Virtuální mobilita / počet míst pro virtuální mobilitu:
ne
Stav předmětu:
vyučován
Jazyk výuky:
čeština
Vysvětlení:
Students who would like to continue with their MSc. study in Immunology are expected to pass both immunology courses: MB150P14E and MB151P103E - enroll to the Moodle course, please = Elearning course (link below)
Poslední úprava: RNDr. Karel Drbal, Ph.D. (24.02.2017)
Please note: the lectures are given in English language only.
A basic, one-semestral course on immune system functioning from the systems biology point of view.
The education based on data-driven knowledge is a compatible supplement to the hypothesis-driven classical education in immunology (winter semester MB150P14E Immunology). Prospectively, our theoretical lessons will be followed by a practical course on data analysis. For the time being, we will coordinate our following topic with the previous practical lesson of the Czech course MB151P102 (Genomické metody).
There is no qualification prerequisite. We will always repeat the basics of both Immunology and -omics technologies in the first half of the lesson followed by examples of 1-2 current studies in systems immunology.
Suitable for students of biology, medicine, chemistry. The course is targeted to students of 3rd (BSc.) and 4th (1st MSc.) year and PhD students in biomedical fields, incl. medical faculty students as well as Erasmus students.
Literatura - angličtina
Poslední úprava: RNDr. Karel Drbal, Ph.D. (07.03.2019)
Compulsory reading:
Lectures on the Moodle course web site include:
primary publications,
data examples and
recommended SW to be used
Lecture attendance is essential - we will focus on interactive method using real data and will discuss the outputs
Recommended reading:
Basic immunology:
L. Sompayrac: How the Immune System Works, 4th Edition, John Wiley & Sons, 2012, 152 pages, ISBN-13 978-0470657294
Expert-level immunology:
K. Murphy: Janeway's Immunobiology (Immunobiology: The Immune System (Janeway)), 8th Edition, Garland Science Publishing 2011, 888 pages, ISBN-13: 978-0815342434
M. Roederer et al.: The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis. http://www.ncbi.nlm.nih.gov/pubmed/25772697
Požadavky ke zkoušce - angličtina
Poslední úprava: RNDr. Karel Drbal, Ph.D. (24.02.2017)
This is the first year and I plan to test your abilities and knowledge using a simple home project on a selected topic listed in the Moodle course. This shall comprise both review of primary papers,, database search and data visualization. Based on the feedback this year I would generate a multiple-choice test having the database queries an integral part of the exam.
A computer test having 10 multiple-choice questions (5 answers each) with 3 hour time limit.
Evaluation: - each question is ranked by +5 points in total, if answered correctly - there are one or more correct answers per question possible - each of 5 answers per question is ranked from -2 (incorrect) up to +5 (a single correct answer) points
Classification:
100-94 points = A (excellent - summa cum laude)
93-80 = B (very good - insigni cum laude); in Czech classification system = 1
79-60 points = C (good - magna cum laude); in Czech classification system = 2
59-47 points = D (quite good - cum laude); in Czech classification system = 3
46-40 = E (pass - rite); in Czech classification system = 3
below 39 = FX, F (fail); in Czech classification system = 4
The borderline results (- 2 points) will be retested orally immediately after the test.
Sylabus - angličtina
Poslední úprava: RNDr. Karel Drbal, Ph.D. (24.02.2017)
Syllabus: In the summer semester (Immunology - a systems biology view), each lesson starts with a brief summary and repetition of essential building blocks (30 min) and continue with the online resources for data analysis. Using 1-2 examples of recent publications we are going to demonstrate how the building blocks of immune system cooperate and the immune system functions in collaboraion with other body-wide systems (neuro, endocrine, metabolism) using a big data-driven systems biology approach. Final lessons show the networking at the level of cells (signaling, epigenetic, transcriptional, and posttranscriptional levels) and tissues (development, regulation, dynamics, and integration with other homeostatic systems). - Development of immune system building blocks (organs, cells, molecules) - Evolution of immune system (innate and adaptive) - comparative genomics - Receptor diversity generation - immunoreceptor databases and target identification - Signaling pathways and immunosuppression - pathway modeling - Transcription programs and immune cell polarization - microarrays, transcriptomics - Metabolic signatures of immune cell types - metabolomics - Heterogeneity of immune cells and/or target tissues/pathogens - cellomics - Classes of immune response (cytokines, chemokines) - dynamics modeling - Immune system-related pathologies and therapies - clinical databases - Immune system organization principles & integration with neural & endocrine systems - whole body imaging - Recapitulation & questions
Vstupní požadavky - angličtina
Poslední úprava: RNDr. Karel Drbal, Ph.D. (16.03.2019)
There is no prerequisite for this course.
However, it is beneficial to pass the basic course of Immunology (MB150P14E) during the winter semester and consider also a parallel practical course Genomické metody (MB151P102) in the summer semester (for Czech students only). Students who would like to continue with the MSc. study in Immunology are expected to pass both immunology courses: Immunology (MB150P14E) and Immunology - a systems biology view (MB151P103E).
