This dissertation focuses on the advancements in the use of recombinant adeno-associated virus (rAAV) as a vector for transgenic applications. It addresses key challenges in genetic research, particularly in developing more efficient gene delivery systems and improving the production of rAAV. The research explores innovative methods for rAAV-mediated gene editing, offering strategies to enhance the creation of transgenic models. Additionally, the work introduces novel approaches for scalable rAAV production, aimed at optimizing the process for broader application in research. The results of this dissertation contribute to the growing potential of rAAV technology in genetic studies, with a focus on improving efficiency, scalability, and ethical standards in the field. This work holds significant relevance for researchers working on transgenesis, gene therapy, and model organism development.
Předběžná náplň práce v anglickém jazyce
This dissertation focuses on the advancements in the use of recombinant adeno-associated virus (rAAV) as a vector for transgenic applications. It addresses key challenges in genetic research, particularly in developing more efficient gene delivery systems and improving the production of rAAV. The research explores innovative methods for rAAV-mediated gene editing, offering strategies to enhance the creation of transgenic models. Additionally, the work introduces novel approaches for scalable rAAV production, aimed at optimizing the process for broader application in research. The results of this dissertation contribute to the growing potential of rAAV technology in genetic studies, with a focus on improving efficiency, scalability, and ethical standards in the field. This work holds significant relevance for researchers working on transgenesis, gene therapy, and model organism development.
- zadáno vedoucím/školitelem