velikost textu
Výsledky projektu Význam posttranslačních modifikací fosfatázy Wip1 pro regulaci dynamiky buněčné odpovědi na poškození DNA
Výsledky
  Typ výsledku
Autor celku
Název celku(Celkem 6 zázn.)
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| Benada, Jan; Macurek, Libor. Targeting the Checkpoint to Kill Cancer Cells. Biomolecules, 2015, sv. 5, s. 1912–1937. ISSN 2218-273X. [Článek v časopise] Abstract: Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, inhibiting the checkpoint kinases alone could act as a directed anti-cancer therapy. Here, we review the current status of inhibitors targeted towards the checkpoint effectors and discuss mechanisms of their actions in killing of cancer cells. |
| Benada, Jan, Rozšiřující obrazové materiály [Jiný výsledek] |
| Jaiswal, Himjyot; Benada, Jan; Müllers, Erik; Akopyan, Karen; Burdova, Kamila; Koolmeister, Tobias; Helleday, Thomas; Medema, René H; Macurek, Libor; Lindqvist, Arne , preprint: An ATM/Wip1-dependent timer controls the minimal duration of a DNA-damage mediated cell cycle arrest. [Jiný výsledek] |
| Benada, Jan, Poster: "Wip1 posttranslational modi cations in regulation of DNA damage response" [Jiný výsledek] |
| Benada, Jan, poster - "Plk1 phosphorylates 53BP1 and inhibits DNA damage response in mitosis"; viz příloha: 2014_poster02 [Jiný výsledek] |
| Benada, Jan, poster - "High-content microscopy screening to identify novel chemical compounds modulating DNA damage response"; viz příloha: 2014_poster01 [Jiný výsledek] |