Vliv daunorubicinu na aterogenezi u králíků krmených cholesterolovou dietou

• Název práce v češtině: Vliv daunorubicinu na aterogenezi u králíků krmených cholesterolovou dietou
• Název v anglickém jazyce: Daunorubicin effects on atherogenesis in rabbits fed by cholesterol diet.
• Akademický rok vypsání: 2017/2018
• Typ práce: bakalářská práce
• Jazyk práce: čeština
• Ústav: Katedra biologických a lékařských věd (16-16150)
• Vedoucí / školitel: prof. PharmDr. Petr Nachtigal, Ph.D.
• Řešitel: skrytý - zadáno vedoucím/školitelem
• Datum přihlášení: 17.10.2017
• Datum zadání: 20.02.2019
• Datum a čas obhajoby: 05.06.2019 08:00
• Datum odevzdání elektronické podoby: 13.04.2019
• Datum proběhlé obhajoby: 05.06.2019
• Oponenti: RNDr. Ivana Němečková, Ph.D.

Zásady pro vypracování

Literární rešerše
Histologická analýza velikosti aterosklerotických plátů
Kvantifikace velikosti aterosklerotických plátů.
Vyhodnocení výsledků

Seznam odborné literatury

1. Adamcova M, Pelouch V, Gersl V, Kaplanova J, Mazurova Y, Simunek T, Klimtova I, Hrdina R. Protein profiling in daunorubicin-induced cardiomyopathy. General physiology and biophysics. 2003;22:411-419
2. Adamcova M, Potacova A, Popelova O, Sterba M, Mazurova Y, Aupperle H, Gersl V. Cardiac remodeling and mmps on the model of chronic daunorubicin-induced cardiomyopathy in rabbits. Physiological research. 2010;59:831-836
3. Cernecka H, Ochodnicka-Mackovicova K, Kucerova D, Kmecova J, Nemcekova V, Doka G, Kyselovic J, Krenek P, Ochodnicky P, Klimas J. Enalaprilat increases pparbeta/delta expression, without influence on pparalpha and ppargamma, and modulate cardiac function in sub- acute model of daunorubicin-induced cardiomyopathy. European journal of pharmacology. 2013;714:472-477
4. Daley SJ, Klemp KF, Guyton JR, Rogers KA. Cholesterol-fed and casein-fed rabbit models of atherosclerosis. Part 2: Differing morphological severity of atherogenesis despite matched plasma cholesterol levels. Arteriosclerosis and thrombosis : a journal of vascular biology. 1994;14:105-141
5. Doka G, Malikova E, Galkova K, La Rocca G, Kruzliak P, Adamek M, Rodrigo L, Krenek P, Klimas J. Downregulation of myogenic micrornas in sub-chronic but not in sub-acute model of daunorubicin-induced cardiomyopathy. Molecular and cellular biochemistry. 2017;432:79-89
6. Du L, Dronadula N, Tanaka S, Dichek DA. Helper-dependent adenoviral vector achieves prolonged, stable expression of interleukin-10 in rabbit carotid arteries but does not limit early atherogenesis. Human gene therapy. 2011;22:959-968
7. Gersl V, Bajgar J, Hrdina R, Mazurova Y, Machackova J, Cerman J, Suba P. Cholinesterases in dexrazoxane-treated daunorubicin cardiomyopathy in rabbits. General physiology and biophysics. 1999;18:335-346
8. Gersl V, Cerman J, Suba P, Mazurova Y, Hrdina R, Machackova J. Igf-i in experimental daunorubicin-induced cardiomyopathy in rabbits. Human & experimental toxicology. 1999;18:154-161
9. Gersl V, Hrdina R. Noninvasive polygraphic cardiac changes in daunorubicin-induced cardiomyopathy in rabbits. Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove. 1994;37:49-55
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11. Habiyakare B, Alsaadon H, Mathai ML, Hayes A, Zulli A. Reduction of angiotensin a and alamandine vasoactivity in the rabbit model of atherogenesis: Differential effects of alamandine and ang(1-7). International journal of experimental pathology. 2014;95:290-295
