse |
| Klíčová slova: | hlavní močové proteiny, MUP, Toxoplasma gondii, paraziti, infekce, feromon, pachová signalizace |
| Klíčová slova anglicky: | Major Urinary Proteins, MUP, Toxoplasma gondii, parasites, infection, pheromone, odor, scent marking |
| Akademický rok vypsání: | 2008/2009 |
| Typ práce: | diplomová práce |
| Jazyk práce: | čeština |
| Ústav: | Katedra parazitologie (31-161) |
| Vedoucí / školitel: | prof. Mgr. Pavel Stopka, Ph.D. |
| Řešitel: | skrytý - zadáno a potvrzeno stud. odd. |
| Datum přihlášení: | 24.11.2008 |
| Datum zadání: | 12.07.2010 |
| Datum odevzdání elektronické podoby: | 28.08.2010 |
| Datum proběhlé obhajoby: | 10.09.2010 |
| Oponenti: | doc. RNDr. Ivan Hrdý, Ph.D. |
| Předběžná náplň práce |
| Most of biological processes involve globular transporters belonging to a lipocalin protein family. Their physiological role depends on the level of expression in particular tissue and types of substances that these proteins transport in their eight-stranded beta barrel. Among various lipocalins, Major Urinary Proteins (MUP) and Odorant Binding Proteins (OBP) are well known for their capacity to bind and carry odorants / pheromones and have been studied to detail in various mammalian models including mice, rats, and hamsters. However, many lipocalins (also including MUPs) have previously been described with respect to their protective role in an organism where they transport potentially harmful molecules to a degradation site (e.g. lysozomes) or straight out of the body. As most of lipocalins share similar secondary and tertiary structure, their potential role in both above given processes may be additive (mixed). The aim the thesis is to determine the relationship between the presence of selected infections and production of selected lipocalins in mice. |
| Předběžná náplň práce v anglickém jazyce |
| Most of biological processes involve globular transporters belonging to a lipocalin protein family. Their physiological role depends on the level of expression in particular tissue and types of substances that these proteins transport in their eight-stranded beta barrel. Among various lipocalins, Major Urinary Proteins (MUP) and Odorant Binding Proteins (OBP) are well known for their capacity to bind and carry odorants / pheromones and have been studied to detail in various mammalian models including mice, rats, and hamsters. However, many lipocalins (also including MUPs) have previously been described with respect to their protective role in an organism where they transport potentially harmful molecules to a degradation site (e.g. lysozomes) or straight out of the body. As most of lipocalins share similar secondary and tertiary structure, their potential role in both above given processes may be additive (mixed). The aim the thesis is to determine the relationship between the presence of selected infections and production of selected lipocalins in mice. |