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Vliv diety na rozvoj jaterního poškození charakteru nealkoholické steatohepatitidy u myší
Název práce v češtině: Vliv diety na rozvoj jaterního poškození charakteru nealkoholické steatohepatitidy u myší
Název v anglickém jazyce: Effect of diet on the development of liver damage of non-alcoholic steatohepatitis in mice
Akademický rok vypsání: 2021/2022
Typ práce: diplomová práce
Jazyk práce: čeština
Ústav: Katedra biologických a lékařských věd (16-16150)
Vedoucí / školitel: PharmDr. Jana Urbánková Rathouská, Ph.D.
Řešitel: skrytý - zadáno vedoucím/školitelem
Datum přihlášení: 11.10.2021
Datum zadání: 08.12.2022
Datum a čas obhajoby: 30.05.2023 08:00
Datum odevzdání elektronické podoby:14.05.2023
Datum proběhlé obhajoby: 30.05.2023
Oponenti: RNDr. Ivana Němečková, Ph.D.
 
 
 
Zásady pro vypracování
Literární rešerše - anatomie/fyziologie jater, myší modely, NASH dieta, markery jaterního poškození
Praktická část - zpracování jaterní tkáně pro Western blot analýzu, zpracování krve pro biochemickou analýzu parametrů jaterních funkcí
Diskuse
Závěry
Seznam odborné literatury
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12. Lebeau, P. F., Byun, J. H., Platko, K., Al-Hashimi, A. A., Lhoták, Š, MacDonald, M. E., et al. (2019). Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice. JHEP Rep. 1, 418–429. doi: 10.1016/j.jhepr.2019.10.009

13. Musso, G., Gambino, R., and Cassader, M. (2013). Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid. Res. 52, 175–191. doi: 10.1016/j.plipres.2012.11.00

14. Paik, J. M., Henry, L., De Avila, L., Younossi, E., Racila, A., and Younossi, Z. M. (2019). Mortality related to nonalcoholic fatty liver disease is increasing in the United States. Hepatol. Commun. 3, 1459–1471. doi: 10.1002/hep4.1419

15. Roubtsova, A., Chamberland, A., Marcinkiewicz, J., Essalmani, R., Fazel, A., Bergeron, J. J., et al. (2015). PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. J. Lipid. Res. 56, 2133–2142. doi: 10.1194/jlr.M061952

16. Thomas, H. (2017). NAFLD: a critical role for the NLRP3 inflammasome in NASH. Nat. Rev. Gastroenterol. Hepatol. 14:197. doi: 10.1038/nrgastro.2017.21

17. Tilg, H., Effenberger, M., and Adolph, T. E. (2020). A role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)? Expert Opin. Investig. Drugs 29, 103–106. doi: 10.1080/13543784.2020.1681397

18. Tilg, H., Moschen, A. R., and Szabo, G. (2016). Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. Hepatology 64, 955–965. doi: 10.1002/ hep.28456

19. Raubenheimer P.J., Nyirenda M.J., Walker B.R. (2006) A cholinedeficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes55, 2015–2020.

20. Rinella M.E., Elias M.S., Smolak R.R., Fu T., Borensztajn J., Green R.M. (2008) Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J. Lipid Res. 49, 1068–1076.

21. Samuel V.T., Liu Z.X., Qu X. et al. (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279, 32345–323453.

22. Sha W., da Costa K.A., Fischer L.M. et al. (2010) Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J. 24, 2962–2975.

23. Tilg H. & Moschen A.R. (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52, 1836–1846.

24. Yamazaki Y., Kakizaki S., Takizawa D. et al. (2008) Interstrain differences in susceptibility to non-alcoholic steatohepatitis. J. Gastroenterol. Hepatol. 23, 276–282.
 
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