Genetic and epigenetic changes in hematopoietic stem cells during chronic inflammation
| Název práce v češtině: | Genetické a epigenetické změny hematopoetických kmenových buněk způsobené chronickým zánětem |
|---|---|
| Název v anglickém jazyce: | Genetic and epigenetic changes in hematopoietic stem cells during chronic inflammation |
| Klíčová slova: | hematopoetická kmenová buňka, chronický zánět, granulocyty |
| Klíčová slova anglicky: | hematopoietic stem cell, chronic inflammation, granulocyte |
| Akademický rok vypsání: | 2020/2021 |
| Typ práce: | disertační práce |
| Jazyk práce: | angličtina |
| Ústav: | Katedra buněčné biologie (31-151) |
| Vedoucí / školitel: | Meritxell Alberich Jorda, Ph.D. |
| Řešitel: | skrytý - zadáno a potvrzeno stud. odd. |
| Datum přihlášení: | 05.10.2020 |
| Datum zadání: | 12.10.2020 |
| Datum potvrzení stud. oddělením: | 12.10.2020 |
| Seznam odborné literatury |
| 1. Liss A, Ooi CH, et al. The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors. Haematologica. 2014 Apr;99(4):697-705. 2. Zjablovskaja P, Kardosova M, et al. EVI2B is a C/EBPa target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. Cell Death Differ. 2017 Apr;24(4):705-716. 3. Wurm AA, Zjablovskaja P, et al. Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation. Nat Commun. 2017 Jun 29;8(1):46. 4. Kardosova M, Zjablovskaja P, et al. C/EBPg is dispensable for steady-state and emergency granulopoiesis. Haematologica. 2018 Aug;103(8):e331-e335. |
| Předběžná náplň práce |
| This project will determine the molecular changes in enhancers and promoters that chronic inflammation induces in hematopoietic stem cells. Next, we will investigate how these changes contribute to the development of leukemia, an hematological disorder characterized by the accumulation of malignant cells in bone marrow and blood. Together, the results of this project will uncover the mechanisms regulating hematopoietic stem cell maintenance and fate in the context of chronic inflammation, and lay the path to identify new therapeutic strategies in leukemia. The laboratory of hemato-oncology is searching for a highly motivated, enthusiastic and hard-working Ph.D student. The candidate should hold a master degree in genetics, molecular biology, cell biology, or in a related field. The candidate should be willing to work with murine models. Excellent English is required. The candidate should be a team-player and willing to work with other lab members and international collaborators. We offer a friendly and supporting environment in a state-of-the-art institution. |
| Předběžná náplň práce v anglickém jazyce |
| This project will determine the molecular changes in enhancers and promoters that chronic inflammation induces in hematopoietic stem cells. Next, we will investigate how these changes contribute to the development of leukemia, an hematological disorder characterized by the accumulation of malignant cells in bone marrow and blood. Together, the results of this project will uncover the mechanisms regulating hematopoietic stem cell maintenance and fate in the context of chronic inflammation, and lay the path to identify new therapeutic strategies in leukemia. The laboratory of hemato-oncology is searching for a highly motivated, enthusiastic and hard-working Ph.D student. The candidate should hold a master degree in genetics, molecular biology, cell biology, or in a related field. The candidate should be willing to work with murine models. Excellent English is required. The candidate should be a team-player and willing to work with other lab members and international collaborators. We offer a friendly and supporting environment in a state-of-the-art institution. |