Plant exocyst subunits EXO70 in autophagy and secretion
Název práce v češtině: | Podjednotky EXO70 rostlinného komplexu exocyst v autufagii a sekreci |
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Název v anglickém jazyce: | Plant exocyst subunits EXO70 in autophagy and secretion |
Klíčová slova: | exocyst; sekrece; autofagie; nekonvenční sekrece bílkovin; Arabidopsis; transport a ukládání kovů u rostlin |
Klíčová slova anglicky: | exocyst; secretion; autophagy; unconventional protein secretion; Arabidopsis; metal transport and deposition in plants |
Akademický rok vypsání: | 2022/2023 |
Typ práce: | disertační práce |
Jazyk práce: | angličtina |
Ústav: | Katedra experimentální biologie rostlin (31-130) |
Vedoucí / školitel: | prof. RNDr. Viktor Žárský, CSc. |
Řešitel: | skrytý - zadáno vedoucím/školitelem |
Datum přihlášení: | 12.10.2022 |
Datum zadání: | 12.10.2022 |
Konzultanti: | prof. RNDr. Fatima Cvrčková, Dr. |
RNDr. Michal Hála, Ph.D. | |
Zásady pro vypracování |
Plant cell biology ; Plant developmental biology; Plant Physiology (as an alternative) |
Seznam odborné literatury |
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Předběžná náplň práce |
Před 10 lety byla popsána údajná nová organela v rostlinných buňkách - EXPO. Na její tvorbě se podílí také isoforma podjednotky exocystu EXO70E2. Cílem této disertace je prověřit mechanismy působení EXO70E2 a jejich možný vztah k autofagii. |
Předběžná náplň práce v anglickém jazyce |
Ten years ago, a plant-specific endomembrane compartment – the EXPO (Exocyst-Positive Organelle) was described. Markers for the Golgi, early or late endosome do not colocalize with double membrane EXPO; it is not induced by starvation, does not co-localize with autophagosomes and does not fuse with the vacuole. Instead, it fuses with the plasma membrane, releasing a single membrane vesicle into the cell wall, comprising a putative new EXPO exocytotic pathway. Further studies of this pathway focused on EXO70E2 subunit of the Arabidopsis exocyst complex. However, over the years we found that original EXPO features are mostly related to artefacts connected with exocyst subunits overexpression, and - most importantly - for the EXO70B1 isoform we proved unequivocally direct link to autophagy. In this project we will focus on major EXPO forming protein EXO70E2 and its closest homolog EXO70E1, test its direct connection to the autophagy pathway, address its currently unknown biological role, and clarify outstanding questions and problems of the EXPO compartment concept in plant cells. |