The role of endometriosis in the development of dyspareunia and algopareunia.

• Název práce v češtině: Role endometriózy v rozvoji dyspareunie a algopareunie.
• Název v anglickém jazyce: The role of endometriosis in the development of dyspareunia and algopareunia.
• Klíčová slova: Endometriosa; Stres; Somatoformní disociace; CA-125; CA 19-9;DHEA-S; SDQ-20;TSC-40;Rosen
• Klíčová slova anglicky: Endometriosis; Stress; Somatoform dissociation; CA-125; CA 19-9;DHEA-S; SDQ-20;TSC-40;Rosen
• Akademický rok vypsání: 2016/2017
• Typ práce: disertační práce
• Jazyk práce: angličtina
• Ústav: Sexuologický ústav 1.LF a VFN v Praze (11-00390)
• Vedoucí / školitel: doc. MUDr. Jaroslav Zvěřina, CSc.
• Řešitel: skrytý - zadáno a potvrzeno stud. odd.
• Datum přihlášení: 03.10.2016
• Datum zadání: 03.10.2016
• Datum potvrzení stud. oddělením: 21.01.2019
• Datum a čas obhajoby: 16.04.2019 09:00
• Místo konání obhajoby: knihovna Psychiatrické kliniky 1.LF UK a VFN, Ke Karlovu 11, Praha 2
• Datum odevzdání elektronické podoby: 22.01.2019
• Datum proběhlé obhajoby: 16.04.2019
• Předmět: Obhajoba dizertační práce (B90002)
• Oponenti: prof. MUDr. Jan Vevera, Ph.D.

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Předběžná náplň práce

Disertační práce se zabývá závažným civilizačním onemocněním, kterým je endometrióza. Je složena z několika studií, které se tímto onemocněním zabývají. První část je psána ve formě review a shrnuje komplexní a aktuální informace o endometrióze z imunologického hlediska. Další část studie se zaměřuje na informace o pacientkách v rámci osobní anamnézy, jako jsou věk, začátek první menstruace, dysmenorhoe, BMI, kouření aj. Další studie zaměřená na skupinu 50 pacientek se snaží nalézt speciální marker, který by umožnil diagnostikovat endometriózu dříve, nežli se onemocnění plně rozvine. Průměrná doba od prvních příznaků po správnou diagnózu trvá obvykle přibližně 11 let. V následující studii u skupiny 55 pacientek je zkoumán pomocí Spearmanovy korelace vztah mezi traumatizací, stresem a endometriózou za pomoci speciálních dotazníků TSC-40 a SDQ-20. Poslední část studie je věnována vyhodnocení vnímání dyspareunie podle Rosenova dotazníku před konservativní léčbou, po šestiměsíční hormonální léčbě a po chirurgické léčbě.

Předběžná náplň práce v anglickém jazyce

The dissertation deals with a serious civilization disease, which is endometriosis. It is made up of several studies that deal with this disease. The first part is written as a review and summarizes the comprehensive and up-to-date informations on endometriosis from an immunological point of view. Another part of the study focuses on information on patients within a personal case history such as age, first menstrual period, dysmenorhoe, BMI, smoking, etc. Another study aimed at a group of 50 patients seeks to find a special marker to diagnose endometriosis before the disease is fully developed. The average time from the first symptoms to the correct diagnosis usually takes about 11 years.In the following study, the relationship between traumatization, stress and endometriosis was investigated using a Spearman correlation in a group of 55 patients using special TSC-40 and SDQ-20 questionnaires. The last part of the study is devoted to the evaluation of dyspareunia perception of Rosen's questionnaire before conservative treatment, after six months of hormonal treatment and after surgical treatment.