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Poslední úprava: doc. RNDr. Eva Kmoníčková, CSc. (16.11.2017)
Having completed an undergraduate degree in Pharmacology and the ability to successively work as clinicians, undergraduate dentists receive education in prescribing drugs safely and economically and are educated in principles of drug action. Overall knowledge of general medicine pharmacology is needed to make good decision for patient in dentistry office. The main attention is focused to mechanism of action of drug, its therapeutic effect , adverse effects, also to risk of toxicity, drug-drug interactions (prescribed often by other clinician), drug-food interactions. To understand how drug acts, the content of Pharmacology teaching is based on chapters of general pharmacology and special parts. General pharmacology covers pharmacodynamics (i.e. general principles of drug action, chemical mediators, receptors and other drug targets, dose-response relationship) and pharmacokinetics, i.e. absorption, distribution, metabolism , elimination (ADME) of drug. Special parts of pharmacology are devoted to body systems (cardiovascular etc.), strategy of treatment of diseases and groups of drugs according their mechanism of action. Indications, adverse effects, drug-drug interactions , contraindications are discussed. Also the role of medicinal plants is included. Outcomes and skills: After 2 semesters of Pharmacology lessons and seminars, graduates will have knowledge in pharmacotherapy related specifically to dentistry and general knowledge in pharmacotherapy from other medicinal disciplines. The graduates will be able to integrate key elements of pharmacology to make pharmacotherapy effective, safe and economic. They will be able to provide safe and legal prescription. For actual information, they know and use drug databases. They follow regulatory authorities (EMA, FDA, SÚKL). They are able to recognize and report unexpected adverse effects. They should be opened for lifelong learning. They implement new approaches in clinical practice together with personal evaluation cost/benefit of pharmacotherapeutics. |
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Poslední úprava: PharmDr. Bc. Eva Dědečková (24.02.2023)
Compulsory: Dowd Frank j. et al.: PPHARMACOLOGY AND THERAPEUTICS FOR DENTISTRY, 7th Ed., Mosby, 2016 DENTAL DRUG REFERENCE (with clinical implications) 2nd Ed., F.A. Pickett, G.T. Térézhalmy (Lippincot Williams and Wilkins), Publisher: LWW, 2009
Recommended: Neal M.J.: MEDICAL PHARMACOLOGY AT A GLANCE, 8th Ed., John Wiley & Sons, 2016 Whalen K at al.: LIPPINCOTT ILLUSTRATED REVIEWS: PHARMACOLOGY, 6th Ed., Wolters Kluwer Rang H. P.: RANG & DALE´s PHARMACOLOGY, 8th Ed., Elsevier health Sciences, 2016 |
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Poslední úprava: PharmDr. Bc. Eva Dědečková (24.02.2023)
Winter Semester Pharmacology - EA0906100
Credit requirements: Attendance at seminars, oral presentation covering latest news in pharmacy and therapeutics, submission of computer simulated experiments report and passing a credit test (covering the materials from the seminars) are compulsory. There is one regular date and two resit dates for the credit test. Credit in SIS and signed credit in Credit Book is needed.
Summer Semester Pharmacology - EA0906100
Credit requirements: Attendance at seminars, oral presentation covering latest news in pharmacy and therapeutics, submission of computer simulated experiments report and passing a credit test (covering the materials from the seminars) are compulsory. There is one regular date and two resit dates for the credit test. Credit in SIS and signed credit in Credit Book is needed.
Exam requirements: Credit in SIS and signed credit in Credit Book is needed.
G E N E R A L P H A R M A C O L O G Y Names of drugs, Definition of drug (various meaning)
Drug origin
Pharmacokinetics, Pharmacodynamics
New drugs -clinical trials, Placebo, Double blind experiments
Pharmacokinetic parameters and processes
CL, Vd, KE, T1/2, AUC, Bioavailability
Ways of administration of drugs, Single and repeated administration
Permeation of biological membranes by drugs
Absorption of drugs
Distribution and redistribution , Blood proteins and drugs, barriers
Ways of the excretion of drugs, Renal excretion
Enterohepatic circulation
Biotransformation of drugs, Phases, Reactions, CYP 450;
Induction and inhibition of enzymes, Pharmacogenetic, First pass effect
Effects of drugs, Specific, non specific effects, Drug target sites, Agonists and antagonists, Type of antagonism. Synergism (additive, potentiation) Dose x effect (graded-quantal)
Tolerance, resistence, drug dependence -characteristics
Adverse effects and reactions, Hypersensitivity and idiosyncrasy, Types of allergy
Adverse effects of drugs in mouth, Drugs and teeth
Drugs interaction (with drugs, food and diseases), Contraindications of drugs
Drugs in children, drugs in pregnancy, drugs in elderly, drugs and breast feeding
Compliance (Adherence) Emergency drugs in dental office
S P E C I A L P H A R M A C O L O G Y Peripheral and central nervous system - Transmitters, Agonists and Antagonists
Autonomic nervous system, Parasympathetic, Sympathetic, Cholinergic transmission, Parasympatomimetics, Parasympatolytics
Cholinesterases, Anticholinesterases, Reactivators of cholinesterases
Neuromuscular blocking agents, Drugs against spasm and spasticity
Adrenergic transmission, Sympathomimetics, Sympatholytics
Analgesics, Antipyretics, NSAIDs, DMARDs, Orofacial pain, Neuropathic pain,
Trigeminal pain
Histamine, Antihistamines, Immunomodulators
General anaesthetics, General anaesthesia, Perioperative drugs, Local anaesthetics
Anxiolytics and Hypnoticis in dentistry, Antiemetics
Antiepileptics and Antiparkinsonics and dentistry
CNS stimulants, Drug dependence, Antidepressants, Antipsychotic drugs
Cardiovascular pharmacotherapy and dentistry
Vitamin K, Anticoagulants, Antiagregants
Fibrinolysis, Antifibrinolytics, Control of coagulation, Drugs influencing the haemopoiesis
Gastrointestinal tract disorders and their pharmacotherapy
Hormonal therapy (overview) and substitution Glucocorticosteroids, use in stomatology
Anticancer drugs (overview)
Antibiotics and Antibacterial drugs in stomatology
Antifungal drugs in stomatology
Drugs acting on oropharynx (local treatment)
Dry mouth treatment
Natural Antioxidants
Vitamins, Minerals relevant to stomatology (A, B, C, D, E, K and Ca, F, Se)
Mercury, Chronic intoxication, Antidotes
Drugs in emergency, recommendation for Dentistry office
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Poslední úprava: PharmDr. Bc. Eva Dědečková (27.09.2021)
PHARMACOLOGY |