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Výsledky projektu Příprava disperzních injikovatelných porézních nano-mikro systémů pro řízené uvolňování bioaktivních látek.
Výsledky
  Typ výsledku
Autor celku
Název celku(Celkem 10 zázn.)
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| Filová, E., Rampichová M., Litvinec, A., Držík, M., Míčková, A., Buzgo, M., Košťáková, E., Martinová, L., Usvald, D., Prosecká, E., Uhlík, J., Motlík, J., Vajner, L., Amler, E. A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs.. International Journal of Pharmaceutics, 2013, sv. 447(1-2), s. 139–149. ISSN 0378-5173. IF 3.458. [Článek v časopise] A novel drug delivery system was developed on the basis of the intake effect of liposomes encapsulated in PVA nanofibers. Time-controlled release of insulin and bFGF improved MSC viability in vitro. In addition, cell-free composite scaffolds containing PVA nanofibers enriched with liposomes, bFGF, and insulin were implanted into seven osteochondral defects of miniature pigs; control defects were left untreated. The cell-free composite scaffold enhanced migration of the cells into the defect, and their differentiation into chondrocytes; the scaffold was able to enhance the regeneration of osteochondral defects in minipigs. key words (3): Cartilage; Fibrin; Nanofibers |
| Buzgo, Matej, Jakubova, Radka, Mickova, Andrea, Rampichova, Michala, Prosecka, Eva, Kochova, Petra, Lukas, David, Amler, Evzen. Time-regulated drug delivery system based on coaxially incorporated platelet alpha granules for biomedical use. Nanomedicine-UK, 2012, sv. 8(7), s. 1137–1154. ISSN 1743-5889. IF 5.260. [Článek v časopise] Alpha granules are novel source of natural growth factors from platelets. In recent work we had sucesfully embedded alpha granules into nanofibers with core/shell structure. The alpha granules survived the electrospinning proces and growth factors retained their bioaktivity as was demonstarted on the model of chondrocytes and mesenchymal stem cells. key words (3): Core-shell nanofibers, alpha granules, cartilage tissue engineering |
| Amler, Evzen, Míčková, Andrea, Buzgo, Matej. Electrospun core/shell nanofibers: a promising system for cartilage and tissue engineering? . Nanomedicine-UK, 2013, sv. 8(4), s. 509–512. ISSN 1743-5889. IF 5.260. [Článek v časopise] Review article dealing with highly interesting topic of core/shell nanofibers. The authors sumarize state of field and discuss most challenging problems in their practival aplication involving regulated drug delivery, stability of delivered substances, reproducibility and productivity of the electrospinning proces and clinical aplication of nanofibers. key words (3): core-shell nanofibers, electrospinning, drug delivery |
| Buzgo, Matej, Jakubova, Radka, Mickova, Andrea, Rampichova, Michala, Prosecka, Eva, Kochova, Petra, Lukas, David, Amler, Evzen. Time-regulated drug delivery system based on coaxially incorporated platelet a-granules for biomedical use. Nanomedicine-UK, 2012, sv. ?, s. 1–18. ISSN 1743-5889. IF 5.055. [Článek v časopise] doi:10.2217/NNM.12.140 article available online Original submitted 21 March 2012; Revised submitted 8 August 2012 Posted online on 2 Dec 2012. http://www.futuremedicine.com |
| Knotek, Petr, Pouzar, Miloslav, Buzgo, Matej, Krizkova, Barbora, Vlcek, Milan, Mickova, Andrea, Plencner, Martin, Navesnik, Jakub, Amler, Evzen, Belina, Petr. Cryogenic grinding of electrospun poly-ε-caprolactone mesh submerged in liquid media. Materials Science and Engineering C- Materials for Biological Applications , 2012, sv. 32, s. 1366–1374. ISSN 0928-4931. IF 2.686. [Článek v časopise] |
| Mickova, Andrea, Buzgo, Matej, Benada, Oldřich, Rampichová, Michala, Fišar, Zdeněk, Filová, Eva, Tesařová, Martina, Lukáš, David, Amler, Evžen. Core/Shell Nanofibers with Embedded Liposomes as a Drug Delivery 2 System. Biomacromolecules, 2012, sv. 13(4), s. 952–962. ISSN 1525-7797. IF 5.479. [Článek v časopise] doi: 10.1021/bm2018118 |
| Plencner, M., East, B., Otahal, M.,Lytvynets, A., Krejci, T., Prosecka, E., Rampichova, M., Buzgo, M., Mickova, A., Hoch, J., Amler, E., Abstrakt k posteru, konference Term Stem, Porto, Portugalsko, 10. - 12.10.2013 Buzgo, M., Mickova, A., Filova, E., Rampichova, M., Prosecka, E., Amler, E. ADVANCED NANOFIBERS FOR REGULATED DRUG DELIVERY.konference Term Stem, Porto, Portugalsko, 10. - 12.10.2013 [Jiný výsledek] |
| Míčková A., Buzgo M., Vocetková K., Kodedová B., Královič M., Rampichová M., Prosecká E., Plencner M., Amler E. , Time regulated nanofiber composite drug delivery systems for biomedical use. XXXVI. Dny lékařské biofyziky, 29. - 31.5. 2013, Lázně Bělohrad, ČR. [Jiný výsledek] |
| Mickova, A., Buzgo, M., Benada, O., Rampichova, M., Fisar, Z, Filova, E., Tesarova, M., Bezdeková, D., Lukas, D., Amler, E., TERM STEM 2012, 9. 10. – 13. 10. 2012, Guimarães, Portugal Core/shell nanofibers with embedded liposomes as a drug delivery system (oral presentation). TERM STEM 2012, 9. 10. – 13. 10. 2012, Guimarães, Portugal M. Rampichová, M. Buzgo, E. Prosecká, A. Míčková, E. Filová, M. Pouzar, E. Amler (poster). Injectable hydrogel functionalized by nanofibres as a drug delivery system for skeletal tissues regeneration [Jiný výsledek] |
| Mickova, Andrea, Prednáška na konferencii Term Stem 2012, Guimaraes, Portugalsko 9-13.10.2012 [Jiný výsledek] |