Mathematical Modeling and Simulation of Endosomal Escape Processes
| Název práce v češtině: | Mathematical Modeling and Simulation of Endosomal Escape Processes |
|---|---|
| Název v anglickém jazyce: | Mathematical Modeling and Simulation of Endosomal Escape Processes |
| Akademický rok vypsání: | 2019/2020 |
| Typ práce: | disertační práce |
| Jazyk práce: | čeština |
| Ústav: | Matematický ústav UK (32-MUUK) |
| Vedoucí / školitel: | Christoph Allolio, Ph.D. |
| Řešitel: | skrytý - zadáno a potvrzeno stud. odd. |
| Datum přihlášení: | 20.02.2020 |
| Datum zadání: | 20.02.2020 |
| Datum potvrzení stud. oddělením: | 02.03.2020 |
| Zásady pro vypracování |
| After endocytosis many bioconjugate drugs remain trapped in endosomes, consequently they cannot reach their targets in the cytosol. Cell penetrating peptides can passively enter the cell via an extensive remodeling of the cellular membrane, in a mechanism that might also be applied to endosomal escape. Membrane deformations, including fusion, can be modeled using the Helfrich-Hamm-Kozlov (HHK) theory of curvature elasticity. Recent advances allow to extract the parameters of this theory from molecular dynamics simulations. The thesis consists of the implementation of numerical solvers for variational problems in the HHK theory in order to explore different mechanisms of endsomal escape as well as molecular dynamics simulations. |
| Seznam odborné literatury |
| [1] C. Allolio, A. Magarkar, P. Jurkiewicz, K. Baxova, P. E. Mason, R. Šachl, M. Cebecauer, M. Hof, D. Horinek, V. Heinz, R. Rachel, C. Ziegler, A. Schrofel, P. Jungwirth Proc. Natl. Acad. Sci. U.S.A., 115, 11923-11928 (2018)
[2] M. Hamm and M.M. Kozlov Eur. Phys. J. E 3, 323–335 (2000) [3] A. Guckenberger, S. Gekle 2017 J. Phys.: Condens. Matter 29203001 (2017) |