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13. Kucerova D, Doka G, Kruzliak P, Turcekova K, Kmecova J, Brnoliakova Z, Kyselovic J, Kirchhefer U, Muller FU, Krenek P, Boknik P, Klimas J. Unbalanced upregulation of ryanodine receptor 2 plays a particular role in early development of daunorubicin cardiomyopathy. American journal of translational research. 2015;7:1280-1294
14. Lamb DJ, Avades TY, Ferns GA. Endogenous neutralizing antibodies against platelet-derived growth factor-aa inhibit atherogenesis in the cholesterol-fed rabbit. Arteriosclerosis, thrombosis, and vascular biology. 2001;21:997-1003
15. Meijer GW, Beems RB, Janssen GB, Vaessen HA, Speijers GJ. Cadmium and atherosclerosis in the rabbit: Reduced atherogenesis by superseding of iron? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1996;34:611-621
16. Nachtigal P, Semecky V, Kopecky M, Gojova A, Solichova D, Zdansky P, Zadak Z. Application of stereological methods for the quantification of vcam-1 and icam-1 expression in early stages of rabbit atherogenesis. Pathology, research and practice. 2004;200:219-229
17. Najafipour H, Joukar S. Combination of opium smoking and hypercholesterolemia augments susceptibility for lethal cardiac arrhythmia and atherogenesis in rabbit. Environmental toxicology and pharmacology. 2012;34:154-159
18. Perrey S, Legendre C, Matsuura A, Guffroy C, Binet J, Ohbayashi S, Tanaka T, Ortuno JC, Matsukura T, Laugel T, Padovani P, Bellamy F, Edgar AD. Preferential pharmacological inhibition of macrophage acat increases plaque formation in mouse and rabbit models of atherogenesis. Atherosclerosis. 2001;155:359-370
19. Potacova A, Adamcova M, Sterba M, Popelova O, Simunek T, Mazurova Y, Guncova I, Gersl V. A pilot study of matrix metalloproteinases on the model of daunorubicin-induced cardiomyopathy in rabbits. Acta medica. 2007;50:109-111
20. Potacova A, Adamcova M, Sterba M, Popelova O, Simunek T, Mazurova Y, Guncova I, Gersl V. A pilot study of matrix metalloproteinases on the model of daunorubicin-induced cardiomyopathy in rabbits. Acta medica. 2007;50:109-111
21. Rajs J, Isberg B, Paul C, Ahlberg NE. Daunorubicin-induced chronic cardiomyopathy--an experimental model system for study of sudden death. A preliminary report. Forensic science international. 1982;20:217-225
22. Saad SY, Najjar TA, Arafah MM. Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in rats. Basic & clinical pharmacology & toxicology. 2006;99:412-417
23. Srankova J, Doka G, Pivackova L, Mesarosova L, Kyselovic J, Klimas J, Krenek P. Daunorubicin down-regulates the expression of stem cell markers and factors involved in stem cell migration and homing in rat heart in subchronic but not acute cardiomyopathy. Basic & clinical pharmacology & toxicology. 2016;119:443-452
24. Wang BY, Niebauer J, Singer AH, Tsao PS, Cooke JP. Felodipine inhibits intimal lesion formation in the hypercholesterolemic rabbit: Differential effects on endothelial and monocyte determinants of atherogenesis. Vascular medicine. 1996;1:173-179
25. Wang BY, Singer AH, Tsao PS, Drexler H, Kosek J, Cooke JP. Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. Journal of the American College of Cardiology. 1994;23:452-458
26. Yanni AE, Agrogiannis G, Nomikos T, Fragopoulou E, Pantopoulou A, Antonopoulou S, Perrea D. Oral supplementation with l-aspartate and l-glutamate inhibits atherogenesis and fatty liver disease in cholesterol-fed rabbit. Amino acids. 2010;38:1323-1331

Předběžná náplň práce

Literární rešerše
Histologická analýza velikosti aterosklerotických plátů
Kvantifikace velikosti aterosklerotických plátů.
Vyhodnocení výsledků