Vliv diety na rozvoj jaterního poškození charakteru nealkoholické steatohepatitidy u myší
Název práce v češtině: | Vliv diety na rozvoj jaterního poškození charakteru nealkoholické steatohepatitidy u myší |
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Název v anglickém jazyce: | Effect of diet on the development of liver damage of non-alcoholic steatohepatitis in mice |
Akademický rok vypsání: | 2021/2022 |
Typ práce: | diplomová práce |
Jazyk práce: | čeština |
Ústav: | Katedra biologických a lékařských věd (16-16150) |
Vedoucí / školitel: | PharmDr. Jana Urbánková Rathouská, Ph.D. |
Řešitel: | skrytý![]() |
Datum přihlášení: | 11.10.2021 |
Datum zadání: | 08.12.2022 |
Datum a čas obhajoby: | 30.05.2023 08:00 |
Datum odevzdání elektronické podoby: | 14.05.2023 |
Datum proběhlé obhajoby: | 30.05.2023 |
Oponenti: | RNDr. Ivana Němečková, Ph.D. |
Zásady pro vypracování |
Literární rešerše - anatomie/fyziologie jater, myší modely, NASH dieta, markery jaterního poškození Praktická část - zpracování jaterní tkáně pro Western blot analýzu, zpracování krve pro biochemickou analýzu parametrů jaterních funkcí Diskuse Závěry |
Seznam odborné literatury |
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Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid. Res. 52, 175–191. doi: 10.1016/j.plipres.2012.11.00 14. Paik, J. M., Henry, L., De Avila, L., Younossi, E., Racila, A., and Younossi, Z. M. (2019). Mortality related to nonalcoholic fatty liver disease is increasing in the United States. Hepatol. Commun. 3, 1459–1471. doi: 10.1002/hep4.1419 15. Roubtsova, A., Chamberland, A., Marcinkiewicz, J., Essalmani, R., Fazel, A., Bergeron, J. J., et al. (2015). PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. J. Lipid. Res. 56, 2133–2142. doi: 10.1194/jlr.M061952 16. Thomas, H. (2017). NAFLD: a critical role for the NLRP3 inflammasome in NASH. Nat. Rev. Gastroenterol. Hepatol. 14:197. doi: 10.1038/nrgastro.2017.21 17. Tilg, H., Effenberger, M., and Adolph, T. E. (2020). A role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)? Expert Opin. Investig. 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