Epigenetic regulation of histone code establishment in gametes and embryos

• Název práce v češtině: Epigenetic regulation of histone code establishment in gametes and embryos
• Název v anglickém jazyce: Epigenetic regulation of histone code establishment in gametes and embryos
• Akademický rok vypsání: 2019/2020
• Typ práce: disertační práce
• Jazyk práce: angličtina
• Ústav: Ústav histologie a embryologie (14-40)
• Vedoucí / školitel: doc. Ing. Jan Nevoral, Ph.D.
• Řešitel: skrytý - zadáno vedoucím/školitelem
• Datum přihlášení: 22.10.2019
• Datum zadání: 22.10.2019
• Konzultanti: María Iniesta-Cuerda

Předběžná náplň práce v anglickém jazyce

Histone code is essential tool in mammalian gametogenesis. The regulation of its establishment is responsible for the successful maturation of oocytes and spermatozoa, fertilization and embryonic development. There is the hypothesis that adequate changes of histone code are associated with the capability of fertilization and early embryonic development. This presumption will be elucidated based on mouse model usage, in vivo treatment with epigenetic modulators, followed by immunocytochemical analysis of gametes and embryos. The understanding of the regulation will provide possibilities for the improvement of embryonic development, including the knowledge transfer to human assisted reproduction